One in every eight people — 970 million globally — live with mental illness, according to the World Health Organization, with depression and anxiety being the most common mental health conditions worldwide. Existing therapies for complex psychiatric disorders like depression, anxiety, and schizophrenia have limitations, and federal funding to address these shortcomings is growing increasingly uncertain.

Patricia and James Poitras ’63 have committed $8 million to the Poitras Center for Psychiatric Disorders Research to launch pioneering research initiatives aimed at uncovering the brain basis of major mental illness and accelerating the development of novel treatments.

“Federal funding rarely supports the kind of bold, early-stage research that has the potential to transform our understanding of psychiatric illness. Pat and I want to help fill that gap — giving researchers the freedom to follow their most promising leads, even when the path forward isn’t guaranteed,” says James Poitras, who is chair of the McGovern Institute for Brain Research board.

Their latest gift builds upon their legacy of philanthropic support for psychiatric disorders research at MIT, which now exceeds $46 million.

“With deep gratitude for Jim and Pat’s visionary support, we are eager to launch a bold set of studies aimed at unraveling the neural and cognitive underpinnings of major mental illnesses,” says Professor Robert Desimone, director of the McGovern Institute, home to the Poitras Center. “Together, these projects represent a powerful step toward transforming how we understand and treat mental illness.”

A legacy of support

Soon after joining the McGovern Institute Leadership Board in 2006, the Poitrases made a $20 million commitment to establish the Poitras Center for Psychiatric Disorders Research at MIT. The center’s goal, to improve human health by addressing the root causes of complex psychiatric disorders, is deeply personal to them both.

“We had decided many years ago that our philanthropic efforts would be directed towards psychiatric research. We could not have imagined then that this perfect synergy between research at MIT’s McGovern Institute and our own philanthropic goals would develop,” recalls Patricia. 

The center supports research at the McGovern Institute and collaborative projects with institutions such as the Broad Institute of MIT and Harvard, McLean Hospital, Mass General Brigham, and other clinical research centers. Since its establishment in 2007, the center has enabled advances in psychiatric research including the development of a machine learning “risk calculator” for bipolar disorder, the use of brain imaging to predict treatment outcomes for anxiety, and studies demonstrating that mindfulness can improve mental health in adolescents.

For the past decade, the Poitrases have also fueled breakthroughs in the lab of McGovern investigator and MIT Professor Feng Zhang, backing the invention of powerful CRISPR systems and other molecular tools that are transforming biology and medicine. Their support has enabled the Zhang team to engineer new delivery vehicles for gene therapy, including vehicles capable of carrying genetic payloads that were once out of reach. The lab has also advanced innovative RNA-guided gene engineering tools such as NovaIscB, published in Nature Biotechnology in May 2025. These revolutionary genome editing and delivery technologies hold promise for the next generation of therapies needed for serious psychiatric illness.

In addition to fueling research in the center, the Poitras family has gifted two endowed professorships — the James and Patricia Poitras Professor of Neuroscience at MIT, currently held by Feng Zhang, and the James W. (1963) and Patricia T. Poitras Professor of Brain and Cognitive Sciences at MIT, held by Guoping Feng — and an annual postdoctoral fellowship at the McGovern Institute.

New initiatives at the Poitras Center

The Poitras family’s latest commitment to the Poitras Center will launch an ambitious set of new projects that bring together neuroscientists, clinicians, and computational experts to probe underpinnings of complex psychiatric disorders including schizophrenia, anxiety, and depression. These efforts reflect the center’s core mission: to speed scientific discovery and therapeutic innovation in the field of psychiatric brain disorders research.

McGovern cognitive neuroscientists Evelina Fedorenko PhD ’07, an associate professor, and Nancy Kanwisher ’80, PhD ’86, the Walter A. Rosenblith Professor of Cognitive Neuroscience — in collaboration with psychiatrist Ann Shinn of McLean Hospital — will explore how altered inner speech and reasoning contribute to the symptoms of schizophrenia. They will collect functional MRI data from individuals diagnosed with schizophrenia and matched controls as they perform reasoning tasks. The goal is to identify the brain activity patterns that underlie impaired reasoning in schizophrenia, a core cognitive disruption in the disorder.

A complementary line of investigation will focus on the role of inner speech — the “voice in our head” that shapes thought and self-awareness. The team will conduct a large-scale online behavioral study of neurotypical individuals to analyze how inner speech characteristics correlate with schizophrenia-spectrum traits. This will be followed by neuroimaging work comparing brain architecture among individuals with strong or weak inner voices and people with schizophrenia, with the aim of discovering neural markers linked to self-talk and disrupted cognition.

A different project led by McGovern neuroscientist and MIT Associate Professor Mark Harnett and 2024–2026 Poitras Center Postdoctoral Fellow Cynthia Rais focuses on how ketamine — an increasingly used antidepressant — alters brain circuits to produce rapid and sustained improvements in mood. Despite its clinical success, ketamine’s mechanisms of action remain poorly understood. The Harnett lab is using sophisticated tools to track how ketamine affects synaptic communication and large-scale brain network dynamics, particularly in models of treatment-resistant depression. By mapping these changes at both the cellular and systems levels, the team hopes to reveal how ketamine lifts mood so quickly — and inform the development of safer, longer-lasting antidepressants.

Guoping Feng is leveraging a new animal model of depression to uncover the brain circuits that drive major depressive disorder. The new animal model provides a powerful system for studying the intricacies of mood regulation. Feng’s team is using state-of-the-art molecular tools to identify the specific genes and cell types involved in this circuit, with the goal of developing targeted treatments that can fine-tune these emotional pathways.

“This is one of the most promising models we have for understanding depression at a mechanistic level,” says Feng, who is also associate director of the McGovern Institute. “It gives us a clear target for future therapies.”

Another novel approach to treating mood disorders comes from the lab of James DiCarlo, the Peter de Florez Professor of Neuroscience at MIT, who is exploring the brain’s visual-emotional interface as a therapeutic tool for anxiety. The amygdala, a key emotional center in the brain, is heavily influenced by visual input. DiCarlo’s lab is using advanced computational models to design visual scenes that may subtly shift emotional processing in the brain — essentially using sight to regulate mood. Unlike traditional therapies, this strategy could offer a noninvasive, drug-free option for individuals suffering from anxiety.

Together, these projects exemplify the kind of interdisciplinary, high-impact research that the Poitras Center was established to support.

“Mental illness affects not just individuals, but entire families who often struggle in silence and uncertainty,” adds Patricia Poitras. “Our hope is that Poitras Center scientists will continue to make important advancements and spark novel treatments for complex mental health disorders and, most of all, give families living with these conditions a renewed sense of hope for the future.”

A new and powerful particle detector just passed a critical test in its goal to decipher the ingredients of the early universe.

The sPHENIX detector is the newest experiment at Brookhaven National Laboratory’s Relativistic Heavy Ion Collider (RHIC) and is designed to precisely measure products of high-speed particle collisions. From the aftermath, scientists hope to reconstruct the properties of quark-gluon plasma (QGP) — a white-hot soup of subatomic particles known as quarks and gluons that is thought to have sprung into existence in the few microseconds following the Big Bang. Just as quickly, the mysterious plasma disappeared, cooling and combining to form the protons and neutrons that make up today’s ordinary matter.

Now, the sPHENIX detector has made a key measurement that proves it has the precision to help piece together the primordial properties of quark-gluon plasma.

In a paper in the Journal of High Energy Physics, scientists including physicists at MIT report that sPHENIX precisely measured the number and energy of particles that streamed out from gold ions that collided at close to the speed of light.

Straight ahead

This test is considered in physics to be a “standard candle,” meaning that the measurement is a well-established constant that can be used to gauge a detector’s precision.

In particular, sPHENIX successfully measured the number of charged particles that are produced when two gold ions collide, and determined how this number changes when the ions collide head-on, versus just glancing by. The detector’s measurements revealed that head-on collisions produced 10 times more charged particles, which were also 10 times more energetic, compared to less straight-on collisions.

“This indicates the detector works as it should,” says Gunther Roland, professor of physics at MIT, who is a member and former spokesperson for the sPHENIX Collaboration. “It’s as if you sent a new telescope up in space after you’ve spent 10 years building it, and it snaps the first picture. It’s not necessarily a picture of something completely new, but it proves that it’s now ready to start doing new science.”

“With this strong foundation, sPHENIX is well-positioned to advance the study of the quark-gluon plasma with greater precision and improved resolution,” adds Hao-Ren Jheng, a graduate student in physics at MIT and a lead co-author of the new paper. “Probing the evolution, structure, and properties of the QGP will help us reconstruct the conditions of the early universe.”

The paper’s co-authors are all members of the sPHENIX Collaboration, which comprises over 300 scientists from multiple institutions around the world, including Roland, Jheng, and physicists at MIT’s Bates Research and Engineering Center.

“Gone in an instant”

Particle colliders such as Brookhaven’s RHIC are designed to accelerate particles at “relativistic” speeds, meaning close to the speed of light. When these particles are flung around in opposite, circulating beams and brought back together, any smash-ups that occur can release an enormous amount of energy. In the right conditions, this energy can very briefly exist in the form of quark-gluon plasma — the same stuff that sprung out of the Big Bang.

Just as in the early universe, quark-gluon plasma doesn’t hang around for very long in particle colliders. If and when QGP is produced, it exists for just 10 to the minus 22, or about a sextillionth, of a second. In this moment, quark-gluon plasma is incredibly hot, up to several trillion degrees Celsius, and behaves as a “perfect fluid,” moving as one entity rather than as a collection of random particles. Almost immediately, this exotic behavior disappears, and the plasma cools and transitions into more ordinary particles such as protons and neutrons, which stream out from the main collision.

“You never see the QGP itself — you just see its ashes, so to speak, in the form of the particles that come from its decay,” Roland says. “With sPHENIX, we want to measure these particles to reconstruct the properties of the QGP, which is essentially gone in an instant.”

“One in a billion”

The sPHENIX detector is the next generation of Brookhaven’s original Pioneering High Energy Nuclear Interaction eXperiment, or PHENIX, which measured collisions of heavy ions generated by RHIC. In 2021, sPHENIX was installed in place of its predecessor, as a faster and more powerful version, designed to detect quark-gluon plasma’s more subtle and ephemeral signatures.

The detector itself is about the size of a two-story house and weighs around 1,000 tons. It sits at the intersection of RHIC’s two main collider beams, where relativistic particles, accelerated from opposite directions, meet and collide, producing particles that fly out into the detector. The sPHENIX detector is able to catch and measure 15,000 particle collisions per second, thanks to its novel, layered components, including the MVTX, or micro-vertex — a subdetector that was designed, built, and installed by scientists at MIT’s Bates Research and Engineering Center.

Together, the detector’s systems enable sPHENIX to act as a giant 3D camera that can track the number, energy, and paths of individual particles during an explosion of particles generated by a single collision.

“SPHENIX takes advantage of developments in detector technology since RHIC switched on 25 years ago, to collect data at the fastest possible rate,” says MIT postdoc Cameron Dean, who was a main contributor to the new study’s analysis. “This allows us to probe incredibly rare processes for the first time.”

In the fall of 2024, scientists ran the detector through the “standard candle” test to gauge its speed and precision. Over three weeks, they gathered data from sPHENIX as the main collider accelerated and smashed together beams of gold ions traveling at the speed of light. Their analysis of the data showed that sPHENIX accurately measured the number of charged particles produced in individual gold ion collisions, as well as the particles’ energies. What’s more, the detector was sensitive to a collision’s “head-on-ness,” and could observe that head-on collisions produced more particles with greater energy, compared to less direct collisions.

“This measurement provides clear evidence that the detector is functioning as intended,” Jheng says.

“The fun for sPHENIX is just beginning,” Dean adds. “We are currently back colliding particles and expect to do so for several more months. With all our data, we can look for the one-in-a-billion rare process that could give us insights on things like the density of QGP, the diffusion of particles through ultra-dense matter, and how much energy it takes to bind different particles together.”

This work was supported, in part, by the U.S. Department of Energy Office of Science, and the National Science Foundation.