Just as Darwin’s finches evolved in response to natural selection in order to endure, the cells that make up a cancerous tumor similarly counter selective pressures in order to survive, evolve, and spread. Tumors are, in fact, complex sets of cells with their own unique structure and ability to change. 

Today, artificial Intelligence and machine learning tools offer an unparalleled opportunity to illuminate the generalizable rules governing tumor progression on the genetic, epigenetic, metabolic, and microenvironmental levels. 

Matthew G. Jones, an assistant professor in the MIT Department of Biology, the Koch Institute for Integrative Cancer Research, and the Institute for Medical Engineering and Science, hopes to use computational approaches to build predictive models — to play a game of chess with cancer, making sense of a tumor’s ability to evolve and resist treatment with the ultimate goal of improving patient outcomes. In this interview, he describes his current work.

Q: What aspect of tumor progression are you working to explore and characterize? 

A: A very common story with cancer is that patients will respond to a therapy at first, and then eventually that treatment will stop working. The reason this largely happens is that tumors have an incredible, and very challenging, ability to evolve: the ability to change their genetic makeup, protein signaling composition, and cellular dynamics. The tumor as a system also evolves at a structural level. Oftentimes, the reason why a patient succumbs to a tumor is because either the tumor has evolved to a state we can no longer control, or it evolves in an unpredictable manner. 

In many ways, cancers can be thought of as, on the one hand, incredibly dysregulated and disorganized, and on the other hand, as having their own internal logic, which is constantly changing. The central thesis of my lab is that tumors follow stereotypical patterns in space and time, and we’re hoping to use computation and experimental technology to decode the molecular processes underlying these transformations.  

We’re focused on one specific way tumors are evolving through a form of DNA amplification called extrachromosomal DNA. Excised from the chromosome, these ecDNAs are circularized and exist as their own separate pool of DNA particles in the nucleus. 

Initially discovered in the 1960s, ecDNA were thought to be a rare event in cancer. However, as researchers began applying next-generation sequencing to large patient cohorts in the 2010s, it seemed like not only were these ecDNA amplifications conferring the ability of tumors to adapt to stresses, and therapies, faster, but that they were far more prevalent than initially thought.

We now know these ecDNA amplifications are apparent in about 25 percent of cancers, in the most aggressive cancers: brain, lung, and ovarian cancers. We have found that, for a variety of reasons, ecDNA amplifications are able to change the rule book by which tumors evolve in ways that allow them to accelerate to a more aggressive disease in very surprising ways. 

Q: How are you using machine learning and artificial intelligence to study ecDNA amplifications and tumor evolution? 

A: There’s a mandate to translate what I’m doing in the lab to improve patients’ lives. I want to start with patient data to discover how various evolutionary pressures are driving disease and the mutations we observe. 

One of the tools we use to study tumor evolution is single-cell lineage tracing technologies. Broadly, they allow us to study the lineages of individual cells. When we sample a particular cell, not only do we know what that cell looks like, but we can (ideally) pinpoint exactly when aggressive mutations appeared in the tumor’s history. That evolutionary history gives us a way of studying these dynamic processes that we otherwise wouldn’t be able to observe in real time, and helps us make sense of how we might be able to intercept that evolution. 

I hope we’re going to get better at stratifying patients who will respond to certain drugs, to anticipate and overcome drug resistance, and to identify new therapeutic targets.

Q: What excited you about joining the MIT community?

A: One of the things that I was really attracted to was the integration of excellence in both engineering and biological sciences. At the Koch Institute, every floor is structured to promote this interface between engineers and basic scientists, and beyond campus, we can connect with all the biomedical research enterprises in the greater Boston area. 

Another thing that drew me to MIT was the fact that it places such a strong emphasis on education, training, and investing in student success. I’m a personal believer that what distinguishes academic research from industry research is that academic research is fundamentally a service job, in that we are training the next generation of scientists. 

It was always a mission of mine to bring excellence to both computational and experimental technology disciplines. The types of trainees I’m hoping to recruit are those who are eager to collaborate and solve big problems that require both disciplines. The KI [Koch Institute] is uniquely set up for this type of hybrid lab: my dry lab is right next to my wet lab, and it’s a source of collaboration and connection, and that reflects the KI’s general vision. 

The rapidly escalating conflict between Anthropic and the Pentagon, which started when the company refused to let the government use its technology to spy on Americans, has now gone to court. The Department of Defense retaliated by designating the company a “supply chain risk” (SCR). Now, Anthropic is asking courts to block the designation, arguing that the First Amendment does not permit the government to coerce a private actor to rewrite its code to serve government ends.

We agree.

As EFF, the Foundation for Individual Rights and Expression, and multiple other public interest organizations explained in a brief filed in support of Anthropic’s motion, the development and operation of large language models involve multiple expressive choices protected by the First Amendment. Requiring a company to rewrite its code to remove guardrails means compelling different expression, a clear constitutional violation. Further, the public record shows that the SCR designation is intended to punish the company both for pushing back and for its CEO’s public statements explaining that AI may supercharge surveillance practices that current law has proven ill-equipped to address.

As we also explain, the company’s concerns about how the government will use its technology are well-founded. The U.S. government has a long history of illegally surveilling its citizens without adequate judicial oversight based on questionable interpretations of its Constitutional and statutory obligations. The Department of Defense acquires vast troves of personal information from commercial entities, including individuals’ physical location, social media, and web browsing data. Other government agencies continue to collect and query vast quantities of Americans’ information, including by acquiring information from third party data brokers.

A growing body of social science research illustrates the chilling effects of these pervasive activities. Fearing retribution for unpopular views, dissenters stay silent. And AI only exacerbates the problem. AI can quickly analyze the government’s massive datasets or combine that information with data scraped off the internet, purchased through the commercial data broker market, or from local police surveillance devices and use all of that data to construct a comprehensive picture of a person’s life and infer sensitive details like their religious beliefs, medical conditions, political opinions, or even sex partners. For example, an agency could use AI to infer an individual’s association with a particular mosque based on data showing that they visited its website, followed its social media accounts, and were located near the mosque during religious services. AI can also deanonymize online speech by using public information to unmask anonymous users.

It is easy to conceive how an agency, a government employee with improper intent, or a malicious hacker could exploit these capabilities to monitor public discourse, preemptively squelch dissent, or persecute people from marginalized communities. Against this background and absent meaningful changes to the governing national security laws and judicial oversight structure, it is entirely reasonable for Anthropic—or any other company—to insist on its own guardrails.

Without action from Congress, the task of protecting your privacy has fallen in large part to Big Tech—something no one wants, including Big Tech. But if Congress won’t do it, companies like Anthropic must be allowed to step in, without facing retribution.

Joseph Paradiso thinks that the most engaging research questions usually span disciplines. 

Paradiso was trained as a physicist and completed his PhD in experimental high-energy physics at MIT in 1981. His father was a photographer and filmmaker working at MIT, MIT Lincoln Laboratory, and the MITRE Corporation, so he grew up in a house where artists, scientists, and engineers regularly gathered and interesting music was always playing. 

That mix of influences led him to the MIT Media Lab, where he is the Alexander W. Dreyfoos Professor, academic head of the Program in Media Arts and Sciences, and director of the Responsive Environments research group.

At the Media Lab, Paradiso conducts research that engages sensing of different kinds and applies it across diverse and often extreme applications. He works on developing technologies that can efficiently capture and process multiple sensing modalities, and leverages this capability in application domains like the internet of things, medicine, environmental sensing, space exploration, and artistic expression. These efforts use that information to help people better understand the world, express themselves, and connect with one another.

Early in his career, Paradiso helped pioneer the field of wireless wearable sensing. He built many systems with multiple embedded sensors that could send information from the human body in real-time. One of his early flagship projects in this area was a pair of shoes fielded in 1997 for real-time augmented dance performance that embedded 16 sensors in each shoe, allowing wearers’ movements to directly generate music through algorithmic mapping. And Paradiso’s research at the Media Lab has consistently focused on sensing and using that information in new ways. 

“When I would list all the sensors … people would laugh. But now, my watch is measuring most of these things,” Paradiso notes. “The world has moved.” 

That progression from early prototypes to everyday technology helped lay the groundwork for devices people now use regularly to track activity, health, and performance.

As sensing systems improved, Paradiso expanded his work from individuals to groups. He developed platforms that allowed dance ensembles to create music together through their collective motion. Achieving this required Paradiso and his team to develop new ways for compact wearable devices to communicate wirelessly at high speed, as well as new approaches to real-time data processing and extending the range of available microelectromechanical systems (MEMS) sensors.

Those same sensing platforms were later adapted for sports medicine in 2006. Working with doctors who support elite athletes, his array of compact, wearable sensors captured large amounts of high-speed motion data from multiple points on the body, aimed at helping clinicians assess injury risk, performance, and recovery on the go, without the complex equipment typically associated with biomechanical monitoring and clinical settings.

More recently, Paradiso’s research has extended beyond humans. Through collaborations with National Geographic Explorers, his team has deployed sensors in remote environments to study animal behavior, including low-power compact wearable devices to detect the environmental conditions around the animal as well as track them (currently on lions and hyenas in Botswana and goats in Chile), and acoustic sensors with onboard AI to detect and monitor populations of endangered honeybees in Patagonia. This work provides new ways to understand how ecosystems function and how the planet is changing.

Paradiso was named an IEEE Fellow in January, recognizing his achievement in wireless wearable sensing and mobile energy harvesting. This is the highest grade of membership in IEEE, the world’s leading professional association dedicated to advancing technology for the benefit of humanity.

Across art, health, and the natural world, Paradiso’s work reflects how foundational research at MIT can seed technologies that ripple outward over time, shaping new applications and opening new fields. As advances in wearable technologies drive the rush toward the ever-more-connected human, a persistent existential question lurks. 

“Where do I stop, versus others begin?” Paradiso asks. 

For him, the aim is not novelty for its own sake, but amplification: using technology to help people become more perceptive, better connected, and more aware of their place in a larger system.

Each year, faculty and researchers across the MIT School of Engineering are recognized with prestigious awards for their contributions to research, technology, society, and education. To celebrate these achievements, the school periodically highlights select honors received by members of its departments, institutes, labs, and centers. The following individuals were recognized in fall 2025:

Hal Abelson, the Class of 1922 Professor in the Department of Electrical Engineering and Computer Science, received the 2025 Lifetime Achievement Award for Excellence from Open Education Global. The award honors his foundational impact on open education, Creative Commons, and open knowledge movements.

Faez Ahmed, the Henry L. Doherty Career Development Professor in Ocean Utilization in the Department of Mechanical Engineering, received an Amazon Research Award for his project “AutoDA‑Sim: A Multi‑Agent Framework for Safe, Aesthetic, and Aerodynamic Vehicle Design.” Amazon Research Awards provide unrestricted funds and AWS Promotional Credits to academic researchers investigating various research topics in multiple disciplines.

Pulkit Agrawal, an associate professor in the Department of Electrical Engineering and Computer Science, received the 2025 IROS Toshio Fukuda Young Professional Award for contributions to robot learning, policy learning, agile locomotion, and dexterous manipulation. The award recognizes outstanding contributions of an individual of the IROS community who has pioneered activities in robotics and intelligent systems.

Ahmad Bahai, a professor of the practice in the Department of Electrical Engineering and Computer Science, was elected to the 2025 class of Fellows of the National Academy of Inventors for contribution to innovation in new semiconductor devices with extensive applications in clinical grade personal sensors for a variety of biomarkers. The honor recognizes inventors whose patented work has made a meaningful global impact.

Yufeng (Kevin) Chen, an associate professor in the Department of Electrical Engineering and Computer Science, received the 2025 IROS Toshio Fukuda Young Professional Award for contributions to insect‑scale multimodal robots and soft‑actuated aerial systems. The award recognizes outstanding contributions of an individual of the IROS community who has pioneered activities in robotics and intelligent systems.

Angela Koehler, the Charles W. and Jennifer C. Johnson Professor in the Department of Biological Engineering, received the 2025 Sato Memorial International Award from the Pharmaceutical Society of Japan, recognizing advancements in pharmaceutical sciences and U.S.–Japan scientific collaboration.

Dina Katabi, the Thuan (1990) and Nicole Pham Professor in the Department of Electrical Engineering and Computer Science, was elected to the National Academy of Medicine for pioneering digital health technology that enables noninvasive, off-body remote health monitoring via AI and wireless signals, and for developing digital biomarkers for Parkinson’s progression and detection. Election to the academy is considered one of the highest honors in the fields of health and medicine, and recognizes individuals who have demonstrated outstanding professional achievement and commitment to service.

Darcy McRose, the Thomas D. and Virginia W. Cabot Career Development Professor in the Department of Civil and Environmental Engineering, was selected as a 2025 Packard Fellow for Science and Engineering. The Packard Foundation established the Packard Fellowships for Science and Engineering to allow the nation’s most promising early-career scientists and engineers flexible funding to take risks and explore new frontiers in their fields of study.

Muriel Médard, the NEC Professor of Software Science and Engineering in the Department of Electrical Engineering and Computer Science, received the 2026 IEEE Richard W. Hamming Medal for contributions to coding for reliable communications and networking. Recognized for breakthroughs in network coding and information theory, Médard’s innovations improve the reliability of data transmission in applications such as streaming video, wireless networks, and satellite communications. The award is given for exceptional contributions to information sciences, systems and technology.

Tess Smidt, an associate professor in the Department of Electrical Engineering and Computer Science, was selected as a 2025 AI2050 Fellow by Schmidt Sciences for her project, “Hierarchical Representations of Complex Physical Systems with Euclidean Neural Networks.” The program supports research that aims to help AI benefit humanity by mid‑century.

The lawyers who successfully won the law’s climate authority once thought of it as a placeholder for stronger legislation.

The ruling formally rejects a policy that President Donald Trump had put on hold amid concerns that stricter efficiency standards would increase housing costs.

A startup is selling the military mobile manufacturing units that produce fuel from carbon dioxide.

Despite an executive order to take control of wildfire rebuilding, the administration implemented only one minor regulation. Improved cooperation with local officials made further moves unnecessary, administration officials said.

Lawmakers rejected a precedent-setting bill to hold fossil fuel companies liable for some insurance costs after American Petroleum Institute opposition.

New legislation is part of Democrats deploying the Congressional Review Act against Trump administration rollbacks.

The administrator appointed industry representatives and a member of a group that disputes mainstream climate science.

The court wants to know whether and how Republicans' repeal of the Greenhouse Gas Reduction Fund affects the grants fight.

The carmaker is seeking new battery revenue streams as China’s dominant suppliers cut their prices and electric vehicle growth rates slow.

New York-based Jefferies is telling clients not to panic and to stick with the clean energy sector.

Renewables and a circular economy are part of the EU’s strategic autonomy, argues new ENVI Committee Chair Pierfrancesco Maran.

The Matrix, a 5-ton electric vertical takeoff and landing vehicle, or eVTOL, is considered the largest electric aircraft built so far, at least in China.

Countries around the world are becoming increasingly concerned about their dependencies on the US. If you’ve purchase US-made F-35 fighter jets, you are dependent on the US for software maintenance.

The Dutch Defense Secretary recently said that he could jailbreak the planes to accept third-party software.

This year in a rural school district in southeastern Montana, one high school student is taking calculus. For many people, calculus is daunting enough, even when teachers are used to offering it and peers are around to help. Studying it solo can be even harder. Yet this lone student has an unusual source of support: weekly tutoring directly from an MIT undergraduate, by Zoom, a long-distance but helpful way to stay on track.

It's part of a new program called the MIT4America Calculus Project, launched from the Institute last summer, in which MIT undergraduates and alumni work with school districts across the U.S., from Montana to Texas to New York, to tutor high school students. The logic is compelling: Students are highly proficient at calculus at MIT, where it is almost a requirement for admissions and success. The new civic-minded outreach program lets those MIT people share their knowledge and skills, getting high schoolers ready for further studies and even jobs, especially in STEM fields. 

“Calculus is a gateway for many students into STEM higher education and careers,” says MIT Professor Eric Klopfer, a co-director of the MIT4America Calculus Project. “We can help more students, in more places, fulfill requirements and get into great universities across the country, whether MIT or others, and then into STEM careers. We want to make sure they have the skills to do that.”

At this point, the project is working closely with 14 school districts across the U.S., deploying 30 current MIT undergraduates and seven alumni as tutors. The weekly sessions are carefully coordinated with school administrators and teachers, and the MIT tutors have all received training. The program started with an in-person summer calculus camp in 2025; by next summer, the goal is to be collaborating with about 20 schools districts.

“We want it to have a lasting impact,” says Claudia Urrea, an education scholar and co-director of the MIT4America Calculus Project “It’s not just about students passing an exam, but having tutors who look like what the students want to be in the future, who are mentors, have conversations, and make sure the high school students are learning.” 

Klopfer and Urrea bring substantial experience to the project. Klopfer is a professor and director of the Scheller Teacher Education Program and the Education Arcade at MIT; Urrea is executive director for the PreK-12 Initiative at MIT Open Learning.

The MIT4America Calculus Project is supported through a gift from the Siegel Family Endowment and was developed as a project in consultation with David Siegel SM ’86, PhD ’91, a computer scientist and entrepreneur who is chairman of the firm Two Sigma.

“David Siegel came to us with two powerful questions: How can we spread the educational impact of MIT beyond our walls? And how can we open doors to STEM careers for U.S. high school students who don’t have access to calculus?” says MIT President Sally Kornbluth.

She adds: “The MIT4America Calculus Project answers those questions in a perfectly MIT way: Reflecting the Institute’s longstanding commitment to national service, the MIT4America Calculus Project supplies an innovative answer to a hard practical problem, and it taps the uncommon skill of the people of MIT to create opportunity for others. We’re enormously grateful to David for his inspiration and guidance, and to the Siegel Family Endowment for the financial support that brought this idea to life.”

The U.S. has more than 13,000 school districts, and about half of them offer calculus classes. The MIT effort aims to work with districts that already have existing programs but are striving to add educational support for them, often while facing funding constraints or other limitations.

In contrast to the one-student calculus situation in Montana, the project is also working with a 5,000-student district in Texas, south of Dallas, where about 60 high school students take calculus; currently five Institute undergraduates are tutoring 15 students from the district’s schools.

“Other organizations are involved in efforts like this, but I think MIT brings some unique things to it,” Klopfer says. “I think involving our undergraduates in this is an awesome contribution. Our students really do come from all over the place, and are sometimes connecting back to their home states and communities, and that makes a difference on both sides.”

He adds: “I see benefits for our students, too. They develop good ways of communicating, working with other people and building skills. They can gain a lot of great experience.”

In addition to the in-person summer calculus camp, which is expected to continue, and the weekly video tutoring, the MIT4America Calculus Project is working on developing online tools that help guide high school students as well. Still, Urrea emphasizes, the project is built around “the importance of people. A community of support is very important, to have connections that build over time.  The human aspect of the program is irreplaceable.”

The MIT tutors must pass rigorous training sessions that cover pedagogy and other aspects of working with high school students, and know they are making a substantial commitment of time and effort.

It has been worth it, as teachers say their high school students have been responding very well to the MIT tutors.

“For students to be able to see themselves in their tutors is a really cool thing,” says Shilpa Agrawal ’15, director of computer science and an AP calculus AB teacher at Comp Sci High in the Bronx, New York, where 15 students are participating in the project.

“It’s led to a lot of success for my students,” adds Agrawal, who majored in computer science at MIT. She is part of the national network of MIT-connected teachers who have been helping the program grow organically, having reached out to Jenny Gardony, manager of the MIT4America Calculus Project.

Gardony, who is also the math project manager in MIT’s Scheller Teacher Education program, has been receiving enthusiastic emails from teachers in other participating districts since the project started.

“I have to start by saying thank you,” one teacher wrote to Gardony, adding that one student “was so excited in class today. The session she had with you made her so confident. She’s always nervous, but today she was smiling and helping others, and that was 100 percent because of you.”

Gardony adds: “The fact that a busy teacher takes the time to send that email, I’m touched they would do that.” 

Nature Climate Change, Published online: 10 March 2026; doi:10.1038/s41558-026-02592-2

Changing bird nutrient inputs

Nature Climate Change, Published online: 10 March 2026; doi:10.1038/s41558-026-02593-1

Amplified variability