A ruling for a Peruvian farmer against a German energy giant would mark the first time any court has ordered a company to pay up for climate change.

Both Congressional Review Act measures cleared Congress with bipartisan support.

Democrats warned Gov. Gavin Newsom's (D) budget officials to avoid backfilling cuts with Prop 4 dollars.

Population growth, hurricanes and a vicious citrus greening disease have led to issues in the Florida orange industry.

According to projections, global warming will amp up the North Atlantic Oscillation to roughly three times larger than ever recorded by the end of the century.

In times of conflict, the internet becomes more than just a tool—it is a lifeline, connecting those caught in chaos with the outside world. It carries voices that might otherwise be silenced, bearing witness to suffering and survival. Without internet access, communities become isolated, and the flow of critical information is disrupted, making an already dire situation even worse.

At this years RightsCon conference hosted in Taiwan, Palestinian non-profit organization 7amleh, in collaboration with the Palestinian Digital Rights Coalition and supported by dozens of international organizations including EFF, launched #ReconnectGaza, a global campaign to rebuild Gaza’s telecommunications network and safeguard the right to communication as a fundamental human right. 

The campaign comes on the back of more than 17 months of internet blackouts and destruction to Gaza’s telecommunications infrastructure by  the Israeli authorities.Estimates indicate that 75% of Gaza’s telecommunications infrastructure has been damaged, with 50% completely destroyed. This loss of connectivity has crippled essential services— preventing healthcare coordination, disrupting education, and isolating Palestinians from the digital economy. In response, there is an urgent and immediate need  to deploy emergency solutions, such as eSIM cards, satellite internet access, and mobile communications hubs.

At the same time, there is an opportunity to rebuild towards a just and permanent solution with modern technologies that would enable reliable, high-speed connectivity that supports education, healthcare, and economic growth. The campaign calls for this as a paramount component to reconnecting Gaza, whilst also ensuring the safety and protection of telecommunications workers on the ground, who risk their lives to repair and maintain critical infrastructure. 

Further, beyond responding to these immediate needs, 7amleh and the #ReconnectGaza campaign demands the establishment of an independent Palestinian ICT sector, free from external control, as a cornerstone of Gaza’s reconstruction and Palestine's digital sovereignty. Palestinians have been subject to Israel internet controls since the Oslo Accords, which settled that Palestine should have its own telephone, radio, and TV networks, but handed over details to a joint technical committee. Ending the deliberate isolation of the Palestinian people is critical to protecting fundamental human rights.

This is not the first time internet shutdowns have been weaponized as a tool for oppression. In 2012, Palestinians in Gaza were subject to frequent power outages and were forced to rely on generators and insecure dial-up connections for connectivity. More recently since October 7, Palestinians in Gaza have experienced repeated internet blackouts inflicted by the Israeli authorities. Given that all of the internet cables connecting Gaza to the outside world go through Israel, the Israeli Ministry of Communications has the ability to cut off Palestinians’ access with ease. The Ministry also allocates spectrum to cell phone companies; in 2015 we wrote about an agreement that delivered 3G to Palestinians years later than the rest of the world.

Access to internet infrastructure is essential—it enables people to build and create communities, shed light on injustices, and acquire vital knowledge that might not otherwise be available. And access to it becomes even more imperative in circumstances where being able to communicate and share real-time information directly with the people you trust is instrumental to personal safety and survival. It is imperative that people’s access to the internet remains protected.

The restoration of telecommunications in Gaza is deemed an urgent humanitarian need. Global stakeholders, including UN agencies, governments, and telecommunications companies, must act swiftly to ensure the restoration and modernization of Gaza’s telecommunications.

Nature Climate Change, Published online: 17 March 2025; doi:10.1038/s41558-025-02289-y

Soil moisture droughts can have severe impacts on agriculture, which makes forecasting them crucial. Here the authors show that the dynamic predictability of these agricultural droughts decreases with climate change in many regions.

We move thanks to coordination among many skeletal muscle fibers, all twitching and pulling in sync. While some muscles align in one direction, others form intricate patterns, helping parts of the body move in multiple ways.

In recent years, scientists and engineers have looked to muscles as potential actuators for “biohybrid” robots — machines powered by soft, artificially grown muscle fibers. Such bio-bots could squirm and wiggle through spaces where traditional machines cannot. For the most part, however, researchers have only been able to fabricate artificial muscle that pulls in one direction, limiting any robot’s range of motion.

Now MIT engineers have developed a method to grow artificial muscle tissue that twitches and flexes in multiple coordinated directions. As a demonstration, they grew an artificial, muscle-powered structure that pulls both concentrically and radially, much like how the iris in the human eye acts to dilate and constrict the pupil.

The researchers fabricated the artificial iris using a new “stamping” approach they developed. First, they 3D-printed a small, handheld stamp patterned with microscopic grooves, each as small as a single cell. Then they pressed the stamp into a soft hydrogel and seeded the resulting grooves with real muscle cells. The cells grew along these grooves within the hydrogel, forming fibers. When the researchers stimulated the fibers, the muscle contracted in multiple directions, following the fibers’ orientation.

“With the iris design, we believe we have demonstrated the first skeletal muscle-powered robot that generates force in more than one direction. That was uniquely enabled by this stamp approach,” says Ritu Raman, the Eugene Bell Career Development Professor of Tissue Engineering in MIT’s Department of Mechanical Engineering.

The team says the stamp can be printed using tabletop 3D printers and fitted with different patterns of microscopic grooves. The stamp can be used to grow complex patterns of muscle — and potentially other types of biological tissues, such as neurons and heart cells — that look and act like their natural counterparts.

“We want to make tissues that replicate the architectural complexity of real tissues,” Raman says. “To do that, you really need this kind of precision in your fabrication.”

She and her colleagues published their open-access results Friday in the journal Biomaterials Science. Her MIT co-authors include first author Tamara Rossy, Laura Schwendeman, Sonika Kohli, Maheera Bawa, and Pavankumar Umashankar, along with Roi Habba, Oren Tchaicheeyan, and Ayelet Lesman of Tel Aviv University in Israel.

Training space

Raman’s lab at MIT aims to engineer biological materials that mimic the sensing, activity, and responsiveness of real tissues in the body. Broadly, her group seeks to apply these bioengineered materials in areas from medicine to machines. For instance, she is looking to fabricate artificial tissue that can restore function to people with neuromuscular injury. She is also exploring artificial muscles for use in soft robotics, such as muscle-powered swimmers that move through the water with fish-like flexibility.

Raman has previously developed what could be seen as gym platforms and workout routines for lab-grown muscle cells. She and her colleagues designed a hydrogel “mat” that encourages muscle cells to grow and fuse into fibers without peeling away. She also derived a way to “exercise” the cells by genetically engineering them to twitch in response to pulses of light. And, her group has come up with ways to direct muscle cells to grow in long, parallel lines, similar to natural, striated muscles. However, it’s been a challenge, for her group and others, to design artificial muscle tissue that moves in multiple, predictable directions.

“One of the cool things about natural muscle tissues is, they don’t just point in one direction. Take for instance, the circular musculature in our iris and around our trachea. And even within our arms and legs, muscle cells don’t point straight, but at an angle,” Raman notes. “Natural muscle has multiple orientations in the tissue, but we haven’t been able to replicate that in our engineered muscles.”

Muscle blueprint

In thinking of ways to grow multidirectional muscle tissue, the team hit on a surprisingly simple idea: stamps. Inspired in part by the classic Jell-O mold, the team looked to design a stamp, with microscopic patterns that could be imprinted into a hydrogel, similar to the muscle-training mats that the group has previously developed. The patterns of the imprinted mat could then serve as a roadmap along which muscle cells might follow and grow.

“The idea is simple. But how do you make a stamp with features as small as a single cell? And how do you stamp something that’s super soft? This gel is much softer than Jell-O, and it’s something that’s really hard to cast, because it could tear really easily,” Raman says.

The team tried variations on the stamp design and eventually landed on an approach that worked surprisingly well. The researchers fabricated a small, handheld stamp using high-precision printing facilities in MIT.nano, which enabled them to print intricate patterns of grooves, each about as wide as a single muscle cell, onto the bottom of the stamp. Before pressing the stamp into a hydrogel mat, they coated the bottom with a protein that helped the stamp imprint evenly into the gel and peel away without sticking or tearing.

As a demonstration, the researchers printed a stamp with a pattern similar to the microscopic musculature in the human iris. The iris comprises a ring of muscle surrounding the pupil. This ring of muscle is made up of an inner circle of muscle fibers arranged concentrically, following a circular pattern, and an outer circle of fibers that stretch out radially, like the rays of the sun.  Together, this complex architecture acts to constrict or dilate the pupil.

Once Raman and her colleagues pressed the iris pattern into a hydrogel mat, they coated the mat with cells that they genetically engineered to respond to light. Within a day, the cells fell into the microscopic grooves and began to fuse into fibers, following the iris-like patterns and eventually growing into a whole muscle, with an architecture and size similar to a real iris.

When the team stimulated the artificial iris with pulses of light, the muscle contracted in multiple directions, similar to the iris in the human eye. Raman notes that the team’s artificial iris is fabricated with skeletal muscle cells, which are involved in voluntary motion, whereas the muscle tissue in the real human iris is made up of smooth muscle cells, which are a type of involuntary muscle tissue. They chose to pattern skeletal muscle cells in an iris-like pattern to demonstrate the ability to fabricate complex, multidirectional muscle tissue.

“In this work, we wanted to show we can use this stamp approach to make a ‘robot’ that can do things that previous muscle-powered robots can’t do,” Raman says. “We chose to work with skeletal muscle cells. But there’s nothing stopping you from doing this with any other cell type.”

She notes that while the team used precision-printing techniques, the stamp design can also be made using conventional tabletop 3D printers. Going forward, she and her colleagues plan to apply the stamping method to other cell types, as well as explore different muscle architectures and ways to activate artificial, multidirectional muscle to do useful work.

“Instead of using rigid actuators that are typical in underwater robots, if we can use soft biological robots, we can navigate and be much more energy-efficient, while also being completely biodegradable and sustainable,” Raman says. “That’s what we hope to build toward.”

This work was supported, in part, by the U.S. Office of Naval Research, the U.S. Army Research Office, the U.S. National Science Foundation, and the U.S. National Institutes of Health.

Recognize the Worst in Government Transparency 

Co-written by MuckRock's Michael Morisy, Dillon Bergin, and Kelly Kauffman

The public's right to access government information is constantly under siege across the United States, from both sides of the political aisle. In Maryland, where Democrats hold majorities, the attorney general and state legislature are pushing a bill to allow agencies to reject public records requests that they consider "harassing." At the same time, President Donald Trump's administration has moved its most aggressive government reform effort–the Department of Government Efficiency, or DOGE–outside the reach of the Freedom of Information Act (FOIA), while also beginning the mass removal of public data sets.

One of the most powerful tools to fight back against bad governance is public ridicule. That's where we come in: Every year during Sunshine Week (March 16-22). the Electronic Frontier Foundation, MuckRock and AAN Publishers team up to publish The Foilies. This annual report—now a decade old—names and shames the most repugnant, absurd, and incompetent responses to public records requests under FOIA and state transparency laws.

Sometimes the good guys win. For example, last year we highlighted the Los Angeles Police Department for using the courts to retaliate against advocates and a journalist who had rightfully received and published official photographs of police officers. The happy ending (at least for transparency): LAPD has since lost the case, and the city paid the advocates $300,000 to cover their legal bills.

Here are this year's "winners." While they may not all pay up, at least we can make sure they get the negative publicity they're owed. 

The Exorbitant FOIA Fee of the Year: Rapides Parish School District

After a church distributed a religious tract at Lessie Moore Elementary School School in Pineville, La., young students quickly dubbed its frank discussion of mature themes as “the sex book.” Hirsh M. Joshi from the Freedom From Religion Foundation, a lawyer representing a parent, filed a request with the Rapides Parish School District to try to get some basic information: How much did the school coordinate with the church distributing the material? Did other parents complain? What was the internal reaction? Joshi was stunned when the school district responded with an initial estimate of $2 million to cover the cost of processing the request. After local media picked up the story and a bit of negotiating, the school ultimately waived the charges and responded with a mere nine pages of responsive material.

While Rapides Parish’s sky-high estimate ultimately took home the gold this year, there was fierce competition. The Massachusetts State Police wanted $176,431 just to review—and potentially not even release—materials about recruits wholeave the state’s training program early. Back in Louisiana, the Jefferson Parish District Attorney’s office insisted on charging a grieving father more than $5,000 for records on the suspicious death of his own son.

The Now You See It, Now You Don’t Award: University of Wisconsin-Madison

Sports reporter Daniel Libit’s public records request is at the heart of a lawsuit that looks a lot like the Spider-Man pointing meme. In 2023, Libit filed the request for a contract between the University of Wisconsin and Altius Sports Partners, a firm that consults college athletic programs on payment strategies for college athletes ("Name, Image, Likeness" or NIL deals), after reading a university press release about the partnership.The university denied the request, claiming that Altius was actually contracted by the University of Wisconsin Foundation, a separate 501(c)(3). So, Libit asked the foundation for the contract. The foundation then denied the request, claiming it was exempt from Wisconsin’s open records laws. After the denial, Libit filed a lawsuit for the records, which was then dismissed, because the university and foundation argued that Libit had incorrectly asked for a contract between the university and Altius, as opposed to the foundation and Altius.

The foundation did produce a copy of the contract in the lawsuit, but the game of hiding the ball makes one thing clear, as Libit wrote after: “If it requires this kind of effort to get a relatively prosaic NIL consultant contract, imagine the lengths schools are willing to go to keep the really interesting stuff hidden.”

The Fudged Up Beyond All Recognition Award: Central Intelligence Agency 

A CIA official's grandma's fudge recipe was too secret for public consumption.

There are state secrets, and there are family secrets, and sometimes they mix … like a creamy, gooey confectionary.

After Mike Pompeo finished his first year as Trump's CIA director in 2017, investigative reporter Jason Leopold sent a FOIA request asking for all of the memos Pompeo sent to staff. Seven years later, the agency finally produced the records, including a "Merry Christmas and Happy New Year" message recounting the annual holiday reception and gingerbread competition, which was won by a Game of Thrones-themed entry. ("And good use of ice cream cones!" Pompeo wrote.) At the party, Pompeo handed out cards with his mom's "secret" recipe for fudge, and for those who couldn't make it, he also sent it out as an email attachment.

But the CIA redacted the whole thing, vaguely claiming it was protected from disclosure under federal law. This isn't the first time the federal government has protected Pompeo's culinary secrets: In 2021, the State Department redacted Pompeo's pizza toppings and favorite sandwich from emails.

The You Can't Handle the Truth Award: Virginia Gov. Glenn Youngkin

In Virginia, state officials have come under fire in the past few years for shielding records from the public under the broad use of a “working papers and correspondence” FOIA exemption. When a public records request came in for internal communications on the state’s Military Survivors and Dependents Education Program, which provides tuition-free college to spouses and children of military veterans killed or disabled as a result of their service, Gov. Glenn Youngkin’s office used this “working papers” exemption to reject the FOIA request.

The twist is the request was made by Kayla Owen, a military spouse and a member of the governor’s own task force studying the program. Despite Owen’s attempts to correct the parameters of the request, Youngkin’s office made the final decision in July to withhold more thantwo folders worth of communications with officials who have been involved with policy discussions about the program.

The Courts Cloaked in Secrecy Award (Tie): Solano County Superior Court, Calif., and Washoe County District Court, Nev.

Courts are usually the last place the public can go to vindicate their rights to government records when agencies flout them. When agencies lock down records, courts usually provide the key to open them up.

Except in Vallejo, Calif., where a state trial court judge decided to lock his own courtroom during a public records lawsuit—a move that even Franz Kafka would have dismissed as too surreal and ironic. The suit filed by the American Civil Liberties Union sought a report detailing a disturbing ritual in which officers bent their badges to celebrate their on-duty killings of local residents.

When public access advocates filed an emergency motion to protest the court closure, the court denied it without even letting them in to argue their case. This was not just a bad look; it violated the California and U.S. constitutions, which guarantee public access to court proceedings and a public hearing prior to barring the courtroom doors.

Not to be outdone, a Nevada trial court judge has twice barred a local group from filming hearings concerning a public records lawsuit. The request sought records of an alleged domestic violence incident at the Reno city manager’s house. Despite the Nevada Supreme Court rebuking the judge for prohibiting cameras in her courtroom, she later denied the same group from filming another hearing. The transparency group continues to fight for camera access, but its persistence should not be necessary: The court should have let them record from the get-go.      

The No Tech Support Award: National Security Agency

NSA claimed it didn't have the obsolete tech to access lecture by military computing pioneer Grace Hopper

In 1982, Rear Adm. Grace Hopper (then a captain) presented a lecture to the National Security Agency entitled “Future Possibilities: Data, Hardware, Software, and People.” One can only imagine Hopper's disappointment if she had lived long enough to learn that in the future, the NSA would claim it was impossible for its people to access the recording of the talk.

Hopper is undoubtedly a major figure in the history of computing whose records and lectures are of undeniable historical value, and Michael Ravnitzky, frequent FOIA requester and founder of Government Attic, requested this particular lecture back in 2021. Three years later, the NSA responded to tell him that they had no responsive documents.

Befuddled, Ravnitzky pointed out the lecture had been listed in the NSA’s own Television Center Catalogue. At that point, the agency copped to the actual issue. Yes, it had the record, but it was captured on AMPEX 1-inch open reel tapes, as was more common in the 1980s. Despite being a major intelligence agency with high-tech surveillance and communication capabilities, it claimed it could not find any way to access the recording.

Let’s unpack the multi-layered egregiousness of the NSA’s actions here. It took the agency three years to respond to this FOIA. When it did, the NSA claimed that it had nothing responsive, which was a lie.  But the most colossal failure by the NSA was its claim that it couldn’t find a way to make accessible to the public important moments from our history because of technical difficulties. 

But leave it to librarians to put spies to shame: The National Archives stepped in to help, and now you can watch the lecture in two parts.

Can't get enough of The Foilies? Check out our decade in review and our archives!

Nashville’s Metropolitan Council is one vote away from passing an ordinance that’s being branded as “guardrails” against the privacy problems that come with giving the police a connected camera system like Axon’s Fusus. But Nashville locals are right to be skeptical of just how much protection from mass surveillance products they can expect.  

"I am against these guardrails," council member Ginny Welsch told the Tennessean recently. "I think they're kind of a farce. I don't think there can be any guardrail when we are giving up our privacy and putting in a surveillance system." 

Likewise, Electronic Frontier Alliance member Lucy Parsons Labs has inveighed against Fusus and the supposed guardrails as a fix to legislators’ and residents’ concerns in a letter to the Metropolitan Council. 

While the ordinance doesn’t name the company specifically, it was introduced in response to privacy concerns over the city’s possible contract for Fusus, an Axon system that facilitates access to live camera footage for police and helps funnel such feeds into real-time crime centers. In particular, local opponents are concerned about data-sharing—a critical part of Fusus—that could impede the city’s ability to uphold its values against the criminalization of some residents, like undocumented immigrants and people seeking reproductive or gender-affirming care.

This technology product, which was acquired by the police surveillance giant Axon in 2024, facilitates two major functions for police:

• With the click of a buttonx—or the tap of an icon on a map—officers can get access to live camera footage from public and private cameras, including the police’s Axon body-worn cameras, that have been integrated into the Fusus network.

• Data feeds from a variety of surveillance tools—like body-worn cameras, drones, gunshot detection, and the connected camera network—can be aggregated into a system that makes those streams quickly accessible and susceptible to further analysis by features marketed as “artificial intelligence.”

From 2022 through 2023, Metropolitan Nashville Police Department (MNPD) had, unbeknownst to the public, already been using Fusus. When the contract came back under consideration, a public outcry and unanswered questions about the system led to its suspension, and the issue was deferred multiple times before the contract renewal was voted down late last year. Nashville council members determined that the Fusus system posed too great a threat to vulnerable groups that the council has sought to protect with city policies and resolutions, including pregnant residents, immigrants, and residents seeking gender-affirming care, among others. The state has criminalized some of the populations that the city of Nashville has passed ordinances to protect. 

Unfortunately, the fight against the sprawling surveillance of Fusus continues. The city council is now making its final consideration of the aforementionedan ordinance that some of its members say will protect city residents in the event that the mayor and other Fusus fans are able to get a contract signed after all.

These so-called guardrails include:

• restricting the MNPD from accessing private cameras or installing public safety cameras in locations “where there is a reasonable expectation of privacy”; 

• prohibiting using face recognition to identify individuals in the connected camera system’s footage; 

• policies addressing authorized access to and use of the connected camera system, including how officers will be trained, and how they will be disciplined for any violations of the policy;

• quarterly audits of access to the connected camera system; 

• mandatory inclusion of a clause in procurement contracts allowing for immediate termination should violations of the ordinance be identified; 

• mandatory reporting to the mayor and the council about any violations of the ordinance, the policies, or other abuse of access to the camera network within seven days of the discovery. 

Here’s the thing: even if these limited “guardrails” are in place, the only true protection from the improper use of the AI-enabled Fusus system is to not use it at all. 

We’ve seen that when law enforcement has access to cameras, they will use them, even if there are clear regulations prohibiting those uses: 

• During protests against police brutality in San Francisco, police used live access to cameras to illegally spy on protestors.

• Black residents of a subsidized housing development became the primary surveillance targets for police officers with Fusus access in Toledo, Ohio. 

• Officers in Massachusetts have been able to use cameras with live access to conduct months-long, ongoing warrantless surveillance. 

Firms such as Fusus and its parent company Axon are pushing AI-driven features, and databases with interjurisdictional access. Surveillance technology is bending toward a future where all of our data are being captured, including our movements by street cameras (like those that would be added to Fusus), our driving patterns by ALPR, our living habits by apps, and our actions online by web trackers, and then being combined, sold, and shared.

When Nashville first started its relationship with Fusus in 2022, the company featured only a few products, primarily focused on standardizing video feeds from different camera providers. 

Now, Fusus is aggressively leaning into artificial intelligence, claiming that its “AI on the Edge” feature is built into the initial capture phase and processes as soon as video is taken. Even if the city bans use of face recognition for the connected camera system, the Fusus system boasts that it can detect humans, objects, and combine other characteristics to identify individuals, detect movements, and set notifications based on certain characteristics and behaviors. Marketing material claims that the system comes “pre-loaded with dozens of search and analysis variables and profiles that are ready for action,” including a "robust & growing AI library.” It’s unclear how these AI recognition options are generated or how they are vetted, if at all, or whether they can even be removed as would be required by the ordinance.

 

The proposed “guardrails” in Nashville are insufficient to address danger posed by mass surveillance systems, and the city of Nashville shouldn’t think they’ve protected their residents, tourists, and other visitors by passing them. Nashville residents and other advocacy groups have already raised concerns.

The only true way to protect Nashville’s residents against dragnet surveillance and overcriminalization is to block access to these invasive technologies altogether. Though this ordinance has passed its second reading, Nashville should not adopt Fusus or any other connected camera system, regardless of whether the ordinance is ultimately adopted. If Councilors care about protecting their constituents, they should hold the line against Fusus. 

A bagpipe and drum band:

SQUID transforms traditional Bagpipe and Drum Band entertainment into a multi-sensory rush of excitement, featuring high energy bagpipes, pop music influences and visually stunning percussion!

A decade after scientists in The Picower Institute for Learning and Memory at MIT first began testing whether sensory stimulation of the brain’s 40Hz “gamma” frequency rhythms could treat Alzheimer’s disease in mice, a growing evidence base supporting the idea that it can improve brain health — in humans as well as animals — has emerged from the work of labs all over the world. A new open-access review article in PLOS Biology describes the state of research so far and presents some of the fundamental and clinical questions at the forefront of the noninvasive gamma stimulation now.

“As we’ve made all our observations, many other people in the field have published results that are very consistent,” says Li-Huei Tsai, Picower professor of neuroscience at MIT, director of MIT’s Aging Brain Initiative, and senior author of the new review, with postdoc Jung Park. “People have used many different ways to induce gamma including sensory stimulation, transcranial alternating current stimulation, or transcranial magnetic stimulation, but the key is delivering stimulation at 40 hertz. They all see beneficial effects.”

A decade of discovery at MIT

Starting with a paper in Nature in 2016, a collaboration led by Tsai has produced a series of studies showing that 40Hz stimulation via light, sound, the two combined, or tactile vibration reduces hallmarks of Alzheimer’s pathology such as amyloid and tau proteins, prevents neuron death, decreases synapse loss, and sustains memory and cognition in various Alzheimer’s mouse models. The collaboration’s investigations of the underlying mechanisms that produce these benefits have so far identified specific cellular and molecular responses in many brain cell types including neurons, microglia, astrocytes, oligodendrocytes, and the brain’s blood vessels. Last year, for instance, the lab reported in Nature that 40Hz audio and visual stimulation induced interneurons in mice to increase release of the peptide VIP, prompting increased clearance of amyloid from brain tissue via the brain’s glymphatic “plumbing” system.

Meanwhile, at MIT and at the MIT spinoff company Cognito Therapeutics, phase II clinical studies have shown that people with Alzheimer’s exposed to 40Hz light and sound experienced a significant slowing of brain atrophy and improvements on some cognitive measures, compared to untreated controls. Cognito, which has also measured significant preservation of the brain’s “white matter” in volunteers, has been conducting a pivotal, nationwide phase III clinical trial of sensory gamma stimulation for more than a year.

“Neuroscientists often lament that it is a great time to have AD [Alzheimer’s disease] if you are a mouse,” Park and Tsai wrote in the review. “Our ultimate goal, therefore, is to translate GENUS discoveries into a safe, accessible, and noninvasive therapy for AD patients.” The MIT team often refers to 40Hz stimulation as “GENUS” for Gamma Entrainment Using Sensory Stimulation.

A growing field

As Tsai’s collaboration, which includes MIT colleagues Edward Boyden and Emery N. Brown, has published its results, many other labs have produced studies adding to the evidence that various methods of noninvasive gamma sensory stimulation can combat Alzheimer’s pathology. Among many examples cited in the new review, in 2024 a research team in China independently corroborated that 40Hz sensory stimulation increases glymphatic fluid flows in mice. In another example, a Harvard Medical School-based team in 2022 showed that 40Hz gamma stimulation using Transcranial Alternating Current Stimulation significantly reduced the burden of tau in three out of four human volunteers. And in another study involving more than 100 people, researchers in Scotland in 2023 used audio and visual gamma stimulation (at 37.5Hz) to improve memory recall.

Open questions

Amid the growing number of publications describing preclinical studies with mice and clinical trials with people, open questions remain, Tsai and Park acknowledge. The MIT team and others are still exploring the cellular and molecular mechanisms that underlie GENUS’s effects. Tsai says her lab is looking at other neuropeptide and neuromodulatory systems to better understand the cascade of events linking sensory stimulation to the observed cellular responses. Meanwhile, the nature of how some cells, such as microglia, respond to gamma stimulation and how that affects pathology remains unclear, Tsai adds.

Even with a national phase III clinical trial underway, it is still important to investigate these fundamental mechanisms, Tsai says, because new insights into how noninvasive gamma stimulation affects the brain could improve and expand its therapeutic potential.

“The more we understand the mechanisms, the more we will have good ideas about how to further optimize the treatment,” Tsai says. “And the more we understand its action and the circuits it affects, the more we will know beyond Alzheimer’s disease what other neurological disorders will benefit from this.”

Indeed, the review points to studies at MIT and other institutions providing at least some evidence that GENUS might be able to help with Parkinson’s disease, stroke, anxiety, epilepsy, and the cognitive side effects of chemotherapy and conditions that reduce myelin, such as multiple sclerosis. Tsai’s lab has been studying whether it can help with Down syndrome as well.

The open questions may help define the next decade of GENUS research.

This is a current list of where and when I am scheduled to speak:

• I’m speaking at the Rossfest Symposium in Cambridge, UK, on March 25, 2025.
• I’m speaking at the University of Toronto’s Rotman School of Management in Toronto, Canada, on April 3, 2025.

The list is maintained on this page.

There is a new botnet that is infecting TP-Link routers:

The botnet can lead to command injection which then makes remote code execution (RCE) possible so that the malware can spread itself across the internet automatically. This high severity security flaw (tracked as CVE-2023-1389) has also been used to spread other malware families as far back as April 2023 when it was used in the Mirai botnet malware attacks. The flaw also linked to the Condi and AndroxGh0st malware attacks.

[…]

Of the thousands of infected devices, the majority of them are concentrated in Brazil, Poland, the United Kingdom, Bulgaria and Turkey; with the botnet targeting manufacturing, medical/healthcare, services and technology organizations in the United States, Australia, China and Mexico...

Defense Secretary Pete Hegseth wants to end the Defense Department’s climate efforts. Some experts say the move could hurt military readiness.

The proposal has attracted support on both sides of the aisle, even as the insurance industry has fought aggressively against it.

The prime minister-designate has said he will kill the unpopular climate policy.

Environmental groups are warning Congress that fossil fuel companies may ask for new protections.

Patients recovering from lung cancer remained admitted for about two days longer when fires raged nearby.

The California agency said Wednesday it's working with the Legislature, which is concurrently weighing whether to extend the program past 2030.