The following is a joint announcement from the MIT School of Architecture and Planning, MIT Schwarzman College of Computing, Hasso Plattner Institute, and Hasso Plattner Foundation.

The MIT Morningside Academy for Design (MAD), MIT Schwarzman College of Computing, Hasso Plattner Institute (HPI), and Hasso Plattner Foundation celebrated the launch of the MIT and HPI AI and Creativity Hub (MHACH) at a signing ceremony this week. This 10-year initiative aims to deepen ties between computing and design as advances in artificial intelligence are reshaping how ideas are conceived and shared.

Funded by the Hasso Plattner Foundation, MIT and HPI will work together to foster collaborative interdisciplinary research and support a portfolio of educational programs, fellowships, and faculty engagement focused on AI and creativity, expanding scholarly inquiry into AI applications across disciplines, industries, and societal challenges. The collaboration begins with an inaugural two-day workshop March 19-20 at MIT, bringing together faculty, students, and researchers to set early priorities.

“As we hear from our faculty, as the Information Age gives way to an era of imagination, we expect a new emphasis on human creativity,” reflects MIT President Sally Kornbluth. “Through this collaboration, MIT and HPI are creating a shared space where students and faculty will come together across disciplines to explore new ideas, experiment with emerging tools, and invent new frontiers at the intersection of human creativity and AI.”

“The best minds need the right environment to do their most creative work,” says Rouven Westphal, from the Hasso Plattner Foundation. “When HPI and MIT come together across disciplines and borders, they create exactly that. The Hasso Plattner Foundation is committed to supporting this collaboration for the long term, building on Hasso Plattner’s vision of uniting technological excellence with human-centered design and creativity.”

Deepening collaboration at the intersection of technology, creativity, and societal impact

Building on the success of the Hasso Plattner Institute-MIT Research Program on Designing for Sustainability, established in 2022 between MIT MAD and HPI, the new MHACH hub represents a commitment to deepen collaboration at the intersection of technology, creativity, and societal impact.

“MIT and HPI share a common commitment to turning scientific excellence into real-world impact. Through this collaboration, we will create an environment where students and researchers from both sides of the Atlantic can work together, experiment across disciplines, and learn from one another — at a time when artificial intelligence is set to profoundly shape our lives. We are convinced that this collaboration will generate ideas with impact far beyond both institutions and inspire international cooperation and innovation,” says Professor Tobias Friedrich, dean and managing director of the Hasso Plattner Institute.

“HPI and MIT exist at the nexus of technology and creativity. Expanding this dynamic relationship will generate new paths for the infusion of AI, design, and creativity, enabling students, faculty, and researchers to dream and discover novel solutions, moving more quickly than ever from idea to implementation. MAD was established to connect thinkers across and beyond the Institute, and this new era of collaboration with HPI advances that mission on a global scale,” comments Hashim Sarkis, dean of the MIT School of Architecture and Planning and the Elizabeth and James Killian (1926) Professor.

Academic leadership from MIT and HPI will jointly shape the hub’s research and teaching agenda. Based in Potsdam, Germany, HPI is a center of excellence for digital engineering advancing research, education, and societal transfer in IT systems engineering, data engineering, cybersecurity, entrepreneurship, and digital health. Through its globally recognized HPI d-school and pioneering work in design thinking methodology, HPI brings a distinctive perspective on human-centered innovation to the collaboration, alongside a strong record in AI and data science research and technology transfer.

Expanding research and education on AI and creativity

The efforts of this multifaceted initiative are intended to foster a dynamic academic community spanning MIT and HPI, anchored by Hasso Plattner–named professorships and graduate fellowships whose recipients will be actively engaged in the hub. The long-term framework is designed to provide continuity for faculty appointments, doctoral training, and cross-campus research.

The agreement also includes the development of classes and educational programs in areas of shared AI focus, along with expanded experiential opportunities through AI-focused workshops, hackathons, and summer exchanges. A steering committee composed of representatives from the MIT School of Architecture and Planning, MIT Schwarzman College of Computing, and Hasso Plattner Institute will facilitate the shared governance of MHACH.

“Creativity has always been about extending human capability. At its core, this collaboration asks what it truly means to create something new. The question isn’t whether AI diminishes creativity, but how new forms of intelligence can deepen and enrich that process. Our goal is to explore that intersection with rigor and build a cross-disciplinary scholarly and research community that shapes how AI supports the creation of new ideas and knowledge,” says Dan Huttenlocher, dean of the MIT Schwarzman College of Computing and the Henry Ellis Warren (1894) Professor of Electrical Engineering and Computer Science.

This collaboration is made possible by the Hasso Plattner Foundation’s long-term philanthropic commitment to institutions that connect technological innovation with design thinking and education. The Hasso Plattner Foundation has played a central role in establishing and supporting institutions such as the Hasso Plattner Institute and international design thinking programs that bridge disciplines and geographies.

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Growing up in the village of Kewa — located between Santa Fe and Albuquerque in New Mexico — William Pacheco, a member of the Santo Domingo Pueblo, learned the value of his language, its history, and the traditions it carries.

“We speak Keres, a language isolate found in seven villages and communities in central New Mexico,” he says. “It’s an endangered language with fewer than 10,000 speakers.” The Pueblos’ conception of ‘language,’ according to Pacheco, evokes the idea that speaking “comes from deep within.”

Pacheco is a graduate student in the MIT Indigenous Languages Initiative, a special master’s program in linguistics for members of communities whose languages are threatened. The two-year program provides its graduates with the linguistic knowledge to help them keep their communities’ languages alive. The initiative also offers expanded opportunities for students and faculty to become involved in Indigenous and endangered languages, working with both native speaker linguists in the master’s program and outside groups, ideas that appealed to him.

“There’s some complexity to our language that defies traditional instruction,” says Pacheco, who will complete his studies this spring. “I want to develop the linguistic tools I need to improve my understanding of its construction and how best to teach and preserve it.” Pacheco is keenly aware of cultural differences in how language transmission occurs. Language, he believes, evolves over time and is best learned experientially; the Western model of language learning prioritizes immediacy and test-taking.

A variety of factors complicate efforts to preserve and potentially teach Keres. Each of the villages where it’s spoken has its own distinct dialect. These dialects are mutually intelligible to various degrees based on where they’re being spoken. Additionally, the last three decades have seen a significant increase in English usage by young Pueblos, which further endangers Keres’ existence.

Furthermore, Keres isn’t a written language. For centuries, the Pueblo have relied on daily use within their homes and communities to maintain its vitality. “The community doesn’t want it written,” Pacheco says. 

Contact with the wider world has previously imperiled Indigenous ideas, an outcome Pacheco wants to avoid. “We believe [Keres] is a form of intellectual property, a tradition and artifact that is best served by empowering our people to preserve it,” he says.

From the Southwest to MIT

While he’s now passionate about linguistics, languages weren’t Pacheco’s first choice when considering an educational path. “I always admired [MIT alumnus and Nobel laureate] Richard Feynman,” he recalls. “I wanted to study physics.”

After earning an undergraduate degree from the University of New Mexico, Pacheco, who’d been working as a K-12 educator, began efforts to preserve Keres, increasing the language’s vitality and preserving its usefulness for, and value to, future generations. He sought permission and certification from the tribe to teach the language at the Santa Fe Indian School, an off-reservation boarding school. He soon discovered that a traditional Western approach to language learning wouldn’t suffice.

“Students weren’t taking the course to be scholars of the language; they wanted to learn it to build community and create opportunities to connect with elders,” Pacheco says. It was students’ advocacy, he notes, that led to the Keres learning initiative. While designing the course, however, he found gaps in his knowledge that led him to consider graduate study. 

“There are fascinating idiosyncrasies in Keres, including, for example, verb morphology — the ways in which verbs and verb sounds change,” he notes. “I wasn’t sure about how to teach them.” He sought to improve his understanding and ability by earning a master’s degree in learning design, innovation, and technology from Harvard University. While completing his studies there, he had another burst of inspiration.

“I thought a background in linguistics would prove useful,” he says. “An advisor told me about the Indigenous Languages Initiative at MIT and recommended I apply.” Pacheco knew of Professor Emeritus Noam Chomsky’s pioneering work in generative linguistics at the Institute and sought to learn more about the field’s potential to help him become a better, more effective educator and linguist. 

Upon arriving at MIT in 2024, Pacheco found himself embraced by faculty and students alike. “[MIT linguists] Adam Albright and Norvin Richards have been wonderfully supportive mentors, offering enthusiasm and expertise” he says. “I’ve benefited from MIT’s approach to linguistics and its use of scientific inquiry as a tool to explore language.” Engaging with other students working to preserve languages at risk of extinction continues to drive his work.

“MIT continually encourages us to use its resources, to collaborate, and to help one another find solutions to our unique challenges,” he says. “Networking, gathering good ideas, and having access to professors and students from a variety of disciplines is incredibly valuable.” 

MIT’s scholars, Pacheco says, are experienced with Indigenous language learning, education, and pedagogy.

Developing an organized approach to Keres research and instruction

While gratified that his work created opportunities for him to preserve and teach Keres, Pacheco marvels at his path to the Institute and its impact on his life. “It was my language, not my interest in physics, which led me to Harvard and MIT,” he says. “How did I end up at these places?”

An advantage of language and linguistics education at MIT is the rigor with which it explores language acquisition modeling and allows for alternatives to established systems. Pacheco is after new ideas for Keres language learning and education, working to develop an effective course based on generative linguistics that both preserves the Pueblos’ approach to community and offers an educational model students are likely to embrace. He’s already had opportunities to test novel theories and practices as an educator back home. 

“I was teaching students to use Keres as a programming tool,” he says. “We modeled a robot as a member of the community navigating a maze, and students would have to teach it to accept commands in Keres.” 

Pacheco also wants to explore community-centered language issues. He wants to standardize the development and education of community linguists, creating a cohort of scholars trained to use the tools he designs that are deeply invested in Keres’ preservation and instruction.

“We want to drive inquiries into Keres and how it’s taught,” he says, “while also centering Indigenous knowledge systems and expanding access to linguistics study for Indigenous scholars.”

Pacheco believes there’s value in exposing scholars and communities to the cultural and ideological exchanges he’s enjoyed between the sciences, humanities, Indigenous ideas, and experiences. “Indigenous scholars exist at MIT,” he says. “We’re here, and the Institute’s support helps preserve languages like Keres as important communal and cultural artifacts.” 

Pacheco is grateful for the opportunities his research at MIT have afforded him. While his education as a linguist and scholar continues, Pacheco’s community, culture, and support for Keres language learning remain top priorities.

“I want to amplify the impact in tribal language policy and Indigenous-centered education,” he says. “Language, its study, and its transmission is both science and art.”

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Researchers have developed a new method for monitoring iron flux — the movement and rate at which cells take in, store, use and release iron — in stem cells known as mesenchymal stromal cells (MSCs). The system can provide insights within a minute about a cell’s ability to grow cartilage tissue for cartilage repair. 

The breakthrough offers a promising pathway toward more consistent and efficient manufacturing of high‑quality MSCs for regenerative therapies to treat joint diseases such as osteoarthritis, chronic joint degeneration conditions, and cartilage injuries.

The work was led by researchers from the Critical Analytics for Manufacturing Personalized-Medicine (CAMP) group within the Singapore-MIT Alliance for Research and Technology (SMART), and was supported by the SMART Antimicrobial Resistance (AMR) research group, in collaboration with MIT and the National University of Singapore (NUS).

A paper describing the work, “Cellular iron flux measurement by micromagnetic resonance relaxometry as a critical quality attribute of mesenchymal stromal cells,” was published in February in the journal Stem Cells Translational Medicine.

Regenerative therapies hold significant promise for patients with the potential to repair damaged tissues rather than simply manage symptoms. However, one of the biggest challenges in bringing these therapies to patients lies in the unpredictable quality of the MSC’s chondrogenic potential — a cell’s ability to develop and form cartilage tissue — during the in vitro manufacturing process.

Even when grown under controlled laboratory conditions, MSCs are prone to losing some of their potential and ability to form cartilage tissue, leading to inconsistent cartilage repair outcomes due to the varying quality of MSC batches. Existing tests that evaluate the quality of MSCs’ cartilage‑forming potential are destructive in nature, which causes irreversible damage to the cells being tested and renders them unusable for further therapeutic or manufacturing purposes.

In addition, the tests require a prolonged — up to 21-day — period for cells to grow. This slows decision‑making, extends production timelines, and can hinder the timely translation of MSC-based therapies into clinical use and delay treatment for patients. As MSCs can lose chondrogenic potential during this process, early assessment is essential for manufacturers to determine whether a batch should be continued or discontinued. Hence, there is a need for a reliable and rapid method to predict MSCs’ chondrogenic potential during the cell manufacturing process.

The new developement represents a rapid, non-destructive method to monitor iron flux in MSCs by measuring iron changes in spent media — residual components in the culture medium after cell growth. Using an inexpensive benchtop micromagnetic resonance relaxometry (µMRR) device, the approach enables real‑time monitoring of cellular iron changes without damaging the cells. The inexpensive µMRR device can be easily integrated into existing laboratories and manufacturing workflows, enabling routine, real‑time quality monitoring without significant infrastructure or cost barriers.

Iron homeostasis is a critical process that maintains normal levels of iron for cell function, maintaining the balance between providing sufficient iron for essential processes, while preventing toxic accumulation. The study found that iron homeostasis is highly correlated with the MSC’s chondrogenic potential, where significant iron uptake and accumulation will reduce the cell’s ability to form cartilage. The researchers also found that supplementing the cell growth process with ascorbic acid (AA) helps regulate iron homeostasis by limiting iron flux, thereby improving the MSC’s chondrogenic potential.

Using this novel method, spent media are collected as samples and treated with AA. The µMRR device is then used to track and provide real-time insights into small iron concentration changes within the spent media. These iron concentration changes reflect how MSCs take up and release iron and can provide an early indicator of whether a batch is likely to succeed in forming good cartilage.

These findings allow manufacturers to not only monitor MSCs quality for cartilage repair in real-time, but also to assess when, and to what extent, interventions such as AA supplementation are likely to be beneficial - supporting efficient manufacturing of more effective and consistent MSC‑based therapies.

“One of the key challenges in cartilage regeneration is the inability to reliably predict whether MSCs will retain their chondrogenic potential during manufacturing. Our study addresses this by introducing a rapid, non-destructive method to monitor iron flux dynamics as a novel critical quality attribute (CQA) of MSCs' chondrogenic capacity. This approach enables early identification of suboptimal cell batches during culture, enhancing quality control efficiency, reducing manufacturing costs, and accelerating clinical translation,” says Yanmeng Yang, CAMP postdoc and first author of the paper.

“Our research sheds light on a fundamental biological process that, until now, has been extremely difficult to measure. By monitoring iron flux in real-time without destroying the cells, we can gain actionable insights into a cell batch’s chondrogenic potential, which allows for early decision-making during the manufacturing process. The findings support µMRR‑based iron monitoring as an effective quality control strategy for MSC-based therapy manufacturing, paving the way for more consistent and clinically viable regenerative medicine for cartilage regeneration,” says MIT Professor Jongyoon Han, co-head CAMP PI, AMP PI, and corresponding author of the paper.

This method represents a promising step toward improving manufacturing consistency and functional characterisation of MSC-based cellular products. Beyond advancing cell therapy manufacturing, it contributes to the scientific industry studying iron biology by providing real-time iron flux measurements that were previously unavailable. The research also advances clinical translation of high-quality cell therapies for cartilage regeneration, bringing these closer to patients with joint degeneration conditions and cartilage injuries.

Building on these findings, the researchers plan to carry out future preclinical and clinical studies to expand this approach beyond quality control in manufacturing, with the aim of establishing µMRR as a validated method for the clinical translation of MSC-based therapies in patients for cartilage repair.

The research, conducted at SMART, was supported by the National Research Foundation Singapore under its Campus for Research Excellence and Technological Enterprise (CREATE) program.

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