Being placed in foster care is a necessary intervention for some children. But many advocates worry that kids can languish in foster care too long, with harmful effects for children who are temporarily unattached from a permanent family.

A new study co-authored by an MIT economist shows that an innovative Chilean program providing legal aid to children shortens the length of foster-care stays, returning them to families faster. In the process, it improves long-term social outcomes for kids and even reduces government spending on the foster care system.

“It was amazingly successful because the program got kids out of foster care about 30 percent faster,” says Joseph Doyle, an economist at the MIT Sloan School of Management, who helped lead the research. “Because foster care is expensive, that paid for the program by itself about four times over. If you improve the case management of kids in foster care, you can improve a child’s well-being and save money.”

The paper, “Effects of Enhanced Legal Aid in Child Welfare: Evidence from a Randomized Trial of Mi Abogado,” is published in the American Economic Review.

The authors are Ryan Cooper, a professor and director of government innovation at the University of Chicago; Doyle, who is the Erwin H. Schell Professor of Management at MIT Sloan; and Andrés P. Hojman, a professor at the Pontifical Catholic University of Chile.

Rigorous design

To conduct the study, the scholars examined the Chilean government’s new program “Mi Abogado” — meaning, “My Lawyer” — which provided enhanced legal support to children in foster care, as well as access to psychologists and social workers. Legal advocates in the program were given a reduced caseload, for one thing, to help them focus further on each individual case.

Chile introduced Mi Abogado in 2017, with a feature that made it ripe for careful study: The program randomizes most of the participants selected, as part of how it was rolled out. From the pool of children in the foster care system, randomly being part of the program makes it easier to identify its causal impact on later outcomes.

“Very few foster-care redesigns are evaluated in such a rigorous way, and we need more of this innovative approach to policy improvement,” Doyle notes.

The experiment included 1,781 children who were in Chile’s foster care program in 2019, with 581 selected for the Mi Abogado services; it tracked their trajectories over more than two years. Almost all the participants were in group foster-care homes.

In addition to reduced time spent in foster care, the Chilean data showed that children in the Mi Abogado program had a subsequent 30 percent reduction in terms of contact with the criminal justice system and a 5 percent increase in school attendance, compared to children in foster care who did not participate in the program.

“They were getting involved with crime less and attending school more,” Doyle says.

As powerful as the results appear, Doyle acknowledges that he would like to be able to analyze further which elements of the Mi Abogado program had the biggest impact — legal help, counseling and therapy, or other factors.

“We would like to see more about what exactly they are doing for children to speed their exit from care,” Doyle says. “Is it mostly about therapy? Is it working with judges and cutting through red tape? We think the lawyer is a very important part. But the results suggest it is not just the lawyer that improves outcomes.”

More programs in other places?

The current paper is one of many studies Doyle has developed during his career that relate to foster care and related issues. In another forthcoming paper, Doyle and some co-authors find that about 5 percent of U.S. children spend some time in foster care — a number that appears to be fairly common internationally, too.

“People don’t appreciate how common child protective services and foster care are,” Doyle says. Moreover, he adds, “Children involved in these systems are particularly vulnerable.”

With a variety of U.S. jurisdictions running their own foster-care systems, Doyle notes that many people have the opportunity to usefully learn about the Mi Abogado program and consider if its principles might be worth testing. And while that requires some political will, Doyle expresses optimism that policymakers might be open to new ideas.

“It’s not really a partisan issue,” Doyle says. “Most people want to help protect kids, and, if an intervention is needed for kids, have an interest in making the intervention run well.”

After all, he notes, the impact of the Mi Abogado program appears to be both substantial and lasting, making it an interesting example to consider.

“Here we have a case where the child outcomes are improved and the government saved money,” Doyle observes. “I’d like to see more experimentation with programs like this in other places.”

Support for the research was provided in part by the MIT Sloan Latin America Office. Chile’s Studies Department of the Ministry of Education made data available from the education system.

Inspired by the “Harry Potter” stories and the Disney Channel show “Wizards of Waverly Place,” 7-year-old Sabrina Corsetti emphatically declared to her parents one afternoon that she was, in fact, a wizard.

“My dad turned to me and said that, if I really wanted to be a wizard, then I should become a physicist. Physicists are the real wizards of the world,” she recalls.

That conversation stuck with Corsetti throughout her childhood, all the way up to her decision to double-major in physics and math in college, which set her on a path to MIT, where she is now a graduate student in the Department of Electrical Engineering and Computer Science.

While her work may not involve incantations or magic wands, Corsetti’s research centers on an area that often produces astonishing results: integrated photonics. A relatively young field, integrated photonics involves building computer chips that route light instead of electricity, enabling compact and scalable solutions for applications ranging from communications to sensing.

Corsetti and her collaborators in the Photonics and Electronics Research Group, led by Professor Jelena Notaros, develop chip-sized devices which enable innovative applications that push the boundaries of what is possible in optics.

For instance, Corsetti and the team developed a chip-based 3D printer, small enough to sit in the palm of one’s hand, that emits a reconfigurable beam of light into resin to create solid shapes. Such a device could someday enable a user to rapidly fabricate customized, low-cost objects on the go.

She also contributed to creating a miniature “tractor beam” that uses a beam of light to capture and manipulate biological particles using a chip. This could help biologists study DNA or investigate the mechanisms of disease without contaminating tissue samples.

More recently, Corsetti has been working on a project in collaboration with MIT Lincoln Laboratory, focused on trapped-ion quantum computing, which involves the manipulation of ions to store and process quantum information.

“Our team has a strong focus on designing devices and systems that interact with the environment. The opportunity to join a new research group, led by a supportive and engaged advisor, that works on projects with a lot of real-world impacts, is primarily what drew me to MIT,” Corsetti says.

Embracing challenges

Years before she set foot in a research lab, Corsetti was a science- and math-focused kid growing up with her parents and younger brother in the suburbs of Chicago, where her family operates a structural steelwork company.

Throughout her childhood, her teachers fostered her love of learning, from her early years in the Frankfort 157-C school district through her time at the Lincoln-Way East High School.

She enjoyed working on science experiments outside the classroom and relished the chance to tackle complex conundrums during independent study projects curated by her teachers (like calculating the math behind the Brachistochrone Curve, or the shortest path between two points, which was famously solved by Isaac Newton).

Corsetti decided to double-major in physics and math at the University of Michigan after graduating from high school a year early.

“When I went to the University of Michigan, I couldn’t wait to get started. I enrolled in the toughest math and physics track right off the bat,” she recalls.

But Corsetti soon found that she had bitten off a bit more than she could chew. A lot of her tough undergraduate courses assumed students had prior knowledge from AP physics and math classes, which Corsetti hadn’t taken because she graduated early.

She met with professors, attended office hours, and tried to pick up the lessons she had missed, but felt so discouraged she contemplated switching majors. Before she made the switch, Corsetti decided to try working in a physics lab to see if she liked a day in the life of a researcher.

After joining Professor Wolfgang Lorenzon’s lab at Michigan, Corsetti spent hours working with grad students and postdocs on a hands-on project to build cells that would hold liquid hydrogen for a particle physics experiment.

As they collaborated for hours at a time to roll material into tubes, she peppered the older students with questions about their experiences in the field.

“Being in the lab made me fall in love with physics. I really enjoyed that environment, working with my hands, and working with people as part of a bigger team,” she says.

Her affinity for hands-on lab work was amplified a few years later when she met Professor Tom Schwarz, her research advisor for the rest of her time at Michigan.

Following a chance conversation with Schwarz, she applied to a research abroad program at CERN in Switzerland, where she was mentored by Siyuan Sun. There, she had the opportunity to join thousands of physicists and engineers on the ATLAS project, writing code and optimizing circuits for new particle-detector technologies.

“That was one of the most transformative experiences of my life. After I came back to Michigan, I was ready to spend my career focusing on research,” she says.

Hooked on photonics

Corsetti began applying to graduate schools but decided to shift focus from the more theoretical particle physics to electrical engineering, with an interest in conducting hands-on chip-design and testing research.

She applied to MIT with a focus on standard electronic-chip design, so it came as a surprise when Notaros reached out to her to schedule a Zoom call. At the time, Corsetti was completely unfamiliar with integrated photonics. However, after one conversation with the new professor, she was hooked.

“Jelena has an infectious enthusiasm for integrated photonics,” she recalls. “After those initial conversations, I took a leap of faith.”

Corsetti joined Notaros’ team as it was just getting started. Closely mentored by a senior student, Milica Notaros, she and her cohort grew immersed in integrated photonics.

Over the years, she’s particularly enjoyed the collaborative and close-knit nature of the lab and how the work involves so many different aspects of the experimental process, from design to simulation to analysis to hardware testing.

“An exciting challenge that we’re always running up against is new chip-fabrication requirements. There is a lot of back-and-forth between new application areas that demand new fabrication technologies, followed by improved fabrication technologies motivating additional application areas. That cycle is constantly pushing the field forward,” she says.

Corsetti plans to stay at the cutting edge of the field after graduation as an integrated-photonics researcher in industry or at a national lab. She would like to focus on trapped-ion quantum computing, which scientists are rapidly scaling up toward commercially viable systems, or other high-performance computing applications.

“You really need accelerated computing for any modern research area. It would be exciting and rewarding to contribute to high-performance computing that can enable a lot of other interesting research areas,” she says.

Paying it forward

In addition to making an impact with research, Corsetti is focused on making a personal impact in the lives of others. Through her involvement in MIT Graduate Hillel, she joined the Jewish Big Brothers Big Sisters of Boston, where she volunteers for the friend-to-friend program.

Participating in the program, which pairs adults who have disabilities with friends in the community for fun activities like watching movies or painting has been an especially uplifting and gratifying experience for Corsetti.

She’s also enjoyed the opportunity to support, mentor, and bond with her fellow MIT EECS students, drawing on the advice she’s received throughout her own academic journey.

“Don’t trust feelings of imposter syndrome,” she advises others. “Keep moving forward, ask for feedback and help, and be confident that you will reach a point where you can make meaningful contributions to a team.”

Outside the lab, she enjoys playing classical music on the clarinet (her favorite piece is Leonard Bernstein’s famous overture to “Candide”), reading, and caring for a family of fish in her aquarium.

Evan Kharasch, professor of anesthesiology and vice chair for innovation at Duke University, has developed two approaches that may aid in fentanyl addiction recovery. After attending MIT’s Substance Use Disorders (SUD) Ventures Bootcamp, he’s committed to bringing them to market.

Illicit fentanyl addiction is still a national emergency in the United States, fueled by years of opioid misuse. As opioid prescriptions fell by 50 percent over 15 years, many turned to street drugs. Among those drugs, fentanyl stands out for its potency — just 2 milligrams can be fatal — and its low production cost. Often mixed with other drugs, it contributed to a large portion of over 80,000 overdose deaths in 2024. It has been particularly challenging to treat with currently available medications for opioid use disorder.  

​​As an anesthesiologist, Kharasch is highly experienced with opioids, including methadone, one of only three drugs approved in the United States for treating opioid use disorder. Methadone is a key option for managing fentanyl use. It’s employed to transition patients off fentanyl and to support ongoing maintenance, but access is limited, with only 20 percent of eligible patients receiving it. Initiating and adjusting methadone treatment can take weeks due to its clinical characteristics, often causing withdrawal and requiring longer hospital stays. Maintenance demands daily visits to one of just over 2,000 clinics, disrupting work or study and leading most patients to drop out after a few months.

To tackle these challenges, Kharasch developed two novel methadone formulations: one for faster absorption to cut initiation time from weeks to days — or even hours — and one to slow elimination, thereby potentially requiring only weekly, rather than daily, dosing. As a clinician, scientist, and entrepreneur, he sees the science as demanding, but bringing these treatments to patients presents an even greater challenge. Kharasch learned about the SUD Ventures Bootcamp, part of MIT Open Learning, as a recipient of research funding from the National Institute on Drug Abuse (NIDA). He decided to apply to bridge the gap in his expertise and was selected to attend as a fellow.

Each year, the SUD Ventures Bootcamp unites innovators — including scientists, entrepreneurs, and medical professionals — to develop bold, cross-disciplinary solutions to substance use disorders. Through online learning and an intensive one-week in-person bootcamp, teams tackle challenges in different “high priority” areas. Guided by experts in science, entrepreneurship, and policy, they build and pitch ventures aimed at real-world impact. Beyond the multidisciplinary curriculum, the program connects people deeply committed to this space and equipped to drive progress.

Throughout the program, Kharasch’s concepts were validated by the invited industry experts, who highlighted the potential impact of a longer-acting methadone formulation, particularly in correctional settings. Encouragement from MIT professors, coaches, and peers energized Kharasch to fully pursue commercialization. He has already begun securing intellectual property rights, validating the regulatory pathway through the U.S Food and Drug Administration, and gathering market and patient feedback.

The SUD Ventures Bootcamp, he says, both activated and validated his passion for bringing these innovations to patients. “After many years of basic, translational and clinical research on methadone all — supported by NIDA — I experienced that a ha moment of recognizing a potential opportunity to apply the findings to benefit patients at scale,” Kharasch says. “The NIDA-sponsored participation in the MIT SUD Ventures Bootcamp was the critical catalyst which ignited the inspiration and commitment to pursue commercializing our research findings into better treatments for opioid use disorder.”

As next steps, Kharasch is seeking an experienced co-founder and finalizing IP protections. He remains engaged with the SUD Ventures network as mentors, industry experts, and peers offer help with advancing this needed solution to market. For example, the program's mentor, Nat Sims, the Newbower/Eitan Endowed Chair in Biomedical Technology Innovation at Massachusetts General Hospital (MGH) and a fellow anesthesiologist, has helped Kharasch arrange technology validation conversations within the MGH ecosystem and the drug development community.

“Evan’s collaboration with the MGH ecosystem can help define an optimum process for commercializing these innovations — identifying who would benefit, how they would benefit, and who is willing to pilot the product once it’s available,” says Sims.

Kharasch has also presented his project in the program’s webinar series. Looking ahead, Kharasch hopes to involve MIT Sloan School of Management students in advancing his project through health care entrepreneurship classes, continuing the momentum that began with the SUD Ventures Bootcamp.

The program and its research are supported by the NIDA of the National Institutes of Health. Cynthia Breazeal, a professor of media arts and sciences at the MIT Media Lab and dean for digital learning at MIT Open Learning, serves as the principal investigator on the grant.

Gitanjali Rao, a rising junior at MIT majoring in biological engineering, has been named the first-ever recipient of the Stephen Hawking Junior Medal for Science Communication. This award, presented by the Starmus Festival, is a new category of the already prestigious award created by the late theoretical physicist, cosmologist, and author Stephen Hawking and the Starmus Festival.

“I spend a lot of time in labs,” says Rao, highlighting her Undergraduate Research Opportunities Program project in the Langer Lab. Along with her curiosity to explore, she also has a passion for helping others understand what happens inside the lab. “We very rarely discuss why science communication is important,” she says. “Stephen Hawking was incredible at that.”

Rao is the inventor of Epione, a device for early diagnosis of prescription opioid addiction, and Kindly, an anti-cyber-bullying service powered by AI and natural language processing. Kindly is now a United Nations Children's Fund “Digital Public Good” service and is accessible worldwide. These efforts, among others, brought her to the attention of the Starmus team.

The award ceremony was held last April at the Kennedy Center in Washington, where Rao gave a speech and met acclaimed scientists, artists, and musicians. “It was one for the books,” she says. “I met Brian May from Queen — he's a physicist.” Rao is also a musician in her own right — she plays bass guitar and piano, and she's been learning to DJ at MIT. “Starmus” is a portmanteau of “stars” and “music.”

Originally from Denver, Colorado, Rao attended a STEM-focused school before MIT. Looking ahead, she's open to graduate school, and dreams of launching a biotech startup when the right idea comes.

The medal comes with an internship opportunity that Rao hopes to use for fieldwork or experience in the pharmaceutical industry. She’s already secured a summer internship at Moderna, and is considering spending Independent Activities Period abroad. “Hopefully, I'll have a better idea in the next few months.”
 

The International Architecture Exhibition of La Biennale di Venezia holds up a mirror to the industry — not only reflecting current priorities and preoccupations, but also projecting an agenda for what might be possible. 

Curated by Carlo Ratti, MIT professor of practice of urban technologies and planning, this year’s exhibition (“Intelligens. Natural. Artificial. Collective”) proposes a “Circular Economy Manifesto” with the goal to support the “development and production of projects that utilize natural, artificial, and collective intelligence to combat the climate crisis.” 

Designers and architects will quickly recognize the paradox of this year’s theme. Global architecture festivals have historically had a high carbon footprint, using vast amounts of energy, resources, and materials to build and transport temporary structures that are later discarded. This year’s unprecedented emphasis on waste elimination and carbon neutrality challenges participants to reframe apparent limitations into creative constraints. In this way, the Biennale acts as a microcosm of current planetary conditions — a staging ground to envision and practice adaptive strategies.

VAMO (Vegetal, Animal, Mineral, Other)

When Ratti approached John Ochsendorf, MIT professor and founding director of MIT Morningside Academy of Design (MAD), with the invitation to interpret the theme of circularity, the project became the premise for a convergence of ideas, tools, and know-how from multiple teams at MIT and the wider MIT community. 

The Digital Structures research group, directed by Professor Caitlin Mueller, applied expertise in designing efficient structures of tension and compression. The Circular Engineering for Architecture research group, led by MIT alumna Catherine De Wolf at ETH Zurich, explored how digital technologies and traditional woodworking techniques could make optimal use of reclaimed timber. Early-stage startups — including companies launched by the venture accelerator MITdesignX — contributed innovative materials harnessing natural byproducts from vegetal, animal, mineral, and other sources. 

The result is VAMO (Vegetal, Animal, Mineral, Other), an ultra-lightweight, biodegradable, and transportable canopy designed to circle around a brick column in the Corderie of the Venice Arsenale — a historic space originally used to manufacture ropes for the city’s naval fleet. 

“This year’s Biennale marks a new radicalism in approaches to architecture,” says Ochsendorf. “It’s no longer sufficient to propose an exciting idea or present a stylish installation. The conversation on material reuse must have relevance beyond the exhibition space, and we’re seeing a hunger among students and emerging practices to have a tangible impact. VAMO isn’t just a temporary shelter for new thinking. It’s a material and structural prototype that will evolve into multiple different forms after the Biennale.”

Tension and compression

The choice to build the support structure from reclaimed timber and hemp rope called for a highly efficient design to maximize the inherent potential of comparatively humble materials. Working purely in tension (the spliced cable net) or compression (the oblique timber rings), the structure appears to float — yet is capable of supporting substantial loads across large distances. The canopy weighs less than 200 kilograms and covers over 6 meters in diameter, highlighting the incredible lightness that equilibrium forms can achieve. VAMO simultaneously showcases a series of sustainable claddings and finishes made from surprising upcycled materials — from coconut husks, spent coffee grounds, and pineapple peel to wool, glass, and scraps of leather. 

The Digital Structures research group led the design of structural geometries conditioned by materiality and gravity. “We knew we wanted to make a very large canopy,” says Mueller. “We wanted it to have anticlastic curvature suggestive of naturalistic forms. We wanted it to tilt up to one side to welcome people walking from the central corridor into the space. However, these effects are almost impossible to achieve with today's computational tools that are mostly focused on drawing rigid materials.”

In response, the team applied two custom digital tools, Ariadne and Theseus, developed in-house to enable a process of inverse form-finding: a way of discovering forms that achieve the experiential qualities of an architectural project based on the mechanical properties of the materials. These tools allowed the team to model three-dimensional design concepts and automatically adjust geometries to ensure that all elements were held in pure tension or compression.

“Using digital tools enhances our creativity by allowing us to choose between multiple different options and short-circuit a process that would have otherwise taken months,” says Mueller. “However, our process is also generative of conceptual thinking that extends beyond the tool — we’re constantly thinking about the natural and historic precedents that demonstrate the potential of these equilibrium structures.”

Digital efficiency and human creativity 

Lightweight enough to be carried as standard luggage, the hemp rope structure was spliced by hand and transported from Massachusetts to Venice. Meanwhile, the heavier timber structure was constructed in Zurich, where it could be transported by train — thereby significantly reducing the project’s overall carbon footprint. 

The wooden rings were fabricated using salvaged beams and boards from two temporary buildings in Switzerland — the Huber and Music Pavilions — following a pedagogical approach that De Wolf has developed for the Digital Creativity for Circular Construction course at ETH Zurich. Each year, her students are tasked with disassembling a building due for demolition and using the materials to design a new structure. In the case of VAMO, the goal was to upcycle the wood while avoiding the use of chemicals, high-energy methods, or non-biodegradable components (such as metal screws or plastics). 

“Our process embraces all three types of intelligence celebrated by the exhibition,” says De Wolf. “The natural intelligence of the materials selected for the structure and cladding; the artificial intelligence of digital tools empowering us to upcycle, design, and fabricate with these natural materials; and the crucial collective intelligence that unlocks possibilities of newly developed reused materials, made possible by the contributions of many hands and minds.”

For De Wolf, true creativity in digital design and construction requires a context-sensitive approach to identifying when and how such tools are best applied in relation to hands-on craftsmanship. 

Through a process of collective evaluation, it was decided that the 20-foot lower ring would be assembled with eight scarf joints using wedges and wooden pegs, thereby removing the need for metal screws. The scarf joints were crafted through five-axis CNC milling; the smaller, dual-jointed upper ring was shaped and assembled by hand by Nicolas Petit-Barreau, founder of the Swiss woodwork company Anku, who applied his expertise in designing and building yurts, domes, and furniture to the VAMO project. 

“While digital tools suited the repetitive joints of the lower ring, the upper ring’s two unique joints were more efficiently crafted by hand,” says Petit-Barreau. “When it comes to designing for circularity, we can learn a lot from time-honored building traditions. These methods were refined long before we had access to energy-intensive technologies — they also allow for the level of subtlety and responsiveness necessary when adapting to the irregularities of reused wood.”

A material palette for circularity

The structural system of a building is often the most energy-intensive; an impact dramatically mitigated by the collaborative design and fabrication process developed by MIT Digital Structures and ETH Circular Engineering for Architecture. The structure also serves to showcase panels made of biodegradable and low-energy materials — many of which were advanced through ventures supported by MITdesignX, a program dedicated to design innovation and entrepreneurship at MAD. 

“In recent years, several MITdesignX teams have proposed ideas for new sustainable materials that might at first seem far-fetched,” says Gilad Rosenzweig, executive director of MITdesignX. “For instance, using spent coffee grounds to create a leather-like material (Cortado), or creating compostable acoustic panels from coconut husks and reclaimed wool (Kokus). This reflects a major cultural shift in the architecture profession toward rethinking the way we build, but it’s not enough just to have an inventive idea. To achieve impact — to convert invention into innovation — teams have to prove that their concept is cost-effective, viable as a business, and scalable.”

Aligned with the ethos of MAD, MITdesignX assesses profit and productivity in terms of environmental and social sustainability. In addition to presenting the work of R&D teams involved in MITdesignX, VAMO also exhibits materials produced by collaborating teams at University of Pennsylvania’s Stuart Weitzman School of Design, Politecnico di Milano, and other partners, such as Manteco. 

The result is a composite structure that encapsulates multiple life spans within a diverse material palette of waste materials from vegetal, animal, and mineral forms. Panels of Ananasse, a material made from pineapple peels developed by Vérabuccia, preserve the fruit’s natural texture as a surface pattern, while rehub repurposes fragments of multicolored Murano glass into a flexible terrazzo-like material; COBI creates breathable shingles from coarse wool and beeswax, and DumoLab produces fuel-free 3D-printable wood panels. 

A purpose beyond permanence 

Adriana Giorgis, a designer and teaching fellow in architecture at MIT, played a crucial role in bringing the parts of the project together. Her research explores the diverse network of factors that influence whether a building stands the test of time, and her insights helped to shape the collective understanding of long-term design thinking.

“As a point of connection between all the teams, helping to guide the design as well as serving as a project manager, I had the chance to see how my research applied at each level of the project,” Giorgis reflects. “Braiding these different strands of thinking and ultimately helping to install the canopy on site brought forth a stronger idea about what it really means for a structure to have longevity. VAMO isn’t limited to its current form — it’s a way of carrying forward a powerful idea into contemporary and future practice.”

What’s next for VAMO? Neither the attempt at architectural permanence associated with built projects, nor the relegation to waste common to temporary installations. After the Biennale, VAMO will be disassembled, possibly reused for further exhibitions, and finally relocated to a natural reserve in Switzerland, where the parts will be researched as they biodegrade. In this way, the lifespan of the project is extended beyond its initial purpose for human habitation and architectural experimentation, revealing the gradual material transformations constantly taking place in our built environment.

To quote Carlo Ratti’s Circular Economy Manifesto, the “lasting legacy” of VAMO is to “harness nature’s intelligence, where nothing is wasted.” Through a regenerative symbiosis of natural, artificial, and collective intelligence, could architectural thinking and practice expand to planetary proportions?

The Substance Use Disorders Ventures Bootcamp ignites innovators like Evan Kharasch to turn research breakthroughs into treatments for substance use disorder.

Often when we listen to music, we just instinctually enjoy it. Sometimes, though, it’s worth dissecting a song or other composition to figure out how it’s built.

Take the 1953 jazz standard “Satin Doll,” written by Duke Ellington and Billy Strayhorn, whose subtle structure rewards a close listening. As it happens, MIT Professor Emeritus Samuel Jay Keyser, a distinguished linguist and an avid trombonist on the side, has given the song careful scrutiny.

To Keyser, “Satin Doll” is a glittering example of what he calls the “same/except” construction in art. A basic rhyme, like “rent” and “tent,” is another example of this construction, given the shared rhyming sound and the different starting consonants.

In “Satin Doll,” Keyser observes, both the music and words feature a “same/except” structure. For instance, the rhythm of the first two bars of “Satin Doll” is the same as the second two bars, but the pitch goes up a step in bars three and four. An intricate pattern of this prevails throughout the entire body of “Satin Doll,” which Keyser calls “a musical rhyme scheme.”

When lyricist Johnny Mercer wrote words for “Satin Doll,” he matched the musical rhyme scheme. One lyric for the first four bars is, “Cigarette holder / which wigs me / Over her shoulder / she digs me.” Other verses follow the same pattern.

“Both the lyrics and the melody have the same rhyme scheme in their separate mediums, words and music, namely, A-B-A-B,” says Keyser. “That’s how you write lyrics. If you understand the musical rhyme scheme, and write lyrics to match that, you are introducing a whole new level of repetition, one that enhances the experience.”

Now, Keyser has a new book out about repetition in art and its cognitive impact on us, scrutinizing “Satin Doll” along with many other works of music, poetry, painting, and photography. The volume, “Play It Again, Sam: Repetition in the Arts,” is published by the MIT Press. The title is partly a play on Keyser’s name.

Inspired by the Margulis experiment

The genesis of “Play It Again, Sam” dates back several years, when Keyser encountered an experiment conducted by musicologist Elizabeth Margulis, described in her 2014 book, “On Repeat.” Margulis found that when she altered modern atonal compositions to add repetition to them, audiences ranging from ordinary listeners to music theorists preferred these edited versions to the original works.

“The Margulis experiment really caused the ideas to materialize,” Keyser says. He then examined repetition across art forms that featured research on associated cognitive activity, especially music, poetry, and the visual arts. For instance, the brain has distinct locations dedicated to the recognition of faces, places, and bodies. Keyser suggests this is why, prior to the advent of modernism, painting was overwhelmingly mimetic.

Ideally, he suggests, it will be possible to more comprehensively study how our brains process art — to see if encountering repetition triggers an endorphin release, say. For now, Keyser postulates that repetition involves what he calls the 4 Ps: priming, parallelism, prediction, and pleasure. Essentially, hearing or seeing a motif sets the stage for it to be repeated, providing audiences with satisfaction when they discover the repetition.

With remarkable range, Keyser vigorously analyzes how artists deploy repetition and have thought about it, from “Beowulf” to Leonard Bernstein, from Gustave Caillebotte to Italo Calvino. Some artworks do deploy identical repetition of elements, such as the Homeric epics; others use the “same/except” technique.

Keyser is deeply interested in visual art displaying the “same/except” concept, such as Andy Warhol’s famous “Campbell Soup Cans” painting. It features four rows of eight soup cans, which are all the same — except for the kind of soup on each can.

“Discovering this ‘same/except’ repetition in a work of art brings pleasure,” Keyser says.

But why is this? Multiple experimental studies, Keyser notes, suggest that repeated exposure of a subject to an image — such as an infant’s exposure to its mother’s face — helps create a bond of affection. This is the “mere exposure” phenomenon, posited by social psychologist Robert Zajonc, who as Keyser notes in the book, studied in detail “the repetition of an arbitrary stimulus and the mild affection that people eventually have for it.”

This tendency also helps explain why product manufacturers create ads with just the name of their products in ads: Seen often enough, the viewer bonds with the name. However the mechanism connecting repetition with pleasure works, and whatever its original function, Keyser argues that many artists have successfully tapped into it, grasping that audiences like repetition in poetry, painting, and music.

A shadow dog in Albuquerque

In the book, Keyser’s emphasis on repetition generates some distinctive interpretive positions. In one chapter, he digs into Lee Friendlander’s well-known photo, “Albuquerque, New Mexico,” a street scene with a jumble of signs, wires, and buildings, often interpreted in symbolic terms: It’s the American West frontier being submerged under postwar concrete and commerce.

Keyser, however, has a really different view of the Friendlander photo. There is a dog sitting near the middle of it; to the right is the shadow of a street sign. Keyser believes the shadow resembles the dog, and thinks it creates playful repetition in the photo.

“This particular photograph is really two photographs that rhyme,” Keyser says.“They’re the same, except one is the dog and one is the shadow. And that’s why that photograph is pleasurable, because you see that, even if you may not be fully aware of it. Sensing repetition in a work of art brings pleasure.”

“Play It Again, Sam” has received praise from arts practitioners, among others. George Darrah, principal drummer and arranger of the Boston Pops Orchestra, has called the book “extraordinary” in its “demonstration of the ways that poetry, music, painting, and photography engender pleasure in their audiences by exploiting the ability of the brain to detect repetition.” He adds that “Keyser has an uncanny ability to simplify complex ideas so that difficult material is easily understandable.”

In certain ways “Play It Again, Sam” contains the classic intellectual outlook of an MIT linguist. For decades, MIT-linked linguistics research has identified the universal structures of human language, revealing important similarities despite the seemingly wild variation of global languages. And here too, Keyser finds patterns that help organize an apparently boundless world of art. “Play It Again, Sam” is a hunt for structure.

Asked about this, Keyser acknowledges the influence of his longtime field on his current intellectual explorations, while noting that his insights about art are part of a greater investigation into our works and minds.

“I’m bringing a linguistic habit of mind to art,” Keyser says. “But I’m also pointing an analytical lens in the direction of natural predilections of the brain. The idea is to investigate how our aesthetic sense depends on the way the mind works. I’m trying to show how art can exploit the brain’s capacity to produce pleasure from non-art related functions.”

Using an inexpensive electrode coated with DNA, MIT researchers have designed disposable diagnostics that could be adapted to detect a variety of diseases, including cancer or infectious diseases such as influenza and HIV.

These electrochemical sensors make use of a DNA-chopping enzyme found in the CRISPR gene-editing system. When a target such as a cancerous gene is detected by the enzyme, it begins shearing DNA from the electrode nonspecifically, like a lawnmower cutting grass, altering the electrical signal produced.

One of the main limitations of this type of sensing technology is that the DNA that coats the electrode breaks down quickly, so the sensors can’t be stored for very long and their storage conditions must be tightly controlled, limiting where they can be used. In a new study, MIT researchers stabilized the DNA with a polymer coating, allowing the sensors to be stored for up to two months, even at high temperatures. After storage, the sensors were able to detect a prostate cancer gene that is often used to diagnose the disease.

The DNA-based sensors, which cost only about 50 cents to make, could offer a cheaper way to diagnose many diseases in low-resource regions, says Ariel Furst, the Paul M. Cook Career Development Assistant Professor of Chemical Engineering at MIT and the senior author of the study.

“Our focus is on diagnostics that many people have limited access to, and our goal is to create a point-of-use sensor. People wouldn’t even need to be in a clinic to use it. You could do it at home,” Furst says.

MIT graduate student Xingcheng Zhou is the lead author of the paper, published June 30 in the journal ACS Sensors. Other authors of the paper are MIT undergraduate Jessica Slaughter, Smah Riki ’24, and graduate student Chao Chi Kuo.

An inexpensive sensor

Electrochemical sensors work by measuring changes in the flow of an electric current when a target molecule interacts with an enzyme. This is the same technology that glucose meters use to detect concentrations of glucose in a blood sample.

The electrochemical sensors developed in Furst’s lab consist of DNA adhered to an inexpensive gold leaf electrode, which is laminated onto a sheet of plastic. The DNA is attached to the electrode using a sulfur-containing molecule known as a thiol.

In a 2021 study, Furst’s lab showed that they could use these sensors to detect genetic material from HIV and human papillomavirus (HPV). The sensors detect their targets using a guide RNA strand, which can be designed to bind to nearly any DNA or RNA sequence. The guide RNA is linked to an enzyme called Cas12, which cleaves DNA nonspecifically when it is turned on and is in the same family of proteins as the Cas9 enzyme used for CRISPR genome editing.

If the target is present, it binds to the guide RNA and activates Cas12, which then cuts the DNA adhered to the electrode. That alters the current produced by the electrode, which can be measured using a potentiostat (the same technology used in handheld glucose meters).

“If Cas12 is on, it’s like a lawnmower that cuts off all the DNA on your electrode, and that turns off your signal,” Furst says.

In previous versions of the device, the DNA had to be added to the electrode just before it was used, because DNA doesn’t remain stable for very long. In the new study, the researchers found that they could increase the stability of the DNA by coating it with a polymer called polyvinyl alcohol (PVA).

This polymer, which costs less than 1 cent per coating, acts like a tarp that protects the DNA below it. Once deposited onto the electrode, the polymer dries to form a protective thin film.

“Once it’s dried, it seems to make a very strong barrier against the main things that can harm DNA, such as reactive oxygen species that can either damage the DNA itself or break the thiol bond with the gold and strip your DNA off the electrode,” Furst says.

Successful detection

The researchers showed that this coating could protect DNA on the sensors for at least two months, and it could also withstand temperatures up to about 150 degrees Fahrenheit. After two months, they rinsed off the polymer and demonstrated that the sensors could still detect PCA3, a prostate cancer gene that can be found in urine.

This type of test could be used with a variety of samples, including urine, saliva, or nasal swabs. The researchers hope to use this approach to develop cheaper diagnostics for infectious diseases, such as HPV or HIV, that could be used in a doctor’s office or at home. This approach could also be used to develop tests for emerging infectious diseases, the researchers say.

A group of researchers from Furst’s lab was recently accepted into delta v, MIT’s student venture accelerator, where they hope to launch a startup to further develop this technology. Now that the researchers can create tests with a much longer shelf-life, they hope to begin shipping them to locations where they could be tested with patient samples.

“Our goal is to continue to test with patient samples against different diseases in real world environments,” Furst says. “Our limitation before was that we had to make the sensors on site, but now that we can protect them, we can ship them. We don’t have to use refrigeration. That allows us to access a lot more rugged or non-ideal environments for testing.”

The research was funded, in part, by the MIT Research Support Committee and a MathWorks Fellowship.

A new imaging technique developed by MIT researchers could enable quality-control robots in a warehouse to peer through a cardboard shipping box and see that the handle of a mug buried under packing peanuts is broken.

Their approach leverages millimeter wave (mmWave) signals, the same type of signals used in Wi-Fi, to create accurate 3D reconstructions of objects that are blocked from view.

The waves can travel through common obstacles like plastic containers or interior walls, and reflect off hidden objects. The system, called mmNorm, collects those reflections and feeds them into an algorithm that estimates the shape of the object’s surface.

This new approach achieved 96 percent reconstruction accuracy on a range of everyday objects with complex, curvy shapes, like silverware and a power drill. State-of-the-art baseline methods achieved only 78 percent accuracy.

In addition, mmNorm does not require additional bandwidth to achieve such high accuracy. This efficiency could allow the method to be utilized in a wide range of settings, from factories to assisted living facilities.

For instance, mmNorm could enable robots working in a factory or home to distinguish between tools hidden in a drawer and identify their handles, so they could more efficiently grasp and manipulate the objects without causing damage.

“We’ve been interested in this problem for quite a while, but we’ve been hitting a wall because past methods, while they were mathematically elegant, weren’t getting us where we needed to go. We needed to come up with a very different way of using these signals than what has been used for more than half a century to unlock new types of applications,” says Fadel Adib, associate professor in the Department of Electrical Engineering and Computer Science, director of the Signal Kinetics group in the MIT Media Lab, and senior author of a paper on mmNorm.

Adib is joined on the paper by research assistants Laura Dodds, the lead author, and Tara Boroushaki, and former postdoc Kaichen Zhou. The research was recently presented at the Annual International Conference on Mobile Systems, Applications and Services.

Reflecting on reflections

Traditional radar techniques send mmWave signals and receive reflections from the environment to detect hidden or distant objects, a technique called back projection.

This method works well for large objects, like an airplane obscured by clouds, but the image resolution is too coarse for small items like kitchen gadgets that a robot might need to identify.

In studying this problem, the MIT researchers realized that existing back projection techniques ignore an important property known as specularity. When a radar system transmits mmWaves, almost every surface the waves strike acts like a mirror, generating specular reflections.

If a surface is pointed toward the antenna, the signal will reflect off the object to the antenna, but if the surface is pointed in a different direction, the reflection will travel away from the radar and won’t be received.

“Relying on specularity, our idea is to try to estimate not just the location of a reflection in the environment, but also the direction of the surface at that point,” Dodds says.

They developed mmNorm to estimate what is called a surface normal, which is the direction of a surface at a particular point in space, and use these estimations to reconstruct the curvature of the surface at that point.

Combining surface normal estimations at each point in space, mmNorm uses a special mathematical formulation to reconstruct the 3D object.

The researchers created an mmNorm prototype by attaching a radar to a robotic arm, which continually takes measurements as it moves around a hidden item. The system compares the strength of the signals it receives at different locations to estimate the curvature of the object’s surface.

For instance, the antenna will receive the strongest reflections from a surface pointed directly at it and weaker signals from surfaces that don’t directly face the antenna.

Because multiple antennas on the radar receive some amount of reflection, each antenna “votes” on the direction of the surface normal based on the strength of the signal it received.

“Some antennas might have a very strong vote, some might have a very weak vote, and we can combine all votes together to produce one surface normal that is agreed upon by all antenna locations,” Dodds says.

In addition, because mmNorm estimates the surface normal from all points in space, it generates many possible surfaces. To zero in on the right one, the researchers borrowed techniques from computer graphics, creating a 3D function that chooses the surface most representative of the signals received. They use this to generate a final 3D reconstruction.

Finer details

The team tested mmNorm’s ability to reconstruct more than 60 objects with complex shapes, like the handle and curve of a mug. It generated reconstructions with about 40 percent less error than state-of-the-art approaches, while also estimating the position of an object more accurately.

Their new technique can also distinguish between multiple objects, like a fork, knife, and spoon hidden in the same box. It also performed well for objects made from a range of materials, including wood, metal, plastic, rubber, and glass, as well as combinations of materials, but it does not work for objects hidden behind metal or very thick walls.

“Our qualitative results really speak for themselves. And the amount of improvement you see makes it easier to develop applications that use these high-resolution 3D reconstructions for new tasks,” Boroushaki says.

For instance, a robot can distinguish between multiple tools in a box, determine the precise shape and location of a hammer’s handle, and then plan to pick it up and use it for a task. One could also use mmNorm with an augmented reality headset, enabling a factory worker to see lifelike images of fully occluded objects.

It could also be incorporated into existing security and defense applications, generating more accurate reconstructions of concealed objects in airport security scanners or during military reconnaissance.

The researchers want to explore these and other potential applications in future work. They also want to improve the resolution of their technique, boost its performance for less reflective objects, and enable the mmWaves to effectively image  through thicker occlusions.

“This work really represents a paradigm shift in the way we are thinking about these signals and this 3D reconstruction process. We’re excited to see how the insights that we’ve gained here can have a broad impact,” Dodds says.

This work is supported, in part, by the National Science Foundation, the MIT Media Lab, and Microsoft.

Imagine that you want to know the plot of a movie, but you only have access to either the visuals or the sound. With visuals alone, you’ll miss all the dialogue. With sound alone, you will miss the action. Understanding our biology can be similar. Measuring one kind of data — such as which genes are being expressed — can be informative, but it only captures one facet of a multifaceted story. For many biological processes and disease mechanisms, the entire “plot” can’t be fully understood without combining data types.

However, capturing both the “visuals and sound” of biological data, such as gene expression and cell structure data, from the same cells requires researchers to develop new approaches. They also have to make sure that the data they capture accurately reflects what happens in living organisms, including how cells interact with each other and their environments.

Whitehead Institute for Biomedical Research and Harvard University researchers have taken on these challenges and developed Perturb-Multimodal (Perturb-Multi), a powerful new approach that simultaneously measures how genetic changes such as turning off individual genes affect both gene expression and cell structure in intact liver tissue. The method, described in Cell on June 12, aims to accelerate discovery of how genes control organ function and disease.

The research team, led by Whitehead Institute Member Jonathan Weissman and then-graduate student in his lab Reuben Saunders, along with Xiaowei Zhuang, the David B. Arnold Professor of Science at Harvard University, and then-postdoc in her lab Will Allen, created a system that can test hundreds of different genetic modifications within a single mouse liver while capturing multiple types of data from the same cells.

“Understanding how our organs work requires looking at many different aspects of cell biology at once,” Saunders says. “With Perturb-Multi, we can see how turning off specific genes changes not just what other genes are active, but also how proteins are distributed within cells, how cellular structures are organized, and where cells are located in the tissue. It’s like having multiple specialized microscopes all focused on the same experiment.”

“This approach accelerates discovery by both allowing us to test the functions of many different genes at once, and then for each gene, allowing us to measure many different functional outputs or cell properties at once — and we do that in intact tissue from animals,” says Zhuang, who is also a Howard Hughes Medical Institute (HHMI) investigator.

A more efficient approach to genetic studies

Traditional genetic studies in mice often turn off one gene and then observe what changes in that gene’s absence to learn about what the gene does. The researchers designed their approach to turn off hundreds of different genes across a single liver, while still only turning off one gene per cell — using what is known as a mosaic approach. This allowed them to study the roles of hundreds of individual genes at once in a single individual. The researchers then collected diverse types of data from cells across the same liver to get a full picture of the consequences of turning off the genes.

“Each cell serves as its own experiment, and because all the cells are in the same animal, we eliminate the variability that comes from comparing different mice,” Saunders says. “Every cell experiences the same physiological conditions, diet, and environment, making our comparisons much more precise.”

“The challenge we faced was that tissues, to perform their functions, rely on thousands of genes, expressed in many different cells, working together. Each gene, in turn, can control many aspects of a cell’s function. Testing these hundreds of genes in mice using current methods would be extremely slow and expensive — near impossible, in practice.” Allen says.

Revealing new biology through combined measurements

The team applied Perturb-Multi to study genetic controls of liver physiology and function. Their study led to discoveries in three important aspects of liver biology: fat accumulation in liver cells — a precursor to liver disease; stress responses; and hepatocyte zonation (how liver cells specialize, assuming different traits and functions, based on their location within the liver).

One striking finding emerged from studying genes that, when disrupted, cause fat accumulation in liver cells. The imaging data revealed that four different genes all led to similar fat droplet accumulation, but the sequencing data showed they did so through three completely different mechanisms.

“Without combining imaging and sequencing, we would have missed this complexity entirely,” Saunders says. “The imaging told us which genes affect fat accumulation, while the sequencing revealed whether this was due to increased fat production, cellular stress, or other pathways. This kind of mechanistic insight could be crucial for developing targeted therapies for fatty liver disease.”

The researchers also discovered new regulators of liver cell zonation. Unexpectedly, the newly discovered regulators include genes involved in modifying the extracellular matrix — the scaffolding between cells. “We found that cells can change their specialized functions without physically moving to a different zone,” Saunders says. “This suggests that liver cell identity is more flexible than previously thought.”

Technical innovation enables new science

Developing Perturb-Multi required solving several technical challenges. The team created new methods for preserving the content of interest in cells — RNA and proteins — during tissue processing, for collecting many types of imaging data and single-cell gene expression data from tissue samples that have been fixed with a preservative, and for integrating multiple types of data from the same cells.

“Overcoming the inherent complexity of biology in living animals required developing new tools that bridge multiple disciplines — including, in this case, genomics, imaging, and AI,” Allen says.

The two components of Perturb-Multi — the imaging and sequencing assays — together, applied to the same tissue, provide insights that are unattainable through either assay alone.

“Each component had to work perfectly while not interfering with the others,” says Weissman, who is also a professor of biology at MIT and an HHMI investigator. “The technical development took considerable effort, but the payoff is a system that can reveal biology we simply couldn’t see before.”

Expanding to new organs and other contexts

The researchers plan to expand Perturb-Multi to other organs, including the brain, and to study how genetic changes affect organ function under different conditions like disease states or dietary changes.

“We’re also excited about using the data we generate to train machine learning models,” adds Saunders. “With enough examples of how genetic changes affect cells, we could eventually predict the effects of mutations without having to test them experimentally — a ‘virtual cell’ that could accelerate both research and drug development.”

“Perturbation data are critical for training such AI models and the paucity of existing perturbation data represents a major hindrance in such ‘virtual cell’ efforts,” Zhuang says. “We hope Perturb-Multi will fill this gap by accelerating the collection of perturbation data.”

The approach is designed to be scalable, with the potential for genome-wide studies that test thousands of genes simultaneously. As sequencing and imaging technologies continue to improve, the researchers anticipate that Perturb-Multi will become even more powerful and accessible to the broader research community.

“Our goal is to keep scaling up. We plan to do genome-wide perturbations, study different physiological conditions, and look at different organs,” says Weissman. “That we can now collect so many types of data from so many cells, at speed, is going to be critical for building AI models like virtual cells, and I think it’s going to help us answer previously unsolvable questions about health and disease.”

As an electrical engineering student at Stanford University in the late 1970s, L. Rafael Reif was working on not only his PhD but also learning a new language.

“I didn’t speak English. And I saw that it was easy to ignore somebody who doesn’t speak English well,” Reif recalled. To him, that meant speaking with conviction.

“If you have tremendous technical skills, but you cannot communicate, if you cannot persuade others to embrace that, it’s not going to go anywhere. Without the combination, you cannot persuade the powers-that-be to embrace whatever ideas you have.”

Now MIT president emeritus, Reif recently joined Anantha P. Chandrakasan, chief innovation and strategy officer and dean of the School of Engineering (SoE), for a fireside chat. Their focus: the importance of developing engineering leadership skills — such as persuasive communication — to solve the world’s most challenging problems.

SoE’s Technical Leadership and Communication Programs (TLC) sponsored the chat. TLC teaches engineering leadership, teamwork, and technical communication skills to students, from undergrads to postdocs, through its four programs: Undergraduate Practice Opportunities Program (UPOP), Gordon-MIT Engineering Leadership Program (GEL), Communication Lab (Comm Lab), and Riccio-MIT Graduate Engineering Leadership Program (GradEL).

About 175 students, faculty, and guests attended the fireside chat. Relaxed, engaging, and humorous — Reif shared anecdotes and insights about technical leadership from his decades in leadership roles at MIT.

Reif had a transformational impact on MIT. Beginning as an assistant professor of electrical engineering in 1980, he rose to head of the Department of Electrical Engineering and Computer Science (EECS), then served as provost from 2005 to 2012 and MIT president from 2012 to 2022.

He was instrumental in creating the MIT Schwarzman College of Computing in 2018, as well as establishing and growing MITx online open learning and MIT Microsystems Technology Laboratories.

With an ability to peer over the horizon and anticipate what’s coming, Reif used an array of leadership skills to develop and implement clear visions for those programs.

“One of the things that I learned from you is that as a leader, you have to envision the future and make bets,” said Chandrakasan. “And you don’t just wait around for that. You have to drive it.”

Turning new ideas into reality often meant overcoming resistance. When Reif first proposed the College of Computing to some fellow MIT leaders, “they looked at me and they said, no way. This is too hard. It’s not going to happen. It’s going to take too much money. It’s too complicated. OK, then starts the argument.”

Reif seems to have relished “the argument,” or art of persuasion, during his time at MIT. Though hearing different perspectives never hurt.

“All of us have blind spots. I always try to hear all points of view. Obviously, you can’t integrate all of it. You might say, ‘Anantha, I heard you, but I disagree with you because of this.’ So, you make the call knowing all the options. That is something non-technical that I used in my career.”

On the technical side, Reif’s background as an electrical engineer shaped his approach to leadership.

“What’s beautiful about a technical education is that you understand that you can solve anything if you start with first principles. There are first principles in just about anything that you do. If you start with those, you can solve any problem.”

Also, applying systems-level thinking is critical — understanding that organizations are really systems with interconnected parts.

“That was really useful to me. Some of you in the audience have studied this. In a system, when you start tinkering with something over here, something over there will be affected. And you have to understand that. At a place like MIT, that’s all the time!”

Reif was asked: If he were assembling a dream team to tackle the world’s biggest challenges, what skills or capabilities would he want them to have?

“I think we need people who can see things from different directions. I think we need people who are experts in different disciplines. And I think we need people who are experts in different cultures. Because to solve the big problems of the planet, we need to understand how different cultures address different things.”

Reif’s upbringing in Venezuela strongly influenced his leadership approach, particularly when it comes to empathy, a key trait he values.

“My parents were immigrants. They didn’t have an education, and they had to do whatever they could to support the family. And I remember as a little kid seeing how people humiliated them because they were doing menial jobs. And I remember how painful it was to me. It is part of my fabric to respect every individual, to notice them. I have a tremendous respect for every individual, and for the ability of every individual that didn’t have the same opportunity that all of us here have to be somebody.”

Reif’s advice to students who will be the next generation of engineering leaders is to keep learning because the challenges ahead are multidisciplinary. He also reminded them that they are the future.

“What are our assets? The people in this room. When it comes to the ecosystem of innovation in America, what we work on is to create new roadmaps, expand the roadmaps, create new industries. Without that, we have nothing. Companies do a great job of taking what you come up with and making wonderful things with it. But the ideas, whether it’s AI, whether it’s deep learning, it comes from places like this.” 

Professors Xiao Wang and Rodrigo Verdi, both members of the 2023-25 Committed to Caring cohort, are aiding in the development of extraordinary researchers and contributing to a collaborative culture. 

“Professor Xiao Wang's caring efforts have a profound impact on the lives of her students,” one of her advisees commended.

“Rodrigo's dedication to mentoring and his unwavering support have positively impacted every student in our group,” another student praised.

For MIT graduate students, the Committed to Caring program recognizes those who go above and beyond.

Xiao Wang: Enriching, stimulating, and empowering students

Xiao Wang is a core institute member of the Broad Institute of MIT and Harvard and an associate professor in the Department of Chemistry at MIT. She started her lab in 2019 to develop and apply new chemical, biophysical, and genomic tools to better understand tissue function and dysfunction at the molecular level.

Wang goes above and beyond to create a nurturing environment that fosters growth and supports her students' personal and academic development. She makes it a priority to ensure an intellectually stimulating environment, taking the time to discuss research interests, academic goals, and personal aspirations on a weekly basis. 

In their nominations, her students emphasized that Wang understands the importance of mentorship, patiently explaining fundamental concepts, sharing insights from her own groundbreaking work, and providing her students with key scientific papers and resources to deepen their understanding of the field. 

“Professor Wang encouraged me to think critically, ask challenging questions, and explore innovative approaches to further my research,” one of her students commented.

Beyond the lab, Wang nurtures a sense of community among her research team. Her regular lab meetings are highly valued by her students, where “fellow researchers presented … findings, exchanged ideas, and received constructive feedback.”

These meetings foster collaboration, enhance communication skills, and create a supportive environment where all lab members feel empowered to share their discoveries and insights.

Wang is a dedicated and compassionate educator, and is known for her unwavering commitment to the well-being and success of her students. Her advisees not only excel academically but they also develop resilience, confidence, and a sense of belonging. 

A different student reflected that although they came from an organic chemistry background with few skills related to the chemical biology field, Wang recognized their enthusiasm and potential. She went out of her way to make sure they could have a smooth transition. “It is because of all her training and help that I came from knowing nothing about the field to being able to confidently call myself a chemical biologist,” the student acclaimed.

Her advisees communicate that Wang encourages them to present their work at conferences, workshops, and seminars. This helps boost the students’ confidence and establish connections within the scientific community.

“Her genuine care and dedication make her a cherished mentor and a source of inspiration for all who have the privilege to learn from her,” one of her mentees remarked.

Rodrigo Verdi: Committed and collaborative

Professor Rodrigo Verdi is the deputy dean of degree programs and teaching and learning at the MIT Sloan School of Management. Verdi’s research provides insights into the role of accounting information in corporate finance decisions and in capital markets behavior. 

Professor Verdi has been active in the majority of the Sloan students’ research journeys. He makes sure to assist students even if he does not directly guide them. One student states that “although Rodrigo is not my primary advisor, he still goes above and beyond to provide feedback and assistance.”

Verdi believes that “an appetite for experimentation, the ability to handle failure, and managing the stress along the way” is the kind of support necessary for especially innovative research.

Another student recounts that they “cannot think of a single recent graduate since … [they] started the PhD program that did not have Rodrigo on their committee.” This demonstrates how much students value his guidance, and how much he cares about their success.

Since his arrival at MIT, he has shown a strong commitment to mentoring students. Despite his many responsibilities as an associate dean, Rodrigo remains highly accessible to students and eagerly engages with them. 

Specifically, Verdi has interacted with more than 90 percent of recent graduates over the past 10 years, contributing significantly to the department’s strong track record in job placements. He has served on the dissertation committee for 18 students in the last 15 years, which represents nearly all of the students in the department.

A student remarked that “Rodrigo has been an exceptional advisor during my job market period, which is known for its high levels of stress.” He offered continuous encouragement and support, making himself available for discussions whenever the student faced challenges. 

After each job market interview, Verdi and the student would debrief and discuss areas for improvement. His insights into the academic system, the significance of social skills and networking, and his valuable advice helped the student successfully get a faculty position.

Rodrigo’s mantra is, “people won't care how much you know until they know how much you care,” and his relationships with his students support this maxim.

Verdi has made a lasting impact on the culture of the accounting specialty and is an important piece of the puzzle with regard to interactions found in the Sloan school. One of his students praised, “the collaborative culture is impressive: I’d call it a family, where faculty and students are very close to each other.” They described that they “share the same office space, have lunches together, and whenever students want feedback, the faculty is willing to help.” 

Verdi has sharp research insights, and always wants to help, even when he is swamped with administrative affairs. He makes himself accessible to students, often staying after hours with his door open. 

Another mentee said that “he has been organizing weekly PhD lunch seminars for years, online brown-bags among current and previous MIT accounting members during the pandemic, and more recently the annual MIT accounting alumni conference.” Verdi also takes students out for dinner or coffee, caring about how they are doing outside of academics. The student commended, “I feel lucky that Rodrigo is here.”

Several researchers have taken a broad view of scientific progress over the last 50 years and come to the same troubling conclusion: Scientific productivity is declining. It’s taking more time, more funding, and larger teams to make discoveries that once came faster and cheaper. Although a variety of explanations have been offered for the slowdown, one is that, as research becomes more complex and specialized, scientists must spend more time reviewing publications, designing sophisticated experiments, and analyzing data.

Now, the philanthropically funded research lab FutureHouse is seeking to accelerate scientific research with an AI platform designed to automate many of the critical steps on the path toward scientific progress. The platform is made up of a series of AI agents specialized for tasks including information retrieval, information synthesis, chemical synthesis design, and data analysis.

FutureHouse founders Sam Rodriques PhD ’19 and Andrew White believe that by giving every scientist access to their AI agents, they can break through the biggest bottlenecks in science and help solve some of humanity’s most pressing problems.

“Natural language is the real language of science,” Rodriques says. “Other people are building foundation models for biology, where machine learning models speak the language of DNA or proteins, and that’s powerful. But discoveries aren’t represented in DNA or proteins. The only way we know how to represent discoveries, hypothesize, and reason is with natural language.”

Finding big problems

For his PhD research at MIT, Rodriques sought to understand the inner workings of the brain in the lab of Professor Ed Boyden.

“The entire idea behind FutureHouse was inspired by this impression I got during my PhD at MIT that even if we had all the information we needed to know about how the brain works, we wouldn’t know it because nobody has time to read all the literature,” Rodriques explains. “Even if they could read it all, they wouldn’t be able to assemble it into a comprehensive theory. That was a foundational piece of the FutureHouse puzzle.”

Rodriques wrote about the need for new kinds of large research collaborations as the last chapter of his PhD thesis in 2019, and though he spent some time running a lab at the Francis Crick Institute in London after graduation, he found himself gravitating toward broad problems in science that no single lab could take on.

“I was interested in how to automate or scale up science and what kinds of new organizational structures or technologies would unlock higher scientific productivity,” Rodriques says.

When Chat-GPT 3.5 was released in November 2022, Rodriques saw a path toward more powerful models that could generate scientific insights on their own. Around that time, he also met Andrew White, a computational chemist at the University of Rochester who had been granted early access to Chat-GPT 4. White had built the first large language agent for science, and the researchers joined forces to start FutureHouse.

The founders started out wanting to create distinct AI tools for tasks like literature searches, data analysis, and hypothesis generation. They began with data collection, eventually releasing PaperQA in September 2024, which Rodriques calls the best AI agent in the world for retrieving and summarizing information in scientific literature. Around the same time, they released Has Anyone, a tool that lets scientists determine if anyone has conducted specific experiments or explored specific hypotheses.

“We were just sitting around asking, ‘What are the kinds of questions that we as scientists ask all the time?’” Rodriques recalls.

When FutureHouse officially launched its platform on May 1 of this year, it rebranded some of its tools. Paper QA is now Crow, and Has Anyone is now called Owl. Falcon is an agent capable of compiling and reviewing more sources than Crow. Another new agent, Phoenix, can use specialized tools to help researchers plan chemistry experiments. And Finch is an agent designed to automate data driven discovery in biology.

On May 20, the company demonstrated a multi-agent scientific discovery workflow to automate key steps of the scientific process and identify a new therapeutic candidate for dry age-related macular degeneration (dAMD), a leading cause of irreversible blindness worldwide. In June, FutureHouse released ether0, a 24B open-weights reasoning model for chemistry.

“You really have to think of these agents as part of a larger system,” Rodriques says. “Soon, the literature search agents will be integrated with the data analysis agent, the hypothesis generation agent, an experiment planning agent, and they will all be engineered to work together seamlessly.”

Agents for everyone

Today anyone can access FutureHouse’s agents at platform.futurehouse.org. The company’s platform launch generated excitement in the industry, and stories have started to come in about scientists using the agents to accelerate research.

One of FutureHouse’s scientists used the agents to identify a gene that could be associated with polycystic ovary syndrome and come up with a new treatment hypothesis for the disease. Another researcher at the Lawrence Berkeley National Laboratory used Crow to create an AI assistant capable of searching the PubMed research database for information related to Alzheimer’s disease.

Scientists at another research institution have used the agents to conduct systematic reviews of genes relevant to Parkinson’s disease, finding FutureHouse’s agents performed better than general agents.

Rodriques says scientists who think of the agents less like Google Scholar and more like a smart assistant scientist get the most out of the platform.

“People who are looking for speculation tend to get more mileage out of Chat-GPT o3 deep research, while people who are looking for really faithful literature reviews tend to get more out of our agents,” Rodriques explains.

Rodriques also thinks FutureHouse will soon get to a point where its agents can use the raw data from research papers to test the reproducibility of its results and verify conclusions.

In the longer run, to keep scientific progress marching forward, Rodriques says FutureHouse is working on embedding its agents with tacit knowledge to be able to perform more sophisticated analyses while also giving the agents the ability to use computational tools to explore hypotheses.

“There have been so many advances around foundation models for science and around language models for proteins and DNA, that we now need to give our agents access to those models and all of the other tools people commonly use to do science,” Rodriques says. “Building the infrastructure to allow agents to use more specialized tools for science is going to be critical.”

Ylana Lopez oversees programs and events at the Martin Trust Center for MIT Entrepreneurship. The Trust Center offers more than 60 entrepreneurship and innovation courses across campus, a dedicated entrepreneurship and innovation track for students pursuing their MBA, online courses for self-learners at MIT and around the globe, and programs for people both affiliated and not affiliated with the Institute. As assistant director, academics and events, at the Trust Center, Lopez leads an array of programs and events, while also assisting students and faculty members.

After graduating from Rutgers University, Lopez conducted research in human-computer interaction at Princeton University. After Princeton, she worked for the health care software company Epic Systems, in quality management and user experience. While at Epic Systems, she was simultaneously working on a startup with two of her friends, Kiran Sharma and Dinuri Rupasinghe. One of the startup co-founders, who was an MIT undergraduate student, applied for them to take part in the Trust Center’s flagship startup accelerator delta v, and the trio was accepted.  

Delta v is a highly competitive entrepreneurial program, with 20 to 25 startup teams accepted each year, which runs annually from June to August. At the end of each month, there is a mock board meeting with a board of advisors consisting of industry experts specifically curated to support each startup team’s goals. Programming, coaching sessions, workshops, lectures, and pitch practices take place throughout delta v, and the program culminates in September with a demo day in Kresge Auditorium with thousands of people in attendance.  

Prior to delta v, Lopez decided to leave her full-time job to focus solely on the startup. Once she and her partners went their separate ways, she was looking for a career change, which led her to reflect on her formative summer at MIT. In spring 2023, Lopez applied for an open position at the Trust Center to be an academic coordinator. Soon after, she was offered and accepted the role, and a year later was promoted to assistant director for academics and events. Lopez’s time at MIT has come full circle as her current position includes being a co-director of delta v. Like many of her colleagues who are serial entrepreneurs, Lopez has also started a design studio on the side in the past year called Mr. Mango, providing creative design services for film and music industries.

Lopez has always loved education and planned to become a teacher before deciding to enter the field of technology. Because of this, she describes working at MIT, and being a staff member in the Trust Center, as having the best of both worlds. While delta v is the flagship accelerator, Lopez also supports shorter programs including MIT Fuse, a three-week, hands-on startup sprint that takes place during Independent Activities Period (IAP), and t=0, a festival of events that kicks off each school year to promote entrepreneurship at MIT. In addition to delta v, other programs are available to those outside of MIT, as the Trust Center sees the value of bringing together an ecosystem that is not solely composed of those at the Institute.

At the core of the Trust Center is the belief that entrepreneurship is a tool to change the world. The staff also believe entrepreneurship can be taught, and is not just for a select few. Lopez and her colleagues are highly collaborative and work in an office space that they affectionately call “the bullpen.” The office layout and shared nature of their work mean that no one is a stranger. With at least two events per week, late nights can turn into early mornings, but Lopez and her colleagues love what they do. She is grateful for the growth she has had in her time at the Trust Center and the opportunity to be a part of a motivated, fun, and talented team.

Trust Center managing director Bill Aulet, the Ethernet Inventors Professor of the Practice of Entrepreneurship, cannot sing Lopez’s praises enough. “In my now almost two decades running this center, I have never seen anyone better at really understanding the students, our customers, and translating that back into high-quality and creative programs that delight them and serve the mission of our center, MIT Sloan, and MIT more broadly. We are so fortunate to have her.”

Soundbytes

Q: What is your favorite project that you have worked on?

A: This semester we piloted the Martin Trust Center Startup Pass. It is an opportunity for startups, regardless of what stage they are in, to have a daily, dedicated workspace at the Trust Center to make progress on their ventures. We set aside half of our space for what we call “the beehive” for startups to work alongside other founders and active builders at MIT. It’s great for students to sit alongside people who are building awesome things and will provide feedback, offer support, and really build a community that is entirely based off the spirit and collaboration that naturally comes to entrepreneurs. Entrepreneurship can be lonely; therefore, a lot of our efforts go toward helping build networks that make it less so. In just one semester, we’ve already created a community of over 80 founders across MIT!

I’m also excited about revamping one of our rooms into a creative studio. We noticed that startups could benefit from having a space that has capabilities for creating content like podcasts, photography, videography, and other types of creative work. Those things are important in entrepreneurship, so we are currently cultivating a space that any entrepreneur at MIT can utilize.

Q: How would you describe the MIT community?

A: We have such a wonderful community here. The Trust Center supports all of MIT, so we have many programs that allow us to see a lot of people. There can be silos, so it’s great that we bring people together, regardless of their backgrounds, experience, or interests, in one place to become entrepreneurs. The MIT community is a group of inspiring, passionate people who are very welcoming. It’s a very exciting community to be a part of.

Q: What advice would you give someone who is starting a job at MIT?

A: If your day-to-day is typically in one office or setting, over time it can be easy to find yourself in a bubble. I highly recommend breaking out of your bubble by making the effort to meet as many people outside of the group that you work with directly as possible. I have met a number of people across different departments, even if we don’t have much direct overlap in terms of work, and they have been incredibly helpful, gracious, and welcoming. You never know if an introductory or impromptu conversation with someone might lead to an awesome collaboration or new initiative. It’s great being in a community with so many talented people. 

Leveraging the strengths of two world-class research institutions, MIT and Mass General Brigham (MGB) recently celebrated the launch of the MIT-MGB Seed Program. The new initiative, which is supported by Analog Devices Inc. (ADI), will fund joint research projects led by researchers at MIT and Mass General Brigham. These collaborative projects will advance research in human health, with the goal of developing next-generation therapies, diagnostics, and digital tools that can improve lives at scale. 

The program represents a unique opportunity to dramatically accelerate innovations that address some of the most urgent challenges in human health. By supporting interdisciplinary teams from MIT and Mass General Brigham, including both researchers and clinicians, the seed program will foster groundbreaking work that brings together expertise in artificial intelligence, machine learning, and measurement and sensing technologies with pioneering clinical research and patient care.

“The power of this program is that it combines MIT’s strength in science, engineering, and innovation with Mass General Brigham’s world-class scientific and clinical research. With the support and incentive to work together, researchers and clinicians will have the freedom to tackle compelling problems and find novel ways to overcome them to achieve transformative changes in patient care,” says Sally Kornbluth, president of MIT.

“The MIT-MGB Seed Program will enable cross-disciplinary collaboration to advance transformative research and breakthrough science. By combining the collective strengths and expertise of our great institutions, we can transform medical care and drive innovation and discovery with speed,” says Anne Klibanski, president and CEO of Mass General Brigham.

The initiative is funded by a gift from ADI. Over the next three years, the ADI Fund for Health and Life Sciences will support approximately six joint projects annually, with funding split between the two institutions. 

“The converging domains of biology, medicine, and computing promise a new era of health-care efficacy, efficiency, and access. ADI has enjoyed a long and fruitful history of collaboration with MIT and Mass General Brigham, and we are excited by this new initiative’s potential to transform the future of patient care,” adds Vincent Roche, CEO and chair of the board of directors at ADI.

In addition to funding, teams selected for the program will have access to entrepreneurial workshops, including some hosted by The Engine — an MIT-built venture firm focused on tough tech. These sessions will connect researchers with company founders, investors, and industry leaders, helping them chart a path from breakthrough discoveries in the lab to real-world impact.

The program will launch an open call for proposals to researchers at MIT and Mass General Brigham. The first cohort of funded projects is expected to launch in fall 2025. Awardees will be selected by a joint review committee composed of MIT and Mass General Brigham experts.

According to MIT’s faculty lead for the MIT-MGB Seed Program, Alex K. Shalek, building collaborative research teams with leaders from both institutions could help fill critical gaps that often impede innovation in health and life sciences. Shalek also serves as director of the Institute for Medical Engineering & Science (IMES), the J. W. Kieckhefer Professor in IMES and Chemistry, and an extramural member of the Koch Institute for Integrative Cancer Research.

 “Clinicians often see where current interventions fall short, but may lack the scientific tools or engineering expertise needed to develop new ones. Conversely, MIT researchers may not fully grasp these clinical challenges or have access to the right patient data and samples,” explains Shalek, who is also a member of the Ragon Institute of Mass General Brigham, MIT, and Harvard. “By supporting bilateral collaborations and building a community across disciplines, this program is poised to drive critical advances in diagnostics, therapeutics, and AI-driven health applications.”

Emery Brown, a practicing anesthesiologist at Massachusetts General Hospital, will serve alongside Shalek as Mass General Brigham’s faculty lead for the program.

“The MIT-MGB Seed Program creates a perfect storm. The program will provide an opportunity for MIT faculty to bring novel science and engineering to attack and solve important clinical problems,” adds Brown, who is also the Edward Hood Taplin Professor of Medical Engineering and Computational Neuroscience at MIT. “The pursuit of solutions to important and challenging clinical problems by Mass General Brigham physicians and scientists will no doubt spur MIT scientists and engineers to develop new technologies, or find novel applications of existing technologies.”

The MIT-MGB Seed Program is a flagship initiative in the MIT Health and Life Sciences Collaborative (MIT HEALS). It reflects MIT HEALS’ core mission to establish MIT as a central hub for health and life sciences innovation and translation, and to leverage connections with other world-class research institutions in the Boston area.

“This program exemplifies the power of interdisciplinary research,” says Anantha Chandrakasan, MIT’s chief innovation and strategy officer, dean of engineering, and head of MIT HEALS. “It creates a critical bridge between clinical practice and technological innovation — two areas that must be deeply connected to advance real-world solutions.”

The program’s launch was celebrated at a special event at MIT’s Samberg Conference Center on March 31.

Diffusion models like OpenAI’s DALL-E are becoming increasingly useful in helping brainstorm new designs. Humans can prompt these systems to generate an image, create a video, or refine a blueprint, and come back with ideas they hadn’t considered before.

But did you know that generative artificial intelligence (GenAI) models are also making headway in creating working robots? Recent diffusion-based approaches have generated structures and the systems that control them from scratch. With or without a user’s input, these models can make new designs and then evaluate them in simulation before they’re fabricated.

A new approach from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) applies this generative know-how toward improving humans’ robotic designs. Users can draft a 3D model of a robot and specify which parts they’d like to see a diffusion model modify, providing its dimensions beforehand. GenAI then brainstorms the optimal shape for these areas and tests its ideas in simulation. When the system finds the right design, you can save and then fabricate a working, real-world robot with a 3D printer, without requiring additional tweaks.

The researchers used this approach to create a robot that leaps up an average of roughly 2 feet, or 41 percent higher than a similar machine they created on their own. The machines are nearly identical in appearance: They’re both made of a type of plastic called polylactic acid, and while they initially appear flat, they spring up into a diamond shape when a motor pulls on the cord attached to them. So what exactly did AI do differently?

A closer look reveals that the AI-generated linkages are curved, and resemble thick drumsticks (the musical instrument drummers use), whereas the standard robot’s connecting parts are straight and rectangular.

Better and better blobs

The researchers began to refine their jumping robot by sampling 500 potential designs using an initial embedding vector — a numerical representation that captures high-level features to guide the designs generated by the AI model. From these, they selected the top 12 options based on performance in simulation and used them to optimize the embedding vector.

This process was repeated five times, progressively guiding the AI model to generate better designs. The resulting design resembled a blob, so the researchers prompted their system to scale the draft to fit their 3D model. They then fabricated the shape, finding that it indeed improved the robot’s jumping abilities.

The advantage of using diffusion models for this task, according to co-lead author and CSAIL postdoc Byungchul Kim, is that they can find unconventional solutions to refine robots.

“We wanted to make our machine jump higher, so we figured we could just make the links connecting its parts as thin as possible to make them light,” says Kim. “However, such a thin structure can easily break if we just use 3D printed material. Our diffusion model came up with a better idea by suggesting a unique shape that allowed the robot to store more energy before it jumped, without making the links too thin. This creativity helped us learn about the machine’s underlying physics.”

The team then tasked their system with drafting an optimized foot to ensure it landed safely. They repeated the optimization process, eventually choosing the best-performing design to attach to the bottom of their machine. Kim and his colleagues found that their AI-designed machine fell far less often than its baseline, to the tune of an 84 percent improvement.

The diffusion model’s ability to upgrade a robot’s jumping and landing skills suggests it could be useful in enhancing how other machines are designed. For example, a company working on manufacturing or household robots could use a similar approach to improve their prototypes, saving engineers time normally reserved for iterating on those changes.

The balance behind the bounce

To create a robot that could jump high and land stably, the researchers recognized that they needed to strike a balance between both goals. They represented both jumping height and landing success rate as numerical data, and then trained their system to find a sweet spot between both embedding vectors that could help build an optimal 3D structure.

The researchers note that while this AI-assisted robot outperformed its human-designed counterpart, it could soon reach even greater new heights. This iteration involved using materials that were compatible with a 3D printer, but future versions would jump even higher with lighter materials.

Co-lead author and MIT CSAIL PhD student Tsun-Hsuan “Johnson” Wang says the project is a jumping-off point for new robotics designs that generative AI could help with.

“We want to branch out to more flexible goals,” says Wang. “Imagine using natural language to guide a diffusion model to draft a robot that can pick up a mug, or operate an electric drill.”

Kim says that a diffusion model could also help to generate articulation and ideate on how parts connect, potentially improving how high the robot would jump. The team is also exploring the possibility of adding more motors to control which direction the machine jumps and perhaps improve its landing stability.

The researchers’ work was supported, in part, by the National Science Foundation’s Emerging Frontiers in Research and Innovation program, the Singapore-MIT Alliance for Research and Technology’s Mens, Manus and Machina program, and the Gwangju Institute of Science and Technology (GIST)-CSAIL Collaboration. They presented their work at the 2025 International Conference on Robotics and Automation.

Much like Middle Eastern oil production in the 1970s, China today dominates the global refinement of critical metals that serve as the foundation of the United States economy. In the 1970s, America’s oil dependence led to shortages that slowed growth and brought huge spikes in prices. But in recent decades, U.S. fracking technology created a new way to extract oil, transforming the nation from one of the world’s largest oil importers to one of the largest exporters.

Today the U.S. needs another technological breakthrough to secure domestic supplies of metals like lithium, cobalt, copper, and rare earth elements, which are needed for everything from batteries to jet engines and electric motors. Nth Cycle thinks it has a solution.

The company was co-founded by MIT Associate Professor Desirée Plata, CEO Megan O’Connor, and Chief Scientist Chad Vecitis to recover critical metals from industrial waste and ores using a patented, highly efficient technology known as electro-extraction.

“America is an incredibly resource-rich nation — it’s just a matter of extracting and converting those resources for use. That’s the role of refining,” says O’Connor, who worked on electro-extraction as a PhD student with Plata, back when both were at Duke University. “By filling that gap in the supply chain, we can make the United States the largest producer of critical metals in the world.”

Since last year, Nth Cycle has been producing cobalt and nickel using its first commercial system in Fairfield, Ohio. The company’s modular refining systems, which are powered by electricity instead of fossil fuels, can be deployed in a fraction of the time of traditional metal refining plants. Now, Nth Cycle aims to deploy its modular systems around the U.S. and Europe to establish new supply chains for the materials that power our economy.

“About 85 percent of the world’s critical minerals are refined in China, so it’s an economic and national security issue for us,” O’Connor says. “Even if we mine the materials here — we do have one operational nickel mine in Michigan — we then ship it overseas to be refined. Those materials are required components of multiple industries. Everything from our phones to our cars to our defense systems depend on them. I like to say critical minerals are the new oil.”

From waste, an opportunity

In 2014, O’Connor and Plata attended a talk by Vecitis, then a professor at Harvard University, in which he discussed his work using electrochemical filters to destroy contaminants in pharmaceutical wastewater. As part of the research, he noticed the material was reacting with metal to create crystalline copper in the filters. Following the talk, Plata asked Vecitis if he’d ever thought about using the approach for metal separation. He hadn’t but was excited to try.

At the time, Plata and O’Connor were studying mineral-dense wastewater created as a byproduct of hydraulic fracturing for oil and gas.

“The original thought was: Could we use this technology to extract those metals?” O’Connor recalls.

The focus shifted to using the technology to recover metals from electronics waste, including sources like old phones, electric vehicles, and smartwatches.

Today, manufacturers and electronic waste facilities grind up end-of-life materials and send it to huge chemical refineries overseas, which heat up the metal into a molten liquid and put it through a series of acids and bases to distill the waste back into a pure form of the desired metal.

“Each of those acids and bases have to be transported as hazardous goods, and the process for making them has a large greenhouse gas and energy footprint,” Plata explains. “That makes the economics difficult to square in anything but huge, centralized facilities — and even then it’s a challenge.”

The United States and Europe have an abundance of end-of-life scrap material, but it’s dispersed, and environmental regulations have left the West few scalable refining options.

Instead of building a refinery, Nth Cycle’s team has built a modular refining system — dubbed “The Oyster” — which can reduce costs, waste, and time-to-market by being co-located onsite with recyclers, miners, and manufacturers. The Oyster uses electricity, chemical precipitation, and filtration to create the same metal refining chemicals as traditional methods. Today, the system can process more than 3,000 metric tons of scrap per year and be customized to produce different metals.

“Electro-extraction is one of the cleanest ways to recover metal,” Plata says.

Nth Cycle received early support from the U.S. Department of Energy, and when Plata came to MIT in 2018, Nth Cycle became part of the MIT Industrial Liaison Program’s STEX25 startup accelerator.

“What’s so important about being at a place like MIT is the entrepreneurial ecosystem and the ‘tough tech’ ethos of Cambridge,” Plata explains. “That’s been hugely important to the success of Nth Cycle and one of the reasons we moved the company to the greater Boston area. Being able to access talent and patient capital was key.”

Onshoring metal refining

Plata says one of the proudest moments of her career came last year at the groundbreaking ceremony for Nth Cycle’s first mixed hydroxide (nickel and cobalt) production facility in Ohio. Many of Nth Cycle’s new employees at the facility had previously worked at auto and chemical facilities in the town but are now working for what Nth Cycle calls the first commercial nickel refining facility for scrap in the country.

“O’Connor’s vision of elevating people while elevating the economy is an inspiring standard of practice,” Plata says.

Nth Cycle will own and operate other Oyster systems in a business model O’Connor describes as refining as a service, where customers own the final product. The company is looking to partner with scrap yards and industrial scrap collection facilities as well as manufacturers that generate waste.

Nth Cycle is mostly working to recover metals from batteries today, but it has also used its process to recover cobalt and nickel from spent catalyst material in the oil and gas industry. Moving forward, Nth Cycle hopes to apply its process to the biggest waste sources of them all: mining.

“The world needs more critical minerals like cobalt, nickel, lithium, and copper,” O’Connor says. “The only two places you can get those materials are from recycling and mining, and both of those sources need to be chemically refined. That’s where Nth Cycle comes in. A lot of people have a negative perception of mining, but if you have a technology that can reduce waste and reduce emissions, that’s how you get more mining in regions like the U.S. That’s the impact we want this technology to have in the Western world.”

Es Devlin, the winner of the 2025 Eugene McDermott Award in the Arts at MIT, creates settings for people to gather — whether it’s a few people in a room or crowds swelling a massive stadium — arenas in which to dissolve one’s individual sense of self into the greater collective. She herself contains multitudes; equally at home with 17th century metaphysical English poet John Donne, 21st century icon of music and fashion Lady Gaga, or Italian theoretical physicist Carlo Rovelli.

In the course of the artist and designer’s three-decade career, Devlin has created an exploded paint interpretation of the U.K. flag for the Closing Ceremony of the 2012 London Olympics, a box of illuminated rainfall for a production of the Crucible, a 65-foot diameter AI-generated poetry pavilion for the World Expo, an indoor forest for the COP26 Climate Conference, a revolving luminous library for over 200,000 in Milan, Beyonce’s Renaissance tour, and two Super Bowl halftime shows. But Devlin also works on a much smaller scale: the human face. Her world-building is rooted in the earliest technologies of reading and drawing: the simple acts of the eye and hand.  

For Congregation in 2024, she made chalk and charcoal drawings of 50 strangers. Before this project, Devlin says, she had most likely drawn around 50 portraits in total over the course of her practice — mostly family or friends, or the occasional covert sketch of a stranger on the subway. But drawing strangers required a different form of attention. “I was looking at another, who often looked different from me in many ways. Their skin pigmentation might be different, the orientation of their nose, eyes, and forehead might be other to what I was used to seeing in the mirror, and I was fraught with anxiety and concern to do them justice, and at pains not to offend,” she recalls. 

As she drew, she warded off the desire to please, feeling her unconscious biases surface, but eventually, in this wordless space, found herself in intense communion. “I gradually became absorbed in each person's eyes. It felt like falling into a well, but knowing I was held by an anchor, that I would be drawn out,” she says, “In each case, I thought, ‘well, this is it. Here we are. This is the answer to everything, the continuity between me and the other.’” She calls each sitter a co-creator of the piece. 

Devlin’s project inspired a series of drawing sessions at MIT, where students, faculty, and staff across the Institute — without any prior drawing experience necessary — were paired with strangers and asked to draw each other in silence for five minutes. In these 11 sessions held over the course of the semester, participants practiced rendering a stranger’s features on the page, and then the sitter spoke and shared their story. There were no guidelines about what to say, or even how to draw — but the final product mattered less than the process, the act of being in another’s presence and looking deeply. 

If pop concerts are the technology to transform private emotional truth into public feeling — the lyrics sung to the bathroom mirror now belted in choruses of thousands — Devlin finds that same stripped-down intimacy in all her works, asking us to bare the most elemental versions of ourselves. 

“We’re in a moment where we’re really having a hard time speaking to one another. We wanted to find a way to take the lessons from the work that Es Devlin has done to practice listening to one another and building connections within this very broad community that we call MIT,” says Sara Brown, an associate professor in the Music and Theater Arts Section who facilitated drawing sessions. The drawings were then displayed in a pop-up group exhibition, MIT Face to Face, where 80 easels were positioned to face the center of the room like a two-dimensional choir, forming a communal portrait of MIT. 

During her residency at MIT, Devlin toured student labs, spoke with students and faculty from theater arts, discussed the creative uses of AI with technologists and curators, and met with neuroscientists. “I had my brain scanned two days ago at very short notice,” she says, “a functioning MRI scan to help me understand more deeply the geography and architecture of my own mind.”  

“The question I get asked most is, ‘How do you retain a sense of self when you are in collaboration with another, especially if it’s another who is celebrated and widely revered?’” she says, “And I found an answer to that question: You have to be prepared to lose yourself. You have to be prepared to sublimate your sense of self, to see through the eyes of another, and through that practice, you will begin to find more deeply who you are.”

She is influenced by the work of philosopher and neuroscientist Iain Gilchrist, who suggests that a society dominated by the mode of attention of the left hemisphere — the part of the brain broadly in charge of language processing and logical thinking — also needs to be balanced by the right hemisphere, which operates nonverbal modes of attention. While the left hemisphere categorizes and separates, the right attends to the universe as an oceanic whole. And it is under the power of the right hemisphere’s mode of attention, Devlin says, that she enters the flow state of drawing, a place outside the confines of language, that enables her to feel a greater sense of unity with the entire cosmos.

Whether it’s drawing a stranger with a pencil and paper, or working with collaborators, Devlin believes the key to self understanding is, paradoxically, losing oneself.

In all her works, she seeks the ecstatic moment when the boundaries between self and world become more porous. In a time of divisiveness, her message is important. “I think it’s really to do with fear of other,” she says, “and I believe that dislodging fear is something that has to be practiced, like learning a new instrument.” What would it be like to regain a greater equilibrium between the modes of attention of both hemispheres of the brain, the sense of distinctness and the cosmic whole at once? “It could be absolutely definitive, and potentially stave off human extinction,” she says, “It’s at that level of urgency.”  

Presented by the Council for the Arts at MIT, the Eugene McDermott Award for the Arts at MIT was first established by Margaret McDermott in honor of her husband, a legacy that is now carried on by their daughter, Mary McDermott Cook. The Eugene McDermott Award plays a unique role at the Institute by bringing the MIT community together to support MIT’s principal arts organizations: the Department of Architecture; the Program in Art, Culture and Technology; the Center for Art, Science and Technology; the List Visual Arts Center; the MIT Museum; and Music and Theater Arts. During her residency at MIT she presented a week of discussions with the MIT community’s students and faculty in theater, architecture, computer science, MIT Museum Studio, and more. She also presented a public artist talk with Museum of Modern Art Senior Curator of Architecture and Design Paola Antonelli that was one of the culminating events of the MIT arts festival, Artfinity. 

Summer is the perfect time to curl up with a good book — and MIT authors have had much to offer in the past year. The following titles represent some of the books published in the past 12 months by MIT faculty and staff. In addition to links for each book from its publisher, the MIT Libraries has compiled a helpful list of the titles held in its collections.

Looking for more literary works from the MIT community? Enjoy our book lists from 2024, 2023, 2022, and 2021.

Happy reading!

Science

“So Very Small: How Humans Discovered the Microcosmos, Defeated Germs — and May Still Lose the War Against Infectious Disease” (Penguin Random House, 2025)
By Thomas Levenson, professor of science writing

For centuries, people in the West, believing themselves to hold God-given dominion over nature, thought too much of humanity and too little of microbes. Nineteenth-century scientists finally made the connection. Life-saving methods to control infections and contain outbreaks soon followed. Next came the antibiotic era in the 1930s. Yet, less than a century later, the promise of that revolution is receding due to years of overuse. Is our self-confidence getting the better of us again?

“The Miraculous from the Material: Understanding the Wonders of Nature” (Penguin Random House, 2024)
By Alan Lightman, professor of the practice of humanities

Nature is capable of extraordinary phenomena. Standing in awe of those phenomena, we experience a feeling of connection to the cosmos. For Lightman, just as remarkable is that all of what we see around us — soap bubbles, scarlet ibises, shooting stars — are made out of the same material stuff and obey the same rules and laws. Pairing 36 full-color photos evoking some of nature’s most awe-inspiring phenomena with personal essays, “The Miraculous from the Material” explores the fascinating science underlying the natural world.

Technology and society

“The Analytics Edge in Healthcare” (Dynamic Ideas, 2025)
By Dimitris Bertsimas, vice provost for MIT Open Learning, Boeing Leaders for Global Operations Professor of Management, associate dean for business analytics, and professor of operations research; Agni Orfanoudaki, and Holly Wiberg

Analytics is transforming health care operations, empowering medical professionals and administrators to leverage data and models to make better decisions. This book provides a practical introduction to this exciting field. The first part establishes the technical foundations of health care analytics, spanning machine learning and optimization. The second part presents integrated case studies that cover a wide range of clinical specialties and problem types using descriptive, predictive, and prescriptive analytics.

“Longevity Hubs: Regional Innovation for Global Aging”  (MIT Press, 2024)
Edited by Joseph F. Coughlin, senior research scientist and MIT AgeLab director, and Luke Yoquinto, MIT AgeLab research associate 

Populations around the world are aging, and older adults’ economic influence stands to grow markedly in future decades. This volume brings together entrepreneurs, researchers, designers, public servants, and others to address the multifaceted concerns of aging societies and to explore the possibility that certain regions will distinguish themselves as longevity hubs: home to disproportionate economic and innovative activity for older populations.

“Data, Systems, and Society: Harnessing AI for Societal Good” (Cambridge University Press, 2025)
By Munther Dahleh, the William A. Coolidge Professor of Electrical Engineering and Computer Science and director of the Institute for Data, Systems, and Society (IDSS)

Harnessing the power of data and artificial intelligence (Al) methods to tackle complex societal challenges requires transdisciplinary collaborations across academia, industry, and government. In this book, Dahleh, founder of the MIT Institute for Data, Systems, and Society (IDSS), offers a blueprint for researchers, professionals, and institutions to create approaches to problems of high societal value using innovative, holistic, data-driven methods.

“SuperShifts: Transforming How We Live, Learn, and Work in the Age of Intelligence” (Wiley, 2025)
By Ja-Naé Duane, academic research fellow at the MIT Center for Information Systems Research, and Steve Fisher

This book describes how we’re at the end of one 200-year arc and embarking on another. With this new age of intelligence, Duane and Fisher highlight the catalysts for change currently affecting individuals, businesses, and society as a whole. They also provide a model for transformation that utilizes a holistic view of making radical change through three lenses: you as a leader, your organization, and society.

“Tech Agnostic: How Technology Became the World’s Most Powerful Religion, and Why It Desperately Needs a Reformation” (MIT Press, 2024)
By Greg Epstein, humanist chaplain

Today’s technology has overtaken religion as the chief influence on 21st-century life and community. In “Tech Agnostic,” Epstein explores what it means to be a critical thinker with respect to this new faith. Encouraging readers to reassert their common humanity beyond the seductive sheen of “tech,” this book argues for tech agnosticism — not worship — as a way of life.

“The New Lunar Society: An Enlightenment Guide to the Next Industrial Revolution” (MIT Press, 2025)
By David Mindell, the Dibner Professor of the History of Engineering and Manufacturing and professor of aeronautics and astronautics 

Climate change, global disruption, and labor scarcity are forcing us to rethink the underlying principles of industrial society. In this book, Mindell envisions this new industrialism from the fundamentals, drawing on the 18th century when first principles were formed at the founding of the Industrial Revolution. While outlining the new industrialism, he tells the story of the Lunar Society, a group of engineers, scientists, and industrialists who came together to apply the principles of the Enlightenment to industrial processes.

“Output: An Anthology of Computer-Generated Text, 1953–2023” (MIT Press, 2024) 
Edited by Nick Montfort, professor of digital media, and Lillian-Yvonne Bertram

The discussion of computer-generated text has recently reached a fever pitch but largely omits the long history of work in this area — text generation, as it happens, was not invented yesterday in Silicon Valley. This anthology aims to correct that omission by gathering seven decades of English-language texts produced by generation systems and software, long before ChatGPT and Claude.

Education, work, and innovation

“Retiring: Creating a Life That Works for You” (Routledge, 2025)
By Lotte Bailyn, the T Wilson Professor of Management, Emerita and professor emerita of work and organization studies; Teresa M. Amabile; Marcy Crary; Douglas T. Hall; and Kathy E. Kram

Whether they’re one of the 73 million baby boomers reaching their full retirement benefit age or zoomers just entering the workforce, at some point most working Americans will retire. The optimal approach to retirement is unique to each person, but this book offers wisdom and anecdotes from more than 120 people and detailed interviews with 14 “stars” regarding their retirement transitions.

“Accelerating Innovation: Competitive Advantage through Ecosystem Engagement” (MIT Press, 2025)
By Phil Budden, senior lecturer of technological Innovation, entrepreneurship, and strategic management; and Fiona Murray, associate dean for innovation, the William Porter Professor of Entrepreneurship, and professor of technological innovation, entrepreneurship, and strategic management 

Leaders in large organizations face continuous pressure to innovate, and few possess the internal resources needed to keep up with rapid advances in science and technology. But looking beyond their own organizations, most face a bewildering landscape of external resources. In “Accelerating Innovation,” leaders will find a practical guide to this external landscape. Budden and Murray provide directions for navigating innovation ecosystems — those hotspots worldwide where researchers, entrepreneurs, and investors congregate.

“Writing, Thinking, and the Brain: How Neuroscience Can Improve Writing Instruction” (Teachers College Press, 2024)
By Joel R. S. Nazareno, learning science and education outreach specialist at MIT Open Learning; Tracey Tokuhama-Espinosa; and Christopher Rappleye

Writing is the highest form of thinking, as evidenced by neuroimaging that shows how more neural networks are activated simultaneously during writing than during any other cognitive activity. This book will help teachers understand how the brain learns to write by unveiling 15 stages of thinking that underpin the writing process, along with targeted ways to stimulate them to maximize each individual’s writing potential.

“Entrepreneurship: Choice and Strategy” (Norton Economics, 2024)
By Erin L. Scott, senior lecturer of technological innovation, entrepreneurship, and strategic management; Scott Stern, the David Sarnoff Professor of Management of Technology and professor of technological innovation, entrepreneurship, and strategic management; and Joshua Gans

Building on more than two decades of academic research with thousands of companies and MIT students, Scott, Stern, and Gans have developed a systematic approach for startup leadership. They detail four key choices entrepreneurs must make, and “four strategic approaches to find and frame opportunities.”

“Failure by Design: The California Energy Crisis and the Limits of Market Planning” (University of Chicago, 2024)
By Georg Rilinger, the Fred Kayne Career Development Assistant Professor of Entrepreneurship and assistant professor of technological innovation, entrepreneurship, and strategic management

The California electricity crisis in 2000 caused billions in losses and led to bankruptcy for one of the state’s largest utilities. More than 20 years later, the question remains: Why did the newly created electricity markets fail? In “Failure by Design,” Rilinger explores practical obstacles to market design to offer a new explanation for the crisis — one that moves beyond previous interpretations that have primarily blamed incompetent politicians or corrupt energy sellers.

Culture, humanities, and social sciences

“Chasing the Pearl-Manuscript: Speculation, Shapes, Delight” (University of Chicago Press, 2025)
By Arthur Bahr, professor of literature

In this book, Bahr explores the four poems and 12 illustrations of the “Pearl-Manuscript,” the only surviving medieval copy of two of the best-known Middle English poems: “Pearl” and “Sir Gawain and the Green Knight.” He explores how the physical manuscript enhances our perception of the poetry, drawing on recent technological advances that show it to be a more complex piece of material, visual, and textual art than previously understood. By connecting the manuscript’s construction to the text’s intricate language, Bahr suggests new ways to understand the power of poetry.

“Taxation and Resentment: Race, Party, and Class in American Tax Attitudes” (Princeton University Press, 2025)
By Andrea Campbell, the Arthur and Ruth Sloan Professor of Political Science

Most Americans want the rich to pay more to fund government, yet favor regressive over progressive taxes. Why this policy-preference gap? In this book, Campbell describes how convoluted tax code confuses the public about who pays and who benefits, so tax preferences do not turn on principles, interests, or even party. Instead, race and racism play large roles, and tax skepticism among Americans of all stripes helps the rich and anti-tax forces undermine progressivity.

“Uprooted: How post-WWII Population Transfers Remade Europe” (Cambridge University Press, 2024)
By Volha Charnysh, the Ford Career Development Associate Professor of Political Science

Each year, millions of people are uprooted from their homes by wars, repression, natural disasters, and climate change. In “Uprooted,” Charnysh presents a fresh perspective on the consequences of mass displacement, arguing that accommodating the displaced population can strengthen receiving states and benefit local economies. With rich insights and compelling evidence, the book challenges common assumptions about the costs of forced displacement and cultural diversity and proposes a novel mechanism linking wars to state-building.

“Crime, Insecurity, and Community Policing: Experiments on Building Trust” (Cambridge University Press, 2024)
By Fotini Christia, the Ford International Professor of the Social Sciences; Graeme Blair; and Jeremy M. Weinstein

How can societies reduce crime without exacerbating adversarial relationships between the police and citizens? Through field experiments in a variety of political contexts, this book presents the outcome of a major research initiative into the efficacy of community policing. Scholars uncover whether, and under what conditions, this influential strategy for tackling crime and insecurity is effective. With its highly innovative approach to cumulative learning, this writing represents a new frontier in the study of police reform.

“Letterlocking: The Hidden History of the Letter” (MIT Press, 2025)
By Jana Dambrogio, the Thomas F. Peterson Conservator at MIT Libraries, and Daniel Starza Smith 

Before the invention of the gummed envelope in the 1830s, how did people secure their private letters? The answer is letterlocking — the ingenious process of securing a letter using a combination of folds, tucks, slits, or adhesives such as sealing wax, so that it becomes its own envelope. In this book, Dambrogio and Starza Smith, experts who have pioneered the field over the last 10 years, tell the fascinating story of letterlocking within epistolary history, drawing on real historical examples from all over the world.

“Long-Term Care around the World” (University of Chicago Press, 2025)
Edited by Jonathan Gruber, the Ford Professor of Economics and head of the Department of Economics, and Kathleen McGarry

As formal long-term care becomes unaffordable for seniors in many countries, public systems and unpaid caregivers increasingly bear the burden of supporting the world’s aging population. “Long-Term Care around the World” is a comparative analysis of long-term care in 10 wealthy countries that considers the social costs of both formal and informal care  —which is critical, given that informal unpaid care is estimated to account for one-third of all long-term care spending.

“Empty Vessel: The Global Economy in One Barge” (Penguin Random House, 2025)
By Ian Kumekawa, lecturer of history

What do a barracks for British troops in the Falklands War, a floating jail off the Bronx, and temporary housing for VW factory workers in Germany have in common? The Balder Scapa: a single barge that served all three roles. Through this one vessel, Kumekawa illustrates many currents: globalization, the transience of economic activity, and the hazy world of transactions many call “the offshore,” the lightly regulated sphere of economic activity that encourages short-term actions.

“The Price of Our Values: The Economic Limits of Moral Life” (University of Chicago Press, 2025)
By David Thesmar, the Franco Modigliani Professor of Financial Economics and professor of finance, and Augustin Landier

Two economists examine the interplay between our desire to be good, the personal costs of being good, and the point at which people abandon goodness due to its costs. Aided by the results of two surveys, they find that the answers to modern moral dilemmas are economic, and often highly predictable. Our values may guide us, but we are also forced to consider economic costs to settle decisions.

“Spheres of Injustice: The Ethical Promise of Minority Presence” (MIT Press, 2025)
By Bruno Perreau, the Cynthia L. Reed Professor of French Studies 

How can the rights of minorities be protected in democracies? The question has been front and center in the U.S. since the Supreme Court’s repeal of affirmative action. In Europe too, minority politics are being challenged. The very notion of “minority” is being questioned, while the notion of a “protected class” risks encouraging competition among minorities. In “Spheres of Injustice,” Perreau demonstrates how we can make the fight against discrimination beneficial for all.

“Attention, Shoppers! American Retail Capitalism and the Origins of the Amazon Economy” (Princeton University Press, 2025)
By Kathleen Thelen, the Ford Professor of Political Science

This book traces the evolution of U.S. retailing from the late 19th century to today, uncovering the roots of a bitter equilibrium where large low-cost retailers dominate and vast numbers of low-income families now rely on them to make ends meet. Thelen reveals how large discount retailers have successfully exploited a uniquely permissive regulatory landscape to create a shopper’s paradise built on cheap labor.

“Routledge Handbook of Space Policy” (Routledge, 2024)
Chapter by Danielle R. Wood, associate professor in the program in media arts and sciences and associate professor in aeronautics and astronautics

In her chapter, “The Expanding Sphere of Human Responsibility for Sustainability on Earth and in Space,” Wood proposes a multifaceted definition of sustainability and explores how the definition can be exercised as humans expand activity in space. Building on the tradition of consensus building on concepts of sustainable development through United Nations initiatives, Wood asserts that sustainability for human activity in space requires consideration of three types of responsibility: economic, social, and environmental.

“Victorian Parlour Games: A Modern Host’s Guide to Classic Fun for Everyone” (Chronicle Books, 2024)
By Ned Wolfe, marketing and communications assistant at MIT Libraries

“Victorian Parlour Games” is a beautifully designed and compact hardcover volume full of the classic, often silly, games played in the late 19th century. The Victorians loved fun and played hundreds and hundreds of party games. This endlessly delightful party games book collects some of the very best for your reference and pleasure.

Arts, architecture, planning, and design

“Against Reason: Tony Smith, Sculpture, and Other Modernisms” (MIT Press, 2024)
Chapter by Judith Barry, professor in the Art, Culture, and Technology Program, with Kelli Anderson

This collection of essays reveals the depth and complexity of the sculpture of American modernist Tony Smith, placing his multifaceted practice in dialogue with contemporary voices. Barry’s chapter, "New Piece: Elective Geometries," describes the transformation of Smith’s sculpture into the form of a flipbook and centerpiece “pop-up.”

“Steina” (MIT Press, 2025)
Edited by Natalie Bell, curator at the MIT List Visual Arts Center

Accompanying the related exhibition at MIT List Visual Arts Center and Buffalo AKG Art Museum, “Steina” brings renewed recognition to Steina (b. 1940, Iceland), tracing her oeuvre from early collaborative works with her partner Woody Vasulka to her independent explorations of optics and a liberated, non-anthropocentric subjectivity.

“Jewish Theatrical Resources: A Guide for Theaters Producing Jewish Work” (Alliance for Jewish Theater, 2025)
Chapter by Marissa Friedman, marketing and communications manager in the Art, Culture, and Technology Program; Jenna Clark Embry; Robin Goldberg; Gabrielle Hoyt; Stephanie Kane; Alix Rosenfeld; and Marissa Shadburn

Produced by the Alliance for Jewish Theatre, this guide was created to help non-Jewish theaters produce Jewish plays with authenticity, cultural awareness, and care. Friedman contributes a chapter on dramaturgy, exploring how the primary role of a dramaturg is to support a playwright and production team in articulating their artistic vision, and setting forth an ideal model for the dramaturgy of a Jewish play, with both a theatrical dramaturg and a Jewish dramaturg.

“Play It Again, Sam: Repetition in the Arts” (MIT Press, 2025)
By Samuel Jay Keyser, the Peter de Florez emeritus professor of linguistics

Leonard Bernstein, in his famous Norton Lectures, extolled repetition, saying that it gave poetry its musical qualities and that music theorists’ refusal to take it seriously did so at their peril. “Play It Again, Sam” takes Bernstein seriously. In this book, Keyser explores why we enjoy works of poetry, music, and painting, and how repetition plays a central part in the pleasure.

“The Moving Image: A User’s Manual” (MIT Press, 2025)
By Peter B. Kaufman, associate director of development at MIT Open Learning

Video is today’s most popular information medium. Two-thirds of the world’s internet traffic is video. Americans get their news and information more often from screens and speakers than through any other means. “The Moving Image” is the first authoritative account of how we have arrived here, together with the first definitive manual to help writers, educators, and publishers use video more effectively.

“Beyond Ruins: Reimagining Modernism” (ArchiTangle, 2024)
Edited by Raafat Majzoub SM ’17, visiting lecturer at the Art, Culture, and Technology Program; and Nicolas Fayad

This book explores the renovation of modern architecture in the Global South as a tool for self-determination and community-building. Focusing on the Oscar Niemeyer Guest House in Tripoli, Lebanon, Majzoub and Fayad examine heritage as a political and material process. Through case studies, visual essays, and conversations with architects, artists, and theorists, the book addresses challenges of preservation, gaps in archiving, and the need for new forms of architectural practice.

“The Equitably Resilient City: Solidarities and Struggles in the Face of Climate Crisis” (MIT Press, 2024)
By Lawrence J. Vale, the Ford Professor of Urban Design and Planning and associate dean of the MIT School of Architecture and Planning; and Zachary B. Lamb

Too often the places most vulnerable to climate change are those that are home to people with the fewest economic and political resources. And while some leaders are starting to take action to reduce climate risks, many early adaptation schemes have actually made preexisting inequalities worse. In this book, Vale and Lamb ask how cities can adapt to climate change and other threats while also doing right by disadvantaged residents.

Novel and biography

“The Novice of Thanatos: An Epic Dark Fantasy of Horror, Death, and Necromancy” (Satirrell Publishing, 2025)
By Scott Austin Tirrell, director of administration and finance at the Art, Culture, and Technology Program

A fantasy novel that follows 11-year-old Mishal, a gifted yet troubled boy inducted into the secretive Order of Thanatos. Set in the grim and mystic realm of Lucardia, the story is framed as a first-person memoir chronicling Mishal’s initiation as a novice psychopomp — one who guides the dead across the Threshold into the afterlife. As Mishal navigates the Order’s rigid hierarchy, academic rigor, and spiritual mysteries, he begins to uncover unsettling truths about death, the soul, and the hidden agendas of those in power. Haunted by a spirit he cannot abandon and burdened by a forbidden artifact, Mishal must decide whom to trust and what to believe as his abilities grow — and as the line between duty and damnation begins to blur.

For young readers

“I Love You Bigger Than Everything That’s Big” (Stillwater River Publications, 2024)
By Lindsay Bartholomew, exhibit content and experience developer at MIT Museum, and illustrated by Sequoia Bostick

How much can you love someone? Higher than you can reach? Longer than a river? Bigger than the sky? The real answer — bigger than everything that’s big!

“A Century for Caroline” (Denene Millner Books / Simon and Schuster, 2025)
By Kaija Langley, director of development at MIT Libraries, and illustrated by TeMika Grooms

A great-grandma imparts the wisdom gained over her 100 years to an eager little girl in this tender picture book tribute to family and living a long, purposeful, beautiful life.

“All the Rocks We Love” (Penguin Random House, 2024)
By Taylor Perron, the Cecil and Ida Green Professor of Earth, Atmospheric and Planetary Sciences, and Lisa Varchol Perron, and illustrated by David Scheirer

It’s no secret that children love rocks: They appear in jacket pockets, on windowsills, in the car, in their hiding places, and most often, in little grips. This book is an appreciation of rocks’ versatility and appeal, paired with the presentation of real types of rocks and their play-worthy attributes. 

Evelyn Wang ’00 knows a few things about engineering solutions to hard problems. After all, she invented a way to pull water out of thin air.

Now, Wang is applying that problem-solving experience — and an enduring sense of optimism — toward the critical issue of climate change, to strengthen the American energy economy and ensure resilience for all.

Wang, a mechanical engineering professor by trade, began work this spring as MIT’s first vice president for energy and climate, overseeing the Institute’s expanding work on climate change. That means broadening the Institute’s already-wide research portfolio, scaling up existing innovations, seeking new breakthroughs, and channeling campus community input to drive work forward.

“MIT has the potential to do so much, when we know that climate, energy, and resilience are paramount to events happening around us every day,” says Wang, who is also the Ford Professor of Engineering at MIT. “There’s no better place than MIT to come up with the transformational solutions that can help shape our world.”

That also means developing partnerships with corporate allies, startups, government, communities, and other organizations. Tackling climate change, Wang says, “requires a lot of partnerships. It’s not an MIT-only endeavor. We’re going to have to collaborate with other institutions and think about where industry can help us deploy and scale so the impact can be greater.”

She adds: “The more partnerships we have, the more understanding we have of the best pathways to make progress in difficult areas.”

From MIT to ARPA-E

An MIT faculty member since 2007, Wang leads the Device Research Lab. Along with collaborators, she identifies new materials and optimizations based on heat and mass transport processes that unlock the creation of leading-edge innovations. Her development of the device that extracts water from even very dry air led Foreign Policy Magazine to name her its 2017 Global ReThinker, and she won the 2018 Eighth Prince Sultan bin Abdulaziz International Prize for Water.

Her research also extends to other areas such as energy and desalination research. In 2016, Wang and several colleagues announced a device based on nanophotonic crystals with the potential to double the amount of power produced by a given area of solar panels, which led to one of her graduate researchers on the project to co-found the startup Antora Energy. More recently, Wang and colleagues developed an aerogel that improves window insulation, now being commercialized through her former graduate students in a startup, AeroShield.

Wang also spent two years recently as director of the U.S. Department of Energy’s Advanced Research Projects Agency-Energy (ARPA-E), which supports early-stage R&D on energy generation, storage, and use.  Returning to MIT, she began her work as vice president for energy and climate in April, engaging with researchers, holding community workshops, and planning to build partnerships.

“I’ve been energized coming back to the Institute, given the talented students, the faculty, the staff. It’s invigorating to be back in this community,” Wang says. “People are passionate, excited, and mission-driven, and that’s the energy we need to make a big impact in the world.”

Wang is also working to help align the Institute’s many existing climate efforts. This includes the Climate Project at MIT, an Institute-wide presidential initiative announced in 2024, which aims to accelerate and scale up climate solutions while generating new tools and policy proposals. All told, about 300 MIT faculty conduct research related to climate issues in one form or another.

“The fact that there are so many faculty working on climate is astounding,” Wang says. “Everyone’s doing exciting work, but how can we leverage our unique strengths to create something bigger than the sum of its parts? That’s what I’m working toward. We’ve spun out so many technologies. How do we do more of that? How do we do that faster, and in a way so the world will feel the impact?”

A deep connection to campus — and strong sense of optimism

Understanding MIT is one of Wang’s strengths, given that she has spent over two decades at the Institute.

Wang earned her undergraduate degree from MIT in mechanical engineering, and her MS and PhD in mechanical engineering from Stanford University. She has held several chaired faculty positions at MIT. In 2008, Wang was named the Esther and Harold E. Edgerton Assistant Professor; in 2015, she was named the Gail E. Kendall Professor; and in 2021, she became the Ford Professor of Engineering. Wang served as head of the Department of Mechanical Engineering from 2018 through 2022.

As it happens, Wang’s parents, Kang and Edith, met as graduate students at the Institute. Her father, an electrical engineer, became a professor at the University of California at Los Angeles. Wang also met her husband at MIT, and both of her brothers graduated from the Institute.

Along with her deep institutional knowledge, administrative experience, and track record as an innovator, Wang is bringing several other things to her new role as vice president for climate: a sense of urgency about the issue, coupled with a continual sense of optimism that innovators can meet society’s needs.

“I think optimism can make a difference, and is great to have in the midst of collective challenge,” Wang says. “We’re such a mission-driven university, and people come here to solve real-world problems.”

That hopeful approach is why Wang describes the work as not only as a challenge but also a generational opportunity. “We have the chance to design the world we want,” she says, “one that’s cleaner, more sustainable and more resilient. This future is ours to shape and build together.”

Wang thinks MIT contains many examples of world-shaping progress, She cites MIT’s announcement this month of the creation of the Schmidt Laboratory for Materials in Nuclear Technologies, at the MIT Plasma Science and Fusion center, to conduct research on next-generation materials that could help enable the construction of fusion power plants. Another example Wang references is MIT research earlier this year on developing clean ammonia, a way to make the world’s most widely-produced chemical with drastically-reduced greenhouse gas emissions.

“Those solutions could be breakthroughs,” Wang says. “Those are the kinds of things that give us optimism. There’s still a lot of research to be done, but it suggests the potential of what our world can be.”

Optimism: There’s that word again.

“Optimism is the only way to go,” Wang says. “Yes, the world is challenged. But this is where MIT’s strengths — in research, innovation, and education — can bring optimism to the table.”