In addition to patrolling the body for foreign invaders, the immune system also hunts down and destroys cells that have become cancerous or precancerous. However, some cancer cells end up evading this surveillance and growing into tumors.

Once established, tumor cells often send out immunosuppressive signals, which leads T cells to become “exhausted” and unable to attack the tumor. In recent years, some cancer immunotherapy drugs have shown great success in rejuvenating those T cells so they can begin attacking tumors again.

While this approach has proven effective against cancers such as melanoma, it doesn’t work as well for others, including lung and ovarian cancer. MIT Associate Professor Stefani Spranger is trying to figure out how those tumors are able to suppress immune responses, in hopes of finding new ways to galvanize T cells into attacking them.

“We really want to understand why our immune system fails to recognize cancer,” Spranger says. “And I’m most excited about the really hard-to-treat cancers because I think that’s where we can make the biggest leaps.”

Her work has led to a better understanding of the factors that control T-cell responses to tumors, and raised the possibility of improving those responses through vaccination or treatment with immune-stimulating molecules called cytokines.

“We’re working on understanding what exactly the problem is, and then collaborating with engineers to find a good solution,” she says.

Jumpstarting T cells

As a student in Germany, where students often have to choose their college major while still in high school, Spranger envisioned going into the pharmaceutical industry and chose to major in biology. At Ludwig Maximilian University in Munich, her course of study began with classical biology subjects such as botany and zoology, and she began to doubt her choice. But, once she began taking courses in cell biology and immunology, her interest was revived and she continued into a biology graduate program at the university.

During a paper discussion class early in her graduate school program, Spranger was assigned to a Science paper on a promising new immunotherapy treatment for melanoma. This strategy involves isolating tumor-infiltrating T-cells during surgery, growing them into large numbers, and then returning them to the patient. For more than 50 percent of those patients, the tumors were completely eliminated.

“To me, that changed the world,” Spranger recalls. “You can take the patient’s own immune system, not really do all that much to it, and then the cancer goes away.”

Spranger completed her PhD studies in a lab that worked on further developing that approach, known as adoptive T-cell transfer therapy. At that point, she still was leaning toward going into pharma, but after finishing her PhD in 2011, her husband, also a biologist, convinced her that they should both apply for postdoc positions in the United States.

They ended up at the University of Chicago, where Spranger worked in a lab that studies how the immune system responds to tumors. There, she discovered that while melanoma is usually very responsive to immunotherapy, there is a small fraction of melanoma patients whose T cells don’t respond to the therapy at all. That got her interested in trying to figure out why the immune system doesn’t always respond to cancer the way that it should, and in finding ways to jumpstart it.

During her postdoc, Spranger also discovered that she enjoyed mentoring students, which she hadn’t done as a graduate student in Germany. That experience drew her away from going into the pharmaceutical industry, in favor of a career in academia.

“I had my first mentoring teaching experience having an undergrad in the lab, and seeing that person grow as a scientist, from barely asking questions to running full experiments and coming up with hypotheses, changed how I approached science and my view of what academia should be for,” she says.

Modeling the immune system

When applying for faculty jobs, Spranger was drawn to MIT by the collaborative environment of MIT and its Koch Institute for Integrative Cancer Research, which offered the chance to collaborate with a large community of engineers who work in the field of immunology.

“That community is so vibrant, and it’s amazing to be a part of it,” she says.

Building on the research she had done as a postdoc, Spranger wanted to explore why some tumors respond well to immunotherapy, while others do not. For many of her early studies, she used a mouse model of non-small-cell lung cancer. In human patients, the majority of these tumors do not respond well to immunotherapy.

“We build model systems that resemble each of the different subsets of non-responsive non-small cell lung cancer, and we’re trying to really drill down to the mechanism of why the immune system is not appropriately responding,” she says.

As part of that work, she has investigated why the immune system behaves differently in different types of tissue. While immunotherapy drugs called checkpoint inhibitors can stimulate a strong T-cell response in the skin, they don’t do nearly as much in the lung. However, Spranger has shown that T cell responses in the lung can be improved when immune molecules called cytokines are also given along with the checkpoint inhibitor.

Those cytokines work, in part, by activating dendritic cells — a class of immune cells that help to initiate immune responses, including activation of T cells.

“Dendritic cells are the conductor for the orchestra of all the T cells, although they’re a very sparse cell population,” Spranger says. “They can communicate which type of danger they sense from stressed cells and then instruct the T cells on what they have to do and where they have to go.”

Spranger’s lab is now beginning to study other types of tumors that don’t respond at all to immunotherapy, including ovarian cancer and glioblastoma. Both the brain and the peritoneal cavity appear to suppress T-cell responses to tumors, and Spranger hopes to figure out how to overcome that immunosuppression.

“We’re specifically focusing on ovarian cancer and glioblastoma, because nothing’s working right now for those cancers,” she says. “We want to understand what we have to do in those sites to induce a really good anti-tumor immune response.”

Three MIT payloads will soon hitch a ride to the moon in a step toward establishing a permanent base on the lunar surface.

In the coming days, weather permitting, MIT engineers and scientists will send three payloads into space, on a course set for the moon’s south polar region. Scientists believe this area, with its permanently shadowed regions, could host hidden reservoirs of frozen water, which could serve to sustain future lunar settlements and fuel missions beyond the moon.

NASA plans to send astronauts to the moon’s south pole in 2027 as part of the Artemis III mission, which will be the first time humans touch down on the lunar surface since the Apollo era and the first time any human sets foot on its polar region. In advance of that journey, the MIT payloads will provide data about the area that can help prepare Artemis astronauts for navigating the frozen terrain.

The payloads include two novel technologies — a small depth-mapping camera and a thumb-sized mini-rover — along with a wafer-thin “record,” etched with the voices of people from around the world speaking in their native languages. All three payloads will be carried by a larger, suitcase-sized rover built by the space contractor Lunar Outpost.

As the main rover drives around the moon’s surface, exploring the polar terrain, the MIT camera, mounted on the front of the rover, will take the first ever 3D images of the lunar landscape captured from the surface of the Moon using time of flight technology. These images will beam back to Earth, where they can be used to train Artemis astronauts in visual simulations of the polar terrain and can be incorporated into advanced spacesuits with synthetic vision helmets.

Meanwhile, the mini-rover, dubbed “AstroAnt,” will wheel around the roof of the main rover and take temperature readings to monitor the larger vehicle’s operation. If it’s successful, AstroAnt could work as part of a team of miniature helper bots, performing essential tasks in future missions, such as clearing dust from solar panels and checking for cracks in lunar habitats and infrastructure.

All three MIT payloads, along with the Lunar Outpost rover, will launch to the moon aboard a SpaceX Falcon 9 rocket and touch down in the moon’s south polar region in a lander built by space company Intuitive Machines. The mission as a whole, which includes a variety of other payloads in addition to MIT’s, is named IM-2, for Intuitive Machines’ second trip to the moon. IM-2 aims to identify the presence and amount of water-ice on the moon’s south pole, using a combination of instruments, including an ice drill mounted to the lander, and a robotic “hopper” that will bounce along the surface to search for water in hard-to-reach regions.

The lunar landing, which engineers anticipate will be around noon on March 6, will mark the first time MIT has set active technology on the moon’s surface since the Apollo era, when MIT’s Instrumentation Laboratory, now the independent Draper Laboratory, provided the landmark Apollo Guidance Computer that navigated astronauts to the moon and back.

MIT engineers see their part in the new mission, which they’ve named “To the Moon to Stay,” as the first of many on the way to establishing a permanent presence on the lunar surface.

“Our goal is not just to visit the moon but to build a thriving ecosystem that supports humanity’s expansion into space,” says Dava Newman, Apollo Program Professor of Astronautics at MIT, director of the MIT Media Lab, and former NASA deputy administrator.

Institute’s roots

MIT’s part in the lunar mission is led by the Space Exploration Initiative (SEI), a research collaborative within the Media Lab that aims to enable a “sci-fi future” of space exploration. The SEI, which was founded in 2016 by media arts and sciences alumna Ariel Ekblaw SM ’17, PhD ’20, develops, tests, and deploys futuristic space-grade technologies that are intended to help humans establish sustainable settlements in space.

In the spring of 2021, SEI and MIT’s Department of Aeronautics and Astronautics (AeroAstro) offered a course, MAS.839/16.893 (Operating in the Lunar Environment), that tasked teams of students to design payloads that meet certain objectives related to NASA’s Artemis missions to the moon. The class was taught by Ekblaw and AeroAstro’s Jeffrey Hoffman, MIT professor of the practice and former NASA astronaut, who helped students test their payload designs in the field, including in remote regions of Norway that resemble the moon’s barren landscape, and in parabolic flights that mimic the moon’s weak gravity.

Out of that class, Ekblaw and Hoffman chose to further develop two payload designs: a laser-based 3D camera system and the AstroAnt — a tiny, autonomous inspection robot. Both designs grew out of prior work. AstroAnt was originally a side project as part of Ekblaw’s PhD, based on work originally developed by Artem Dementyev in the Media Lab’s Responsive Environments group, while the 3D camera was a PhD focus for AeroAstro alumna Cody Paige ’23, who helped develop and test the camera design and implement VR/XR technology with Newman, in collaboration with NASA Ames Research Center.

As both designs were fine-tuned, Ekblaw raised funds and established a contract with Lunar Outpost (co-founded by MIT AeroAstro alumnus Forrest Meyen SM ’13, PhD ’17) to pair the payloads with the company’s moon-bound rover. SEI Mission Integrator Sean Auffinger oversaw integration and test efforts, together with Lunar Outpost, to support these payloads for operation in a novel, extreme environment.

“This mission has deep MIT roots,” says Ekblaw, who is the principal investigator for the MIT arm of the IM-2 mission, and a visiting scientist at the Media Lab. “This will be historic in that we’ve never landed technology or a rover in this area of the lunar south pole. It’s a really hard place to land — there are big boulders, and deep dust. So, it’s a bold attempt.”

Systems on

The site of the IM-2 landing is Mons Mouton Plateau — a flat-topped mountain at the moon’s south pole that lies just north of Shackleton Crater, which is a potential landing site for NASA’s Artemis astronauts. After the Intuitive Machines lander touches down, it will effectively open its garage door and let Lunar Outpost’s rover drive out to explore the polar landscape. Once the rover acclimates to its surroundings, it will begin to activate its instruments, including MIT’s 3D camera.

“It will be the first time we’re using this specific imaging technology on the lunar surface,” notes Paige, who is the current SEI director.

The camera, which will be mounted on the front of the main rover, is designed to shine laser light onto a surface and measure the time it takes for the light to bounce back to the camera. This “time-of-flight” is a measurement of distance, which can also be translated into surface topography, such as the depth of individual craters and crevices.

“Because we’re using a laser light, we can look without using sunlight,” Paige explains. “And we don’t know exactly what we’ll find. Some of the things we’re looking for are centimeter-sized holes, in areas that are permanently shadowed or frozen, that might contain water-ice. Those are the kinds of landscapes we’re really excited to see.”

Paige expects that the camera will send images back to Earth in next-day data packets, which the MIT science team will process and analyze as the rover traverses the terrain.

As the camera maps the moon’s surface, AstroAnt — which is smaller and lighter than an airpod case — will deploy from a tiny garage atop the main rover’s roof. The AstroAnt will drive around on magnetic wheels that allow it to stick to the rover’s surface without falling off. To the AstroAnt’s undercarriage, Ekblaw and her team, led by Media Lab graduate student Fangzheng Liu, fixed a thermopile — a small sensor that takes measurements of the main rover’s temperature, which can be used to monitor the vehicle’s thermal performance. 

“If we can test this one AstroAnt on the moon, then we imagine having these really capable, roving swarms that can help astronauts do autonomous repair, inspection, diagnostics, and servicing,” Ekblaw says. “In the future, we could put little windshield wipers on them to help clear dust from solar panels, or put a pounding bar on them to induce tiny vibrations to detect defects in a habitat. There’s a lot of potential once we get to swarm scale.”

Eyes on the moon

The third MIT payload that will be affixed to the main rover is dubbed the Humanity United with MIT Art and Nanotechnology in Space, or HUMANS project. Led by MIT AeroAstro alumna Maya Nasr ’18, SM ’21, PhD ’23, HUMANS is a 2-inch disc made from a silicon wafer engraved with nanometer-scale etchings using technology provided by MIT.nano. The engravings are inspired by The Golden Record, a phonograph record that was sent into space with NASA’s Voyager probes in 1977. The HUMANS record is engraved with recordings of people from around the world, speaking in their native languages about what space exploration and humanity mean to them.

“We are carrying the hopes, dreams, and stories of people from all backgrounds,” Nasr says. “(It’s a) powerful reminder that space is not the privilege of a few, but the shared legacy of all.”

The MIT Media Lab plans to display the March 6 landing on a screen in the building’s atrium for the public to watch in real-time. Researchers from MIT’s Department of Architecture, led by Associate Professor Skylar Tibbits, have also built a lunar mission control room — a circular, architectural space where the engineers will monitor and control the mission’s payloads. If all goes well, the MIT team see the mission as the first step toward putting permanent boots on the surface of the moon, and even beyond.

“Our return to the Moon is not just about advancing technology — it’s about inspiring the next generation of explorers who are alive today and will travel to the moon in their lifetime,” Ekblaw says. “This historic mission for MIT brings students, staff and faculty together from across the Institute on a foundational mission that will support a future sustainable lunar settlement.”

The following is part of a series of short interviews from the Department of Electrical Engineering and Computer Science (EECS) featuring a student describing themselves and life at MIT. Today’s interviewee, Titus Roesler, is a senior majoring in electrical science and engineering. As a first-year at MIT, Roesler joined the Experimental Study Group (ESG), a learning community that offers new MIT students the general Institute requirements (GIRs) in a small, tight-knit class setting. Roesler stuck around as an associate advisor in subsequent years for new cohorts of first-year ESG students, as a teaching assistant for classes on calculus and group theory, and as an instructor for special seminars in electrical engineering that he designed from scratch and then taught. Roesler’s commitment to his academic community also goes deep. Besides his teaching work, for which he was recently honored with the EECS Undergraduate Teaching Award, he is a member of the Undergraduate Student Advisory Group in EECS (USAGE), which provides student feedback to the department. 

Q: Tell us about one teacher from your past who had an influence on the person you’ve become.

A: While a student in ESG, I took ES.1801 (Single-Variable Calculus), ES.1802 (Multivariable Calculus), and ES.1803 (Differential Equations), all with Gabrielle Stoy. One morning in late spring, Gabrielle asked me to stick around after class to speak with her. (I wondered which course policy I had violated, and worried throughout the lecture.) Instead, Gabrielle asked me if I would apply to be a teaching assistant for an ESG math class the next semester. I was ecstatic — and thus began my “teaching career” at MIT! Gabrielle formally retired from teaching mathematics in ESG in 2024, but we teamed up again to offer a special seminar on group theory over IAP [Independent Activities Period] 2025.

Q: What is one conversation that changed the trajectory of your life?

A: I’m grateful for all the conversations I’ve had with Prof. Denny Freeman. I appreciate his kindness, wisdom, and willingness to find time to discuss career plans, research, and education with me. I’ve always left his office feeling more ambitious and optimistic than I did when I walked in.

Q: Do you have a bucket list? If so, share one or two of the items on it.

A: Running the Boston Marathon was on my bucket list for a few years, and I checked that off in 2024. Beyond that, I would love to explore Antarctica — perhaps by living and working at a research station for a year.

Q: What’s your favorite key on a standard computer keyboard, and why?

A: The backslash ( \ ) key is my favorite. I use it often for TEX commands when typesetting.

Q: If you suddenly won the lottery, what would you spend some of the money on?

A: A bulk order of Hagoromo chalk — the so-called “Rolls-Royce of chalk!”

Q: If you had to teach a really in-depth class about a niche topic, what would you pick?

A: In the context of signal processing, filters sift out desired frequency bands while attenuating others. I’d be interested in teaching a class on the theory and practice behind filter design — constructing a filter that satisfies a set of specifications. For example, analog or digital? Finite impulse response or infinite impulse response? Group delay? Causality? Stability? Practical implementation? I’m not an expert in filter design myself, but I’d appreciate the opportunity to consolidate what I’ve learned so far and study the topic in greater depth.

Spencer Paysinger has already been many things in his life, including a Super Bowl-winning linebacker, a writer and producer of the hit television series “All-American,” and local-business entrepreneur. But as he explained during his keynote speech at MIT’s 51st annual event celebrating the life and legacy of Martin Luther King Jr., Paysinger would prefer to think about his journey in additional terms: whether he has been able to serve others along the way.

“As I stand up here today talking about Dr. King’s mission, Dr. King’s dream, why we’re all here today, to me it all leans back into community,” Paysinger said. “I want to be judged by what I have done for others.”

Being able to reach out to others, in good times and bad, was a theme of the annual event, which took place in MIT’s Walker Memorial (Building 50), on Thursday. As Paysinger noted, his own career is marked by being a “team player” and finding reward in shared endeavors.

“For me, I’m at my best when I have people on the right and on the left of me attempting to reach the same dream,” Paysinger said. “We can have different ideologies, we can come from different backgrounds, of race, socioeconomic backgrounds. … At the end of the day it comes back to the mindset we need to have. It’s rooted in community, it’s rooted in togetherness.”

The event featured an array of talks delivered by students, campus leaders, and guests, along with musical interludes, and drew hundreds from the MIT community.

In opening remarks, MIT President Sally A. Kornbluth praised Paysinger, saying his “perseverance and tenacity are a fantastic example to us all.”

Kornbluth also spoke about the values, and value, of MIT itself. American universities and colleges, she noted, have long “been a point of national pride and a source of international envy. … They and we have always been valued as centers of excellence creativity, innovation, and an infinitely renewable source of leadership.”

Moving forward, Kornbluth noted, the MIT community will continue to pursue excellence and provide mutual respect for others.

“MIT is in the talent business,” Kornbluth said. “Our success, and living up to our great mission, depends on our ability to attract extraordinarily talented people and to create a community in which everyone earns a place here to do their very best work. … Everyone at MIT is here because they deserve to be here. Every staff member, every faculty member, every postdoc, every student, every one of us. Every one of us is a full member of this community, and every member of our community is valued as a human being, and valued for what they contribute to our mission.”

Paysinger lauded the array of speakers as well as the friendly atmosphere at the event, where attendees sat around luncheon tables, talking and getting to know each other before and after the slate of talks.

“You guys actively and literally in 45 minutes have changed my view of what MIT is,” Paysinger said.

In his NFL career, Paysinger was a linebacker who played with the New York Giants, Miami Dolphins, and Carolina Panthers, from 2011 through 2017, appearing in 94 regular-season games and five playoff games. He saw action in Super Bowl XLVI, when the Giants beat the New England Patriots, 22-17, something he joked about a few times for his Massachusetts audience. Paysinger’s former New York Giants teammate, fellow linebacker Mark Herzlich, was also in attendance on Thursday.

Paysinger grew up in South Central Los Angeles, long perceived from the outside as a place of danger and deprivation. And while he experienced those things, Paysinger said, his home neighborhood also had its “all-American” side, as kids raced bikes down the block and grew to know each other. Paysinger attended Beverly Hills High School, starring as a wide receiver, then signed with the University of Oregon, where he converted to linebacker. Oregon and Paysinger reached college football’s national championship game in his senior season, 2010.

In his talk, Paysinger emphasized the twists and turns of his journey through football, from changing positions on the field to changing teams. He noted that, in sports as in life, moving beyond our comfort zone can help us thrive in the long run.

“I was scared, I wasn’t sure of myself, when my coaches decided to make that change for me,” Paysinger said. However, he added, “I knew that [from] leaning into the uncomfortableness of the moment, the other side could be greater for me.”

The NFL soon beckoned, along with a Super Bowl ring. But Paysinger received a jolt beyond the boundaries of sports in 2015, when his former Giants teammate and close friend Tyler Sash died suddently at age 27. Among other things, Paysinger began thinking about life after football more systematically and began his screenwriting efforts in earnest, even as his football career was still ongoing.

“All-American,” now entering its 7th season on the CW Network, is loosely based on his own background, capturing the dynamics of his experiences as a player and team member. It has become one of the longest-running sports-based shows on television. Paysinger is also an entrepreneur who founded Hilltop Kitchen and Coffee, a chain of eateries in underserved areas around Los Angeles, and has helped develop other local businesses as well.

And while every new venture is a fresh challenge, Paysinger said, we can often accomplish more than we realize: “I’m not coming from a mindset of deciding whether I can or can’t do something, but if I want to or not.”

Sophomore Michael Ewing provided welcoming remarks and introduced Paysinger. He read aloud a quote from King chosen as a central motif of this year’s celebration: “We must come to see that the end we seek is a society at peace with itself, a society that can live with its conscience.”

For his own part, Ewing said, “When I read these words, I think of a society that aspires to improve its circumstances, address existing issues, and create a more positive and just environment for all.” At MIT, Ewing added, there is “a community where students, professors, and others come together to achieve at the highest levels, united by a shared desire to learn and grow. … The process of collaborating, disagreeing, building with others who are different — this is the key to growth and development.”

The annual MLK Celebration featured further reflections from students, including second-year undergraduate Siddhu Pachipala, a political science and economics double-major. Pachipala began his remarks by recounting a social media exchange he once had with a congressional account, the tenor of which he soon regretted.

“Looking back, I think it was a missed opportunity,” Pachipala said. “Why was my first instinct … to turn it into a battle? … We train ourselves to believe that if we’re not scoring hits, we’re losing, and gestures of decency are traps, that an extended hand must be slapped away. Martin Luther King Jr. took politics to be something more substantial. He had a serious vision of justice, one we’ve gathered today to honor. But he knew that justice had a prerequisite: friendship.”

Elshareef Kabbashi, a graduate student in architecture, offered additional remarks, noting that “Dr. King’s dream was never confined to a single movement, nation, or moment in history,” but rather aimed at creating “human dignity everywhere.”

E. Denise Simmons, mayor of the City of Cambridge, also spoke, and lauded “the entire MIT community for keeping this tradition alive for 51 years.” She added: “It’s Dr. King’s wisdom, his courage, his moral clarity, that helped light the path forward. And I ask each of you to continue to shine that light.”

The luncheon included the presentation of the annual Dr. Martin Luther King Jr. Leadership Awards Recipients, given this year to Cordelia Price ’78, SM ’80; Pouya Alimagham; Ciarra Ortiz; Sahal Ahmed; William Gibbs; and Maxine Samuels.

On a day full of thoughts about King and his vision, Paysinger underscored the salience of community by highlighting another of his favorite King passages: “Every man must decide whether he will walk in the light of creative altruism or in the darkness of destructive selfishness. This is the judgment. Life’s most persistent and urgent question is, ‘What are you doing for others?’” 

MIT senior Markey Freudenburg-Puricelli and alumnae Abigail (“Abbie”) Schipper ’24 and Rachel Zhang ’21 have been selected as Gates Cambridge Scholars and will begin graduate studies this fall in the field of their choice at Cambridge University in the U.K.

Now celebrating its 25th year, the Gates Cambridge program provides fully funded post-graduate scholarships to outstanding applicants from countries outside of the U.K. The mission of Gates Cambridge is to build a global network of future leaders committed to changing the world for the better.

Students interested in applying to Gates Cambridge should contact Kim Benard, associate dean of distinguished fellowships in Career Advising and Professional Development.

Markey Freudenburg-Puricelli

Freudenburg-Puricelli is majoring in Earth, atmospheric, and planetary sciences and minoring in Spanish. Her passion for geoscience has led her to travel to different corners of the world to conduct geologic fieldwork. These experiences have motivated her to pursue a career in developing scientific policy and environmental regulation that can protect those most vulnerable to climate change. As a Gates Cambridge Scholar, she will pursue an MPhil in environmental policy.

Arriving at MIT, Freudenburg-Puricelli joined the Terrascope first-year learning community, which focuses on hands-on education relating to global environmental issues. She then became an undergraduate research assistant in the McGee Lab for Paleoclimate and Geochronology, where she gathered and interpreted data used to understand climate features of permafrost across northern Canada.

Following a summer internship in Chile researching volcanoes at the Universidad Católica del Norte, Freudenburg-Puricelli joined the Gehring Lab for Plant Genetics, Epigenetics, and Seed Biology. Last summer, she traveled to Peru to work with the Department of Paleontology at the Universidad Nacional de Piura, conducting fieldwork and preserving and organizing fossil specimens. Freudenburg-Puricelli has also done fieldwork on sedimentology in New Mexico, geological mapping in the Mojave Desert, and field oceanography onboard the SSV Corwith Cramer.

On campus, Freudenburg-Puricelli is an avid glassblower and has been a teaching assistant at the MIT glassblowing lab. She is also a tour guide for the MIT Office of Admissions and has volunteered with the Department of Earth, Atmospheric and Planetary Sciences’ first-year pre-orientation program.

Abigail “Abbie” Schipper ’24

Originally from Portland, Oregon, Schipper graduated from MIT with a BS in mechanical engineering and a minor in biology. At Cambridge, she will pursue an MPhil in engineering, researching medical devices used in pre-hospital trauma systems in low- and middle-income countries with the Cambridge Health Systems Design group.

At MIT, Schipper was a member of MIT Emergency Medical Services, volunteering on the ambulance and serving as the heartsafe officer and director of ambulance operations. Inspired by her work in CPR education, she helped create the LifeSaveHer project, which aims to decrease the gender disparity in out-of-hospital cardiac arrest survival outcomes through the creation of female CPR mannequins and associated research. This team was the first-place winner of the 2023 PKG IDEAS Competition and a recipient of the Eloranta Research Fellowship.

Schipper’s work has also focused on designing medical devices for low-resource or extreme environments. As an undergraduate, she performed research in the lab of Professor Giovanni Traverso, where she worked on a project designing a drug delivery implant for regions with limited access to surgery. During a summer internship at the University College London Collaborative Center for Inclusion Health, she worked with the U.K.’s National Health Service to create durable, low-cost carbon dioxide sensors to approximate the risk of airborne infectious disease transmission in shelters for people experiencing homelessness.

After graduation, Schipper interned at SAGA Space Architecture through MISTI Denmark, designing life support systems for an underwater habitat that will be used for astronaut training and oceanographic research.

Schipper was a member of the Concourse learning community, Sigma Kappa Sorority, and her living group, Burton 3rd. In her free time, she enjoys fixing bicycles and playing the piano.

Rachel Zhang ’21

Zhang graduated from MIT with a BS in physics in 2021. During her senior year, she was a recipient of the Joel Matthews Orloff Award. She then earned an MS in astronomy at Northwestern University. An internship at the Center for Computational Astrophysics at the Flatiron Institute deepened her interest in the applications of machine learning for astronomy. At Cambridge, she will pursue a PhD in applied mathematics and theoretical physics. 

MIT senior Markey Freudenburg-Puricelli and recent alumna Abigail (“Abbie”) Schipper ’24 have been selected as Gates Cambridge Scholars and will begin graduate studies this fall in the field of their choice at Cambridge University in the U.K.

Now celebrating its 25th year, the Gates Cambridge program provides fully funded post-graduate scholarships to outstanding applicants from countries outside of the U.K. The mission of Gates Cambridge is to build a global network of future leaders committed to changing the world for the better.

Students interested in applying to Gates Cambridge should contact Kim Benard, associate dean of distinguished fellowships in Career Advising and Professional Development.

Markey Freudenburg-Puricelli

Freudenburg-Puricelli is majoring in Earth, atmospheric, and planetary sciences and minoring in Spanish. Her passion for geoscience has led her to travel to different corners of the world to conduct geologic fieldwork. These experiences have motivated her to pursue a career in developing scientific policy and environmental regulation that can protect those most vulnerable to climate change. As a Gates Cambridge Scholar, she will pursue an MPhil in environmental policy.

Arriving at MIT, Freudenburg-Puricelli joined the Terrascope first-year learning community, which focuses on hands-on education relating to global environmental issues. She then became an undergraduate research assistant in the McGee Lab for Paleoclimate and Geochronology, where she gathered and interpreted data used to understand climate features of permafrost across northern Canada.

Following a summer internship in Chile researching volcanoes at the Universidad Católica del Norte, Freudenburg-Puricelli joined the Gehring Lab for Plant Genetics, Epigenetics, and Seed Biology. Last summer, she traveled to Peru to work with the Department of Paleontology at the Universidad Nacional de Piura, conducting fieldwork and preserving and organizing fossil specimens. Freudenburg-Puricelli has also done fieldwork on sedimentology in New Mexico, geological mapping in the Mojave Desert, and field oceanography onboard the SSV Corwith Cramer.

On campus, Freudenburg-Puricelli is an avid glassblower and has been a teaching assistant at the MIT glassblowing lab. She is also a tour guide for the MIT Office of Admissions and has volunteered with the Department of Earth, Atmospheric and Planetary Sciences’ first-year pre-orientation program.

Abigail “Abbie” Schipper ’24

Originally from Portland, Oregon, Schipper graduated from MIT with a BS in mechanical engineering and a minor in biology. At Cambridge, she will pursue an MPhil in engineering, researching medical devices used in pre-hospital trauma systems in low- and middle-income countries with the Cambridge Health Systems Design group.

At MIT, Schipper was a member of MIT Emergency Medical Services, volunteering on the ambulance and serving as the heartsafe officer and director of ambulance operations. Inspired by her work in CPR education, she helped create the LifeSaveHer project, which aims to decrease the gender disparity in out-of-hospital cardiac arrest survival outcomes through the creation of female CPR mannequins and associated research. This team was the first-place winner of the 2023 PKG IDEAS Competition and a recipient of the Eloranta Research Fellowship.

Schipper’s work has also focused on designing medical devices for low-resource or extreme environments. As an undergraduate, she performed research in the lab of Professor Giovanni Traverso, where she worked on a project designing a drug delivery implant for regions with limited access to surgery. During a summer internship at the University College London Collaborative Center for Inclusion Health, she worked with the U.K.’s National Health Service to create durable, low-cost carbon dioxide sensors to approximate the risk of airborne infectious disease transmission in shelters for people experiencing homelessness.

After graduation, Schipper interned at SAGA Space Architecture through MISTI Denmark, designing life support systems for an underwater habitat that will be used for astronaut training and oceanographic research.

Schipper was a member of the Concourse learning community, Sigma Kappa Sorority, and her living group, Burton 3rd. In her free time, she enjoys fixing bicycles and playing the piano.

Maybe it’s a life hack or a liability, or a little of both. A surprising result in a new MIT study may suggest that people and animals alike share an inherent propensity to keep updating their approach to a task even when they have already learned how they should approach it, and even if the deviations sometimes lead to unnecessary error.

The behavior of “exploring” when one could just be “exploiting” could make sense for at least two reasons, says Mriganka Sur, senior author of the study published Feb. 18 in Current Biology. Just because a task’s rules seem set one moment doesn’t mean they’ll stay that way in this uncertain world, so altering behavior from the optimal condition every so often could help reveal needed adjustments. Moreover, trying new things when you already know what you like is a way of finding out whether there might be something even better out there than the good thing you’ve got going on right now.

“If the goal is to maximize reward, you should never deviate once you have found the perfect solution, yet you keep exploring,” says Sur, the Paul and Lilah Newton Professor in The Picower Institute for Learning and Memory and the Department of Brain and Cognitive Sciences at MIT. “Why? It’s like food. We all like certain foods, but we still keep trying different foods because you never know, there might be something you could discover.”

Predicting timing

Former research technician Tudor Dragoi, now a graduate student at Boston University, led the study in which he and fellow members of the Sur Lab explored how humans and marmosets, a small primate, make predictions about event timing.

Three humans and two marmosets were given a simple task. They’d see an image on a screen for some amount of time — the amount of time varied from one trial to the next within a limited range — and they simply had to hit a button (marmosets poked a tablet while humans clicked a mouse) when the image disappeared. Success was defined as reacting as quickly as possible to the image’s disappearance without hitting the button too soon. Marmosets received a juice reward on successful trials.

Though marmosets needed more training time than humans, the subjects all settled into the same reasonable pattern of behavior regarding the task. The longer the image stayed on the screen, the faster their reaction time to its disappearance. This behavior follows the “hazard model” of prediction in which, if the image can only last for so long, the longer it’s still there, the more likely it must be to disappear very soon. The subjects learned this and overall, with more experience, their reaction times became faster.

But as the experiment continued, Sur and Dragoi’s team noticed something surprising was also going on. Mathematical modeling of the reaction time data revealed that both the humans and marmosets were letting the results of the immediate previous trial influence what they did on the next trial, even though they had already learned what to do. If the image was only on the screen briefly in one trial, on the next round subjects would decrease reaction time a bit (presumably expecting a shorter image duration again) whereas if the image lingered, they’d increase reaction time (presumably because they figured they’d have a longer wait).

Those results add to ones from a similar study Sur’s lab published in 2023, in which they found that even after mice learned the rules of a different cognitive task, they’d arbitrarily deviate from the winning strategy every so often. In that study, like this one, learning the successful strategy didn’t prevent subjects from continuing to test alternatives, even if it meant sacrificing reward.

“The persistence of behavioral changes even after task learning may reflect exploration as a strategy for seeking and setting on an optimal internal model of the environment,” the scientists wrote in the new study.

Relevance for autism

The similarity of the human and marmoset behaviors is an important finding as well, Sur says. That’s because differences in making predictions about one’s environment is posited to be a salient characteristic of autism spectrum disorders. Because marmosets are small, are inherently social, and are more cognitively complex than mice, work has begun in some labs to establish marmoset autism models, but a key component was establishing that they model autism-related behaviors well. By demonstrating that marmosets model neurotypical human behavior regarding predictions, the study therefore adds weight to the emerging idea that marmosets can indeed provide informative models for autism studies.

In addition to Dragoi and Sur, other authors of the paper are Hiroki Sugihara, Nhat Le, Elie Adam, Jitendra Sharma, Guoping Feng, and Robert Desimone.

The Simons Foundation Autism Research Initiative supported the research through the Simons Center for the Social Brain at MIT.

Rain can freefall at speeds of up to 25 miles per hour. If the droplets land in a puddle or pond, they can form a crown-like splash that, with enough force, can dislodge any surface particles and launch them into the air.

Now MIT scientists have taken high-speed videos of droplets splashing into a deep pool, to track how the fluid evolves, above and below the water line, frame by millisecond frame. Their work could help to predict how spashing droplets, such as from rainstorms and irrigation systems, may impact watery surfaces and aerosolize surface particles, such as pollen on puddles or pesticides in agricultural runoff.

The team carried out experiments in which they dispensed water droplets of various sizes and from various heights into a pool of water. Using high-speed imaging, they measured how the liquid pool deformed as the impacting droplet hit the pool’s surface.

Across all their experiments, they observed a common splash evolution: As a droplet hit the pool, it pushed down below the surface to form a “crater,” or cavity. At nearly the same time, a wall of liquid rose above the surface, forming a crown. Interestingly, the team observed that small, secondary droplets were ejected from the crown before the crown reached its maximum height. This entire evolution happens in a fraction of a second.

Scientists have caught snapshots of droplet splashes in the past, such as the famous “Milk Drop Coronet” — a photo of a drop of milk in mid-splash, taken by the late MIT professor Harold “Doc” Edgerton, who invented a photographic technique to capture quickly moving objects.

The new work represents the first time scientists have used such high-speed images to model the entire splash dynamics of a droplet in a deep pool, combining what happens both above and below the surface. The team has used the imaging to gather new data central to build a mathematical model that predicts how a droplet’s shape will morph and merge as it hits a pool’s surface. They plan to use the model as a baseline to explore to what extent a splashing droplet might drag up and launch particles from the water pool.

“Impacts of drops on liquid layers are ubiquitous,” says study author Lydia Bourouiba, a professor in the MIT departments of Civil and Environmental Engineering and Mechanical Engineering, and a core member of the Institute for Medical Engineering and Science (IMES). “Such impacts can produce myriads of secondary droplets that could act as carriers for pathogens, particles, or microbes that are on the surface of impacted pools or contaminated water bodies. This work is key in enabling prediction of droplet size distributions, and potentially also what such drops can carry with them.”

Bourouiba and her mentees have published their results in the Journal of Fluid Mechanics. MIT co-authors include former graduate student Raj Dandekar PhD ’22, postdoc (Eric) Naijian Shen, and student mentee Boris Naar.

Above and below

At MIT, Bourouiba heads up the Fluid Dynamics of Disease Transmission Laboratory, part of the Fluids and Health Network, where she and her team explore the fundamental physics of fluids and droplets in a range of environmental, energy, and health contexts, including disease transmission. For their new study, the team looked to better understand how droplets impact a deep pool — a seemingly simple phenomenon that nevertheless has been tricky to precisely capture and characterize.

Bourouiba notes that there have been recent breakthroughs in modeling the evolution of a splashing droplet below a pool’s surface. As a droplet hits a pool of water, it breaks through the surface and drags air down through the pool to create a short-lived crater. Until now, scientists have focused on the evolution of this underwater cavity, mainly for applications in energy harvesting. What happens above the water, and how a droplet’s crown-like shape evolves with the cavity below, remained less understood.

“The descriptions and understanding of what happens below the surface, and above, have remained very much divorced,” says Bourouiba, who believes such an understanding can help to predict how droplets launch and spread chemicals, particles, and microbes into the air.

Splash in 3D

To study the coupled dynamics between a droplet’s cavity and crown, the team set up an experiment to dispense water droplets into a deep pool. For the purposes of their study, the researchers considered a deep pool to be a body of water that is deep enough that a splashing droplet would remain far away from the pool’s bottom. In these terms, they found that a pool with a depth of at least 20 centimeters was sufficient for their experiments.

They varied each droplet’s size, with an average diameter of about 5 millimeters. They also dispensed droplets from various heights, causing the droplets to hit the pool’s surface at different speeds, which on average was about 5 meters per second. The overall dynamics, Bourouiba says, should be similar to what occurs on the surface of a puddle or pond during an average rainstorm.

“This is capturing the speed at which raindrops fall,” she says. “These wouldn’t be very small, misty drops. This would be rainstorm drops for which one needs an umbrella.”

Using high-speed imaging techniques inspired by Edgerton’s pioneering photography, the team captured videos of pool-splashing droplets, at rates of up to 12,500 frames per second. They then applied in-house imaging processing methods to extract key measurements from the image sequences, such as the changing width and depth of the underwater cavity, and the evolving diameter and height of the rising crown. The researchers also captured especially tricky measurements, of the crown’s wall thickness profile and inner flow — the cylinder that rises out of the pool, just before it forms a rim and points that are characteristic of a crown.

“This cylinder-like wall of rising liquid, and how it evolves in time and space, is at the heart of everything,” Bourouiba says. “It’s what connects the fluid from the pool to what will go into the rim and then be ejected into the air through smaller, secondary droplets.”

The researchers worked the image data into a set of “evolution equations,” or a mathematical model that relates the various properties of an impacting droplet, such as the width of its cavity and the thickness and speed profiles of its crown wall, and how these properties change over time, given a droplet’s starting size and impact speed.

“We now have a closed-form mathematical expression that people can use to see how all these quantities of a splashing droplet change over space and time,” says co-author Shen, who plans, with Bourouiba, to apply the new model to the behavior of secondary droplets and understanding how a splash end-up dispersing particles such as pathogens and pesticides. “This opens up the possibility to study all these problems of splash in 3D, with self-contained closed-formed equations, which was not possible before.”

This research was supported, in part, by the Department of Agriculture-National Institute of Food and Agriculture Specialty Crop Research Initiative; the Richard and Susan Smith Family Foundation; the National Science Foundation; the Centers for Disease Control and Prevention-National Institute for Occupational Safety and Health; Inditex; and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health.

As part of a multi-pronged approach toward curbing the effects of greenhouse gas emissions, scientists seek to better understand the impact of rising carbon dioxide (CO2) levels on terrestrial ecosystems, particularly tropical forests. To that end, climate scientist César Terrer, the Class of 1958 Career Development Assistant Professor of Civil and Environmental Engineering (CEE) at MIT, and colleague Josh Fisher of Chapman University are bringing their scientific minds to bear on a unique setting — an active volcano in Costa Rica — as a way to study carbon dioxide emissions and their influence. 

Elevated CO2 levels can lead to a phenomenon known as the CO2 fertilization effect, where plants grow more and absorb greater amounts of carbon, providing a cooling effect. While this effect has the potential to be a natural climate change mitigator, the extent of how much carbon plants can continue to absorb remains uncertain. There are growing concerns from scientists that plants may eventually reach a saturation point, losing their ability to offset increasing atmospheric CO2. Understanding these dynamics is crucial for accurate climate predictions and developing strategies to manage carbon sequestration. Here, Terrer discusses his innovative approach, his motivations for joining the project, and the importance of advancing this research.

Q: Why did you get involved in this line of research, and what makes it unique?

A: Josh Fisher, a climate scientist and long-time collaborator, had the brilliant idea to take advantage of naturally high CO2 levels near active volcanoes to study the fertilization effect in real-world conditions. Conducting such research in dense tropical forests like the Amazon — where the largest uncertainties about CO2 fertilization exist — is challenging. It would require large-scale CO2 tanks and extensive infrastructure to evenly distribute the gas throughout the towering trees and intricate canopy layers — a task that is not only logistically complex, but also highly costly. Our approach allows us to circumvent those obstacles and gather critical data in a way that hasn't been done before.

Josh was looking for an expert in the field of carbon ecology to co-lead and advance this research with him. My expertise of understanding the dynamics that regulate carbon storage in terrestrial ecosystems within the context of climate change made for a natural fit to co-lead and advance this research with him. This field has been central to my research, and was the focus of my PhD thesis.

Our experiments inside the Rincon de la Vieja National Park are particularly exciting because CO2 concentrations in the areas near the volcano are four times higher than the global average. This gives us a rare opportunity to observe how elevated CO2 affects plant biomass in a natural setting — something that has never been attempted at this scale.

Q: How are you measuring CO2 concentrations at the volcano?

A: We have installed a network of 50 sensors in the forest canopy surrounding the volcano. These sensors continuously monitor CO2 levels, allowing us to compare areas with naturally high CO2 emissions from the volcano to control areas with typical atmospheric CO2 concentrations. The sensors are Bluetooth-enabled, requiring us to be in close proximity to retrieve the data. They will remain in place for a full year, capturing a continuous dataset on CO2 fluctuations. Our next data collection trip is scheduled for March, with another planned a year after the initial deployment.

Q: What are the long-term goals of this research?

A: Our primary objective is to determine whether the CO2 fertilization effect can be sustained, or if plants will eventually reach a saturation point, limiting their ability to absorb additional carbon. Understanding this threshold is crucial for improving climate models and carbon mitigation strategies.

To expand the scope of our measurements, we are exploring the use of airborne technologies — such as drones or airplane-mounted sensors — to assess carbon storage across larger areas. This would provide a more comprehensive view of carbon sequestration potential in tropical ecosystems. Ultimately, this research could offer critical insights into the future role of forests in mitigating climate change, helping scientists and policymakers develop more accurate carbon budgets and climate projections. If successful, our approach could pave the way for similar studies in other ecosystems, deepening our understanding of how nature responds to rising CO2 levels.

All biological function is dependent on how different proteins interact with each other. Protein-protein interactions facilitate everything from transcribing DNA and controlling cell division to higher-level functions in complex organisms.

Much remains unclear, however, about how these functions are orchestrated on the molecular level, and how proteins interact with each other — either with other proteins or with copies of themselves.

Recent findings have revealed that small protein fragments have a lot of functional potential. Even though they are incomplete pieces, short stretches of amino acids can still bind to interfaces of a target protein, recapitulating native interactions. Through this process, they can alter that protein’s function or disrupt its interactions with other proteins.

Protein fragments could therefore empower both basic research on protein interactions and cellular processes, and could potentially have therapeutic applications.

Recently published in Proceedings of the National Academy of Sciences, a new method developed in the Department of Biology builds on existing artificial intelligence models to computationally predict protein fragments that can bind to and inhibit full-length proteins in E. coli. Theoretically, this tool could lead to genetically encodable inhibitors against any protein.

The work was done in the lab of associate professor of biology and Howard Hughes Medical Institute investigator Gene-Wei Li in collaboration with the lab of Jay A. Stein (1968) Professor of Biology, professor of biological engineering, and department head Amy Keating.

Leveraging machine learning

The program, called FragFold, leverages AlphaFold, an AI model that has led to phenomenal advancements in biology in recent years due to its ability to predict protein folding and protein interactions.

The goal of the project was to predict fragment inhibitors, which is a novel application of AlphaFold. The researchers on this project confirmed experimentally that more than half of FragFold’s predictions for binding or inhibition were accurate, even when researchers had no previous structural data on the mechanisms of those interactions.

“Our results suggest that this is a generalizable approach to find binding modes that are likely to inhibit protein function, including for novel protein targets, and you can use these predictions as a starting point for further experiments,” says co-first and corresponding author Andrew Savinov, a postdoc in the Li Lab. “We can really apply this to proteins without known functions, without known interactions, without even known structures, and we can put some credence in these models we’re developing.”

One example is FtsZ, a protein that is key for cell division. It is well-studied but contains a region that is intrinsically disordered and, therefore, especially challenging to study. Disordered proteins are dynamic, and their functional interactions are very likely fleeting — occurring so briefly that current structural biology tools can’t capture a single structure or interaction.

The researchers leveraged FragFold to explore the activity of fragments of FtsZ, including fragments of the intrinsically disordered region, to identify several new binding interactions with various proteins. This leap in understanding confirms and expands upon previous experiments measuring FtsZ’s biological activity.

This progress is significant in part because it was made without solving the disordered region’s structure, and because it exhibits the potential power of FragFold.

“This is one example of how AlphaFold is fundamentally changing how we can study molecular and cell biology,” Keating says. “Creative applications of AI methods, such as our work on FragFold, open up unexpected capabilities and new research directions.”

Inhibition, and beyond

The researchers accomplished these predictions by computationally fragmenting each protein and then modeling how those fragments would bind to interaction partners they thought were relevant.

They compared the maps of predicted binding across the entire sequence to the effects of those same fragments in living cells, determined using high-throughput experimental measurements in which millions of cells each produce one type of protein fragment.

AlphaFold uses co-evolutionary information to predict folding, and typically evaluates the evolutionary history of proteins using something called multiple sequence alignments for every single prediction run. The MSAs are critical, but are a bottleneck for large-scale predictions — they can take a prohibitive amount of time and computational power.

For FragFold, the researchers instead pre-calculated the MSA for a full-length protein once, and used that result to guide the predictions for each fragment of that full-length protein.

Savinov, together with Keating Lab alumnus Sebastian Swanson PhD ’23, predicted inhibitory fragments of a diverse set of proteins in addition to FtsZ. Among the interactions they explored was a complex between lipopolysaccharide transport proteins LptF and LptG. A protein fragment of LptG inhibited this interaction, presumably disrupting the delivery of lipopolysaccharide, which is a crucial component of the E. coli outer cell membrane essential for cellular fitness.

“The big surprise was that we can predict binding with such high accuracy and, in fact, often predict binding that corresponds to inhibition,” Savinov says. “For every protein we’ve looked at, we’ve been able to find inhibitors.”

The researchers initially focused on protein fragments as inhibitors because whether a fragment could block an essential function in cells is a relatively simple outcome to measure systematically. Looking forward, Savinov is also interested in exploring fragment function outside inhibition, such as fragments that can stabilize the protein they bind to, enhance or alter its function, or trigger protein degradation.

Design, in principle

This research is a starting point for developing a systemic understanding of cellular design principles, and what elements deep-learning models may be drawing on to make accurate predictions.

“There’s a broader, further-reaching goal that we’re building towards,” Savinov says. “Now that we can predict them, can we use the data we have from predictions and experiments to pull out the salient features to figure out what AlphaFold has actually learned about what makes a good inhibitor?”

Savinov and collaborators also delved further into how protein fragments bind, exploring other protein interactions and mutating specific residues to see how those interactions change how the fragment interacts with its target.

Experimentally examining the behavior of thousands of mutated fragments within cells, an approach known as deep mutational scanning, revealed key amino acids that are responsible for inhibition. In some cases, the mutated fragments were even more potent inhibitors than their natural, full-length sequences.

“Unlike previous methods, we are not limited to identifying fragments in experimental structural data,” says Swanson. “The core strength of this work is the interplay between high-throughput experimental inhibition data and the predicted structural models: the experimental data guides us towards the fragments that are particularly interesting, while the structural models predicted by FragFold provide a specific, testable hypothesis for how the fragments function on a molecular level.”

Savinov is excited about the future of this approach and its myriad applications.

“By creating compact, genetically encodable binders, FragFold opens a wide range of possibilities to manipulate protein function,” Li agrees. “We can imagine delivering functionalized fragments that can modify native proteins, change their subcellular localization, and even reprogram them to create new tools for studying cell biology and treating diseases.” 

Seven MIT faculty and 21 additional MIT alumni are among 126 early-career researchers honored with 2025 Sloan Research Fellowships by the Alfred P. Sloan Foundation.

The recipients represent the MIT departments of Biology; Chemistry; Civil and Environmental Engineering; Earth, Atmospheric and Planetary Sciences; Economics; Electrical Engineering and Computer Science; Mathematics; and Physics as well as the Music and Theater Arts Section and the MIT Sloan School of Management.

The fellowships honor exceptional researchers at U.S. and Canadian educational institutions, whose creativity, innovation, and research accomplishments make them stand out as the next generation of leaders. Winners receive a two-year, $75,000 fellowship that can be used flexibly to advance the fellow’s research.

“The Sloan Research Fellows represent the very best of early-career science, embodying the creativity, ambition, and rigor that drive discovery forward,” says Adam F. Falk, president of the Alfred P. Sloan Foundation. “These extraordinary scholars are already making significant contributions, and we are confident they will shape the future of their fields in remarkable ways.”

Including this year’s recipients, a total of 333 MIT faculty have received Sloan Research Fellowships since the program’s inception in 1955. MIT and Northwestern University are tied for having the most faculty in the 2025 cohort of fellows, each with seven. The MIT recipients are: 

Ariel L. Furst is the Paul M. Cook Career Development Professor of Chemical Engineering at MIT. Her lab combines biological, chemical, and materials engineering to solve challenges in human health and environmental sustainability, with lab members developing technologies for implementation in low-resource settings to ensure equitable access to technology. Furst completed her PhD in the lab of Professor Jacqueline K. Barton at Caltech developing new cancer diagnostic strategies based on DNA charge transport. She was then an A.O. Beckman Postdoctoral Fellow in the lab of Professor Matthew Francis at the University of California at Berkeley, developing sensors to monitor environmental pollutants. She is the recipient of the NIH New Innovator Award, the NSF CAREER Award, and the Dreyfus Teacher-Scholar Award. She is passionate about STEM outreach and increasing participation of underrepresented groups in engineering.

Mohsen Ghaffari SM ’13, PhD ’17 is an associate professor in the Department of Electrical Engineering and Computer Science (EECS) as well as the Computer Science and Artificial Intelligence Laboratory (CSAIL). His research explores the theory of distributed and parallel computation, and he has had influential work on a range of algorithmic problems, including generic derandomization methods for distributed computing and parallel computing (which resolved several decades-old open problems), improved distributed algorithms for graph problems, sublinear algorithms derived via distributed techniques, and algorithmic and impossibility results for massively parallel computation. His work has been recognized with best paper awards at the IEEE Symposium on Foundations of Computer Science (FOCS), ACM-SIAM Symposium on Discrete Algorithms (SODA), ACM Symposium on Parallelism in Algorithms and Architectures (SPAA), the ACM Symposium on Principles of Distributed Computing (PODC), and the International Symposium on Distributed Computing (DISC), the European Research Council's Starting Grant, and a Google Faculty Research Award, among others.

Marzyeh Ghassemi PhD ’17 is an associate professor within EECS and the Institute for Medical Engineering and Science (IMES). Ghassemi earned two bachelor’s degrees in computer science and electrical engineering from New Mexico State University as a Goldwater Scholar; her MS in biomedical engineering from Oxford University as a Marshall Scholar; and her PhD in computer science from MIT. Following stints as a visiting researcher with Alphabet’s Verily and an assistant professor at University of Toronto, Ghassemi joined EECS and IMES as an assistant professor in July 2021. (IMES is the home of the Harvard-MIT Program in Health Sciences and Technology.) She is affiliated with the Laboratory for Information and Decision Systems (LIDS), the MIT-IBM Watson AI Lab, the Abdul Latif Jameel Clinic for Machine Learning in Health, the Institute for Data, Systems, and Society (IDSS), and CSAIL. Ghassemi’s research in the Healthy ML Group creates a rigorous quantitative framework in which to design, develop, and place machine learning models in a way that is robust and useful, focusing on health settings. Her contributions range from socially-aware model construction to improving subgroup- and shift-robust learning methods to identifying important insights in model deployment scenarios that have implications in policy, health practice, and equity. Among other awards, Ghassemi has been named one of MIT Technology Review’s 35 Innovators Under 35 and an AI2050 Fellow, as well as receiving the 2018 Seth J. Teller Award, the 2023 MIT Prize for Open Data, a 2024 NSF CAREER Award, and the Google Research Scholar Award. She founded the nonprofit Association for Health, Inference and Learning (AHLI) and her work has been featured in popular press such as Forbes, Fortune, MIT News, and The Huffington Post.

Darcy McRose is the Thomas D. and Virginia W. Cabot Career Development Assistant Professor of Civil and Environmental Engineering. She is an environmental microbiologist who draws on techniques from genetics, chemistry, and geosciences to understand the ways microbes control nutrient cycling and plant health. Her laboratory uses small molecules, or “secondary metabolites,” made by plants and microbes as tractable experiments tools to study microbial activity in complex environments like soils and sediments. In the long term, this work aims to uncover fundamental controls on microbial physiology and community assembly that can be used to promote agricultural sustainability, ecosystem health, and human prosperity.

Sarah Millholland, an assistant professor of physics at MIT and member of the Kavli Institute for Astrophysics and Space Research, is a theoretical astrophysicist who studies extrasolar planets, including their formation and evolution, orbital dynamics, and interiors/atmospheres. She studies patterns in the observed planetary orbital architectures, referring to properties like the spacings, eccentricities, inclinations, axial tilts, and planetary size relationships. She specializes in investigating how gravitational interactions such as tides, resonances, and spin dynamics sculpt observable exoplanet properties. She is the 2024 recipient of the Vera Rubin Early Career Award for her contributions to the formation and dynamics of extrasolar planetary systems. She plans to use her Sloan Fellowship to explore how tidal physics shape the diversity of orbits and interiors of exoplanets orbiting close to their stars.

Emil Verner is the Albert F. (1942) and Jeanne P. Clear Career Development Associate Professor of Global Management and an associate professor of finance at the MIT Sloan School of Management. His research lies at the intersection of finance and macroeconomics, with a particular focus on understanding the causes and consequences of financial crises over the past 150 years. Verner’s recent work examines the drivers of bank runs and insolvency during banking crises, the role of debt booms in amplifying macroeconomic fluctuations, the effectiveness of debt relief policies during crises, and how financial crises impact political polarization and support for populist parties. Before joining MIT, he earned a PhD in economics from Princeton University.

Christian Wolf, the Rudi Dornbusch Career Development Assistant Professor of Economics and a faculty research fellow at the National Bureau of Economic Research, works in macroeconomics, monetary economics, and time series econometrics. His work focuses on the development and application of new empirical methods to address classic macroeconomic questions and to evaluate how robust the answers are to a range of common modeling assumptions. His research has provided path-breaking insights on monetary transmission mechanisms and fiscal policy. In a separate strand of work, Wolf has substantially deepened our understanding of the appropriate methods macroeconomists should use to estimate impulse response functions — how key economic variables respond to policy changes or unexpected shocks.

The following MIT alumni also received fellowships: 

Jason Altschuler SM ’18, PhD ’22
David Bau III PhD ’21 
Rene Boiteau PhD ’16 
Lynne Chantranupong PhD ’17
Lydia B. Chilton ’06, ’07, MNG ’09 
Jordan Cotler ’15 
Alexander Ji PhD ’17 
Sarah B. King ’10
Allison Z. Koenecke ’14 
Eric Larson PhD ’18
Chen Lian ’15, PhD ’20
Huanqian Loh ’06 
Ian J. Moult PhD ’16
Lisa Olshansky PhD ’15
Andrew Owens SM ’13, PhD ’16 
Matthew Rognlie PhD ’16
David Rolnick ’12, PhD ’18 
Shreya Saxena PhD ’17
Mark Sellke ’18
Amy X. Zhang PhD ’19 
Aleksandr V. Zhukhovitskiy PhD ’16

Longtime MIT Professor Anthony “Tony” Sinskey ScD ’67, who was also the co-founder and faculty director of the Center for Biomedical Innovation (CBI), passed away on Feb. 12 at his home in New Hampshire. He was 84.

Deeply engaged with MIT, Sinskey left his mark on the Institute as much through the relationships he built as the research he conducted. Colleagues say that throughout his decades on the faculty, Sinskey’s door was always open.

“He was incredibly generous in so many ways,” says Graham Walker, an American Cancer Society Professor at MIT. “He was so willing to support people, and he did it out of sheer love and commitment. If you could just watch Tony in action, there was so much that was charming about the way he lived. I’ve said for years that after they made Tony, they broke the mold. He was truly one of a kind.”

Sinskey’s lab at MIT explored methods for metabolic engineering and the production of biomolecules. Over the course of his research career, he published more than 350 papers in leading peer-reviewed journals for biology, metabolic engineering, and biopolymer engineering, and filed more than 50 patents. Well-known in the biopharmaceutical industry, Sinskey contributed to the founding of multiple companies, including Metabolix, Tepha, Merrimack Pharmaceuticals, and Genzyme Corporation. Sinskey’s work with CBI also led to impactful research papers, manufacturing initiatives, and educational content since its founding in 2005.

Across all of his work, Sinskey built a reputation as a supportive, collaborative, and highly entertaining friend who seemed to have a story for everything.

“Tony would always ask for my opinions — what did I think?” says Barbara Imperiali, MIT’s Class of 1922 Professor of Biology and Chemistry, who first met Sinskey as a graduate student. “Even though I was younger, he viewed me as an equal. It was exciting to be able to share my academic journey with him. Even later, he was continually opening doors for me, mentoring, connecting. He felt it was his job to get people into a room together to make new connections.”

Sinskey grew up in the small town of Collinsville, Illinois, and spent nights after school working on a farm. For his undergraduate degree, he attended the University of Illinois, where he got a job washing dishes at the dining hall. One day, as he recalled in a 2020 conversation, he complained to his advisor about the dishwashing job, so the advisor offered him a job washing equipment in his microbiology lab.

In a development that would repeat itself throughout Sinskey’s career, he befriended the researchers in the lab and started learning about their work. Soon he was showing up on weekends and helping out. The experience inspired Sinskey to go to graduate school, and he only applied to one place.

Sinskey earned his ScD from MIT in nutrition and food science in 1967. He joined MIT’s faculty a few years later and never left.

“He loved MIT and its excellence in research and education, which were incredibly important to him,” Walker says. “I don’t know of another institution this interdisciplinary — there’s barely a speed bump between departments — so you can collaborate with anybody. He loved that. He also loved the spirit of entrepreneurship, which he thrived on. If you heard somebody wanted to get a project done, you could run around, get 10 people, and put it together. He just loved doing stuff like that.”

Working across departments would become a signature of Sinskey’s research. His original office was on the first floor of MIT’s Building 56, right next to the parking lot, so he’d leave his door open in the mornings and afternoons and colleagues would stop in and chat.

“One of my favorite things to do was to drop in on Tony when I saw that his office door was open,” says Chris Kaiser, MIT’s Amgen Professor of Biology. “We had a whole range of things we liked to catch up on, but they always included his perspectives looking back on his long history at MIT. It also always included hopes for the future, including tracking trajectories of MIT students, whom he doted on.”

Long before the internet, colleagues describe Sinskey as a kind of internet unto himself, constantly leveraging his vast web of relationships to make connections and stay on top of the latest science news.

“He was an incredibly gracious person — and he knew everyone,” Imperiali says. “It was as if his Rolodex had no end. You would sit there and he would say, ‘Call this person.’ or ‘Call that person.’ And ‘Did you read this new article?’ He had a wonderful view of science and collaboration, and he always made that a cornerstone of what he did. Whenever I’d see his door open, I’d grab a cup of tea and just sit there and talk to him.”

When the first recombinant DNA molecules were produced in the 1970s, it became a hot area of research. Sinskey wanted to learn more about recombinant DNA, so he hosted a large symposium on the topic at MIT that brought in experts from around the world.

“He got his name associated with recombinant DNA for years because of that,” Walker recalls. “People started seeing him as Mr. Recombinant DNA. That kind of thing happened all the time with Tony.”

Sinskey’s research contributions extended beyond recombinant DNA into other microbial techniques to produce amino acids and biodegradable plastics. He co-founded CBI in 2005 to improve global health through the development and dispersion of biomedical innovations. The center adopted Sinskey’s collaborative approach in order to accelerate innovation in biotechnology and biomedical research, bringing together experts from across MIT’s schools.

“Tony was at the forefront of advancing cell culture engineering principles so that making biomedicines could become a reality. He knew early on that biomanufacturing was an important step on the critical path from discovering a drug to delivering it to a patient,” says Stacy Springs, the executive director of CBI. “Tony was not only my boss and mentor, but one of my closest friends. He was always working to help everyone reach their potential, whether that was a colleague, a former or current researcher, or a student. He had a gentle way of encouraging you to do your best.”

“MIT is one of the greatest places to be because you can do anything you want here as long as it’s not a crime,” Sinskey joked in 2020. “You can do science, you can teach, you can interact with people — and the faculty at MIT are spectacular to interact with.”

Sinskey shared his affection for MIT with his family. His wife, the late ChoKyun Rha ’62, SM ’64, SM ’66, ScD ’67, was a professor at MIT for more than four decades and the first woman of Asian descent to receive tenure at MIT. His two sons also attended MIT — Tong-ik Lee Sinskey ’79, SM ’80 and Taeminn Song MBA ’95, who is the director of strategy and strategic initiatives for MIT Information Systems and Technology (IS&T).

Song recalls: “He was driven by same goal my mother had: to advance knowledge in science and technology by exploring new ideas and pushing everyone around them to be better.”

Around 10 years ago, Sinskey began teaching a class with Walker, Course 7.21/7.62 (Microbial Physiology). Walker says their approach was to treat the students as equals and learn as much from them as they taught. The lessons extended beyond the inner workings of microbes to what it takes to be a good scientist and how to be creative. Sinskey and Rha even started inviting the class over to their home for Thanksgiving dinner each year.

“At some point, we realized the class was turning into a close community,” Walker says. “Tony had this endless supply of stories. It didn’t seem like there was a topic in biology that Tony didn’t have a story about either starting a company or working with somebody who started a company.”

Over the last few years, Walker wasn’t sure they were going to continue teaching the class, but Sinskey remarked it was one of the things that gave his life meaning after his wife’s passing in 2021. That decided it.

After finishing up this past semester with a class-wide lunch at Legal Sea Foods, Sinskey and Walker agreed it was one of the best semesters they’d ever taught.

In addition to his two sons, Sinskey is survived by his daughter-in-law Hyunmee Elaine Song, five grandchildren, and two great grandsons. He has two brothers, Terry Sinskey (deceased in 1975) and Timothy Sinskey, and a sister, Christine Sinskey Braudis.

Gifts in Sinskey’s memory can be made to the ChoKyun Rha (1962) and Anthony J Sinskey (1967) Fund.

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don’t code for proteins, called introns, are cut out and the coding portions are spliced back together.

This process is controlled by a large protein-RNA complex called the spliceosome. MIT biologists have now discovered a new layer of regulation that helps to determine which sites on the messenger RNA molecule the spliceosome will target.

The research team discovered that this type of regulation, which appears to influence the expression of about half of all human genes, is found throughout the animal kingdom, as well as in plants. The findings suggest that the control of RNA splicing, a process that is fundamental to gene expression, is more complex than previously known.

“Splicing in more complex organisms, like humans, is more complicated than it is in some model organisms like yeast, even though it’s a very conserved molecular process. There are bells and whistles on the human spliceosome that allow it to process specific introns more efficiently. One of the advantages of a system like this may be that it allows more complex types of gene regulation,” says Connor Kenny, an MIT graduate student and the lead author of the study.

Christopher Burge, the Uncas and Helen Whitaker Professor of Biology at MIT, is the senior author of the study, which appears today in Nature Communications.

Building proteins

RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

Each mRNA transcript contains coding regions, known as exons, and noncoding regions, known as introns. They also include sites that act as signals for where splicing should occur, allowing the cell to assemble the correct sequence for a desired protein. This process enables a single gene to produce multiple proteins; over evolutionary timescales, splicing can also change the size and content of genes and proteins, when different exons become included or excluded.

The spliceosome, which forms on introns, is composed of proteins and noncoding RNAs called small nuclear RNAs (snRNAs). In the first step of spliceosome assembly, an snRNA molecule known as U1 snRNA binds to the 5’ splice site at the beginning of the intron. Until now, it had been thought that the binding strength between the 5’ splice site and the U1 snRNA was the most important determinant of whether an intron would be spliced out of the mRNA transcript.

In the new study, the MIT team discovered that a family of proteins called LUC7 also helps to determine whether splicing will occur, but only for a subset of introns — in human cells, up to 50 percent.

Before this study, it was known that LUC7 proteins associate with U1 snRNA, but the exact function wasn’t clear. There are three different LUC7 proteins in human cells, and Kenny’s experiments revealed that two of these proteins interact specifically with one type of 5’ splice site, which the researchers called “right-handed.” A third human LUC7 protein interacts with a different type, which the researchers call “left-handed.”

The researchers found that about half of human introns contain a right- or left-handed site, while the other half do not appear to be controlled by interaction with LUC7 proteins. This type of control appears to add another layer of regulation that helps remove specific introns more efficiently, the researchers say.

“The paper shows that these two different 5’ splice site subclasses exist and can be regulated independently of one another,” Kenny says. “Some of these core splicing processes are actually more complex than we previously appreciated, which warrants more careful examination of what we believe to be true about these highly conserved molecular processes.”

“Complex splicing machinery”

Previous work has shown that mutation or deletion of one of the LUC7 proteins that bind to right-handed splice sites is linked to blood cancers, including about 10 percent of acute myeloid leukemias (AMLs). In this study, the researchers found that AMLs that lost a copy of the LUC7L2 gene have inefficient splicing of right-handed splice sites. These cancers also developed the same type of altered metabolism seen in earlier work.

“Understanding how the loss of this LUC7 protein in some AMLs alters splicing could help in the design of therapies that exploit these splicing differences to treat AML,” Burge says. “There are also small molecule drugs for other diseases such as spinal muscular atrophy that stabilize the interaction between U1 snRNA and specific 5’ splice sites. So the knowledge that particular LUC7 proteins influence these interactions at specific splice sites could aid in improving the specificity of this class of small molecules.”

Working with a lab led by Sascha Laubinger, a professor at Martin Luther University Halle-Wittenberg, the researchers found that introns in plants also have right- and left-handed 5’ splice sites that are regulated by Luc7 proteins.

The researchers’ analysis suggests that this type of splicing arose in a common ancestor of plants, animals, and fungi, but it was lost from fungi soon after they diverged from plants and animals.

“A lot what we know about how splicing works and what are the core components actually comes from relatively old yeast genetics work,” Kenny says. “What we see is that humans and plants tend to have more complex splicing machinery, with additional components that can regulate different introns independently.”

The researchers now plan to further analyze the structures formed by the interactions of Luc7 proteins with mRNA and the rest of the spliceosome, which could help them figure out in more detail how different forms of Luc7 bind to different 5’ splice sites.

The research was funded by the U.S. National Institutes of Health and the German Research Foundation.

There’s a lot of untapped potential in our homes and vehicles that could be harnessed to reinforce local power grids and make them more resilient to unforeseen outages, a new study shows.

In response to a cyber attack or natural disaster, a backup network of decentralized devices — such as residential solar panels, batteries, electric vehicles, heat pumps, and water heaters — could restore electricity or relieve stress on the grid, MIT engineers say.

Such devices are “grid-edge” resources found close to the consumer rather than near central power plants, substations, or transmission lines. Grid-edge devices can independently generate, store, or tune their consumption of power. In their study, the research team shows how such devices could one day be called upon to either pump power into the grid, or rebalance it by dialing down or delaying their power use.

In a paper appearing this week in the Proceedings of the National Academy of Sciences, the engineers present a blueprint for how grid-edge devices could reinforce the power grid through a “local electricity market.” Owners of grid-edge devices could subscribe to a regional market and essentially loan out their device to be part of a microgrid or a local network of on-call energy resources.

In the event that the main power grid is compromised, an algorithm developed by the researchers would kick in for each local electricity market, to quickly determine which devices in the network are trustworthy. The algorithm would then identify the combination of trustworthy devices that would most effectively mitigate the power failure, by either pumping power into the grid or reducing the power they draw from it, by an amount that the algorithm would calculate and communicate to the relevant subscribers. The subscribers could then be compensated through the market, depending on their participation.

The team illustrated this new framework through a number of grid attack scenarios, in which they considered failures at different levels of a power grid, from various sources such as a cyber attack or a natural disaster. Applying their algorithm, they showed that various networks of grid-edge devices were able to dissolve the various attacks.

The results demonstrate that grid-edge devices such as rooftop solar panels, EV chargers, batteries, and smart thermostats (for HVAC devices or heat pumps) could be tapped to stabilize the power grid in the event of an attack.

“All these small devices can do their little bit in terms of adjusting their consumption,” says study co-author Anu Annaswamy, a research scientist in MIT’s Department of Mechanical Engineering. “If we can harness our smart dishwashers, rooftop panels, and EVs, and put our combined shoulders to the wheel, we can really have a resilient grid.”

The study’s MIT co-authors include lead author Vineet Nair and John Williams, along with collaborators from multiple institutions including the Indian Institute of Technology, the National Renewable Energy Laboratory, and elsewhere.

Power boost

The team’s study is an extension of their broader work in adaptive control theory and designing systems to automatically adapt to changing conditions. Annaswamy, who leads the Active-Adaptive Control Laboratory at MIT, explores ways to boost the reliability of renewable energy sources such as solar power.

“These renewables come with a strong temporal signature, in that we know for sure the sun will set every day, so the solar power will go away,” Annaswamy says. “How do you make up for the shortfall?”

The researchers found the answer could lie in the many grid-edge devices that consumers are increasingly installing in their own homes.

“There are lots of distributed energy resources that are coming up now, closer to the customer rather than near large power plants, and it’s mainly because of individual efforts to decarbonize,” Nair says. “So you have all this capability at the grid edge. Surely we should be able to put them to good use.”

While considering ways to deal with drops in energy from the normal operation of renewable sources, the team also began to look into other causes of power dips, such as from cyber attacks. They wondered, in these malicious instances, whether and how the same grid-edge devices could step in to stabilize the grid following an unforeseen, targeted attack.

Attack mode

In their new work, Annaswamy, Nair, and their colleagues developed a framework for incorporating grid-edge devices, and in particular, internet-of-things (IoT) devices, in a way that would support the larger grid in the event of an attack or disruption. IoT devices are physical objects that contain sensors and software that connect to the internet.

For their new framework, named EUREICA (Efficient, Ultra-REsilient, IoT-Coordinated Assets), the researchers start with the assumption that one day, most grid-edge devices will also be IoT devices, enabling rooftop panels, EV chargers, and smart thermostats to wirelessly connect to a larger network of similarly independent and distributed devices. 

The team envisions that for a given region, such as a community of 1,000 homes, there exists a certain number of IoT devices that could potentially be enlisted in the region’s local network, or microgrid. Such a network would be managed by an operator, who would be able to communicate with operators of other nearby microgrids.

If the main power grid is compromised or attacked, operators would run the researchers’ decision-making algorithm to determine trustworthy devices within the network that can pitch in to help mitigate the attack.

The team tested the algorithm on a number of scenarios, such as a cyber attack in which all smart thermostats made by a certain manufacturer are hacked to raise their setpoints simultaneously to a degree that dramatically alters a region’s energy load and destabilizes the grid. The researchers also considered attacks and weather events that would shut off the transmission of energy at various levels and nodes throughout a power grid.

“In our attacks we consider between 5 and 40 percent of the power being lost. We assume some nodes are attacked, and some are still available and have some IoT resources, whether a battery with energy available or an EV or HVAC device that’s controllable,” Nair explains. “So, our algorithm decides which of those houses can step in to either provide extra power generation to inject into the grid or reduce their demand to meet the shortfall.”

In every scenario that they tested, the team found that the algorithm was able to successfully restabilize the grid and mitigate the attack or power failure. They acknowledge that to put in place such a network of grid-edge devices will require buy-in from customers, policymakers, and local officials, as well as innovations such as advanced power inverters that enable EVs to inject power back into the grid.

“This is just the first of many steps that have to happen in quick succession for this idea of local electricity markets to be implemented and expanded upon,” Annaswamy says. “But we believe it’s a good start.”

This work was supported, in part, by the U.S. Department of Energy and the MIT Energy Initiative.

The use of terahertz waves, which have shorter wavelengths and higher frequencies than radio waves, could enable faster data transmission, more precise medical imaging, and higher-resolution radar.

But effectively generating terahertz waves using a semiconductor chip, which is essential for incorporation into electronic devices, is notoriously difficult.

Many current techniques can’t generate waves with enough radiating power for useful applications unless they utilize bulky and expensive silicon lenses. Higher radiating power allows terahertz signals to travel farther. Such lenses, which are often larger than the chip itself, make it hard to integrate the terahertz source into an electronic device.

To overcome these limitations, MIT researchers developed a terahertz amplifier-multiplier system that achieves higher radiating power than existing devices without the need for silicon lenses.

By affixing a thin, patterned sheet of material to the back of the chip and utilizing higher-power Intel transistors, the researchers produced a more efficient, yet scalable, chip-based terahertz wave generator.

This compact chip could be used to make terahertz arrays for applications like improved security scanners for detecting hidden objects or environmental monitors for pinpointing airborne pollutants.

“To take full advantage of a terahertz wave source, we need it to be scalable. A terahertz array might have hundreds of chips, and there is no place to put silicon lenses because the chips are combined with such high density. We need a different package, and here we’ve demonstrated a promising approach that can be used for scalable, low-cost terahertz arrays,” says Jinchen Wang, a graduate student in the Department of Electrical Engineering and Computer Science (EECS) and lead author of a paper on the terahertz radiator.

He is joined on the paper by EECS graduate students Daniel Sheen and Xibi Chen; Steven F. Nagle, managing director of the T.J. Rodgers RLE Laboratory; and senior author Ruonan Han, an associate professor in EECS, who leads the Terahertz Integrated Electronics Group. The research will be presented at the IEEE International Solid-States Circuits Conference.

Making waves

Terahertz waves sit on the electromagnetic spectrum between radio waves and infrared light. Their higher frequencies enable them to carry more information per second than radio waves, while they can safely penetrate a wider range of materials than infrared light.

One way to generate terahertz waves is with a CMOS chip-based amplifier-multiplier chain that increases the frequency of radio waves until they reach the terahertz range. To achieve the best performance, waves go through the silicon chip and are eventually emitted out the back into the open air.

But a property known as the dielectric constant gets in the way of a smooth transmission.

The dielectric constant influences how electromagnetic waves interact with a material. It affects the amount of radiation that is absorbed, reflected, or transmitted. Because the dielectric constant of silicon is much higher than that of air, most terahertz waves are reflected at the silicon-air boundary rather than being cleanly transmitted out the back.

Since most signal strength is lost at this boundary, current approaches often use silicon lenses to boost the power of the remaining signal. 

The MIT researchers approached this problem differently.

They drew on an electromechanical theory known as matching. With matching, they seek to equal out the dielectric constants of silicon and air, which will minimize the amount of signal that is reflected at the boundary.

They accomplish this by sticking a thin sheet of material which has a dielectric constant between silicon and air to the back of the chip. With this matching sheet in place, most waves will be transmitted out the back rather than being reflected.

A scalable approach

They chose a low-cost, commercially available substrate material with a dielectric constant very close to what they needed for matching. To improve performance, they used a laser cutter to punch tiny holes into the sheet until its dielectric constant was exactly right.

“Since the dielectric constant of air is 1, if you just cut some subwavelength holes in the sheet, it is equivalent to injecting some air, which lowers the overall dielectric constant of the matching sheet,” Wang explains.

In addition, they designed their chip with special transistors developed by Intel that have a higher maximum frequency and breakdown voltage than traditional CMOS transistors.

“These two things taken together, the more powerful transistors and the dielectric sheet, plus a few other small innovations, enabled us to outperform several other devices,” he says.

Their chip generated terahertz signals with a peak radiation power of 11.1 decibel-milliwatts, the best among state-of-the-art techniques. Moreover, since the low-cost chip can be fabricated at scale, it could be integrated into real-world electronic devices more readily.

One of the biggest challenges of developing a scalable chip was determining how to manage the power and temperature when generating terahertz waves.

“Because the frequency and the power are so high, many of the standard ways to design a CMOS chip are not applicable here,” Wang says.

The researchers also needed to devise a technique for installing the matching sheet that could be scaled up in a manufacturing facility.

Moving forward, they want to demonstrate this scalability by fabricating a phased array of CMOS terahertz sources, enabling them to steer and focus a powerful terahertz beam with a low-cost, compact device.

This research is supported, in part, by NASA’s Jet Propulsion Laboratory and Strategic University Research Partnerships Program, as well as the MIT Center for Integrated Circuits and Systems. The chip was fabricated through the Intel University Shuttle Program.

In the race to reduce climate-warming carbon emissions, the buildings sector is falling behind. While carbon dioxide (CO2) emissions in the U.S. electric power sector dropped by 34 percent between 2005 and 2021, emissions in the building sector declined by only 18 percent in that same time period. Moreover, in extremely cold locations, burning natural gas to heat houses can make up a substantial share of the emissions portfolio. Therefore, steps to electrify buildings in general, and residential heating in particular, are essential for decarbonizing the U.S. energy system.

But that change will increase demand for electricity and decrease demand for natural gas. What will be the net impact of those two changes on carbon emissions and on the cost of decarbonizing? And how will the electric power and natural gas sectors handle the new challenges involved in their long-term planning for future operations and infrastructure investments?

A new study by MIT researchers with support from the MIT Energy Initiative (MITEI) Future Energy Systems Center unravels the impacts of various levels of electrification of residential space heating on the joint power and natural gas systems. A specially devised modeling framework enabled them to estimate not only the added costs and emissions for the power sector to meet the new demand, but also any changes in costs and emissions that result for the natural gas sector.

The analyses brought some surprising outcomes. For example, they show that — under certain conditions — switching 80 percent of homes to heating by electricity could cut carbon emissions and at the same time significantly reduce costs over the combined natural gas and electric power sectors relative to the case in which there is only modest switching. That outcome depends on two changes: Consumers must install high-efficiency heat pumps plus take steps to prevent heat losses from their homes, and planners in the power and the natural gas sectors must work together as they make long-term infrastructure and operations decisions. Based on their findings, the researchers stress the need for strong state, regional, and national policies that encourage and support the steps that homeowners and industry planners can take to help decarbonize today’s building sector.

A two-part modeling approach

To analyze the impacts of electrification of residential heating on costs and emissions in the combined power and gas sectors, a team of MIT experts in building technology, power systems modeling, optimization techniques, and more developed a two-part modeling framework. Team members included Rahman Khorramfar, a senior postdoc in MITEI and the Laboratory for Information and Decision Systems (LIDS); Morgan Santoni-Colvin SM ’23, a former MITEI graduate research assistant, now an associate at Energy and Environmental Economics, Inc.; Saurabh Amin, a professor in the Department of Civil and Environmental Engineering and principal investigator in LIDS; Audun Botterud, a principal research scientist in LIDS; Leslie Norford, a professor in the Department of Architecture; and Dharik Mallapragada, a former MITEI principal research scientist, now an assistant professor at New York University, who led the project. They describe their new methods and findings in a paper published in the journal Cell Reports Sustainability on Feb. 6.

The first model in the framework quantifies how various levels of electrification will change end-use demand for electricity and for natural gas, and the impacts of possible energy-saving measures that homeowners can take to help. “To perform that analysis, we built a ‘bottom-up’ model — meaning that it looks at electricity and gas consumption of individual buildings and then aggregates their consumption to get an overall demand for power and for gas,” explains Khorramfar. By assuming a wide range of building “archetypes” — that is, groupings of buildings with similar physical characteristics and properties — coupled with trends in population growth, the team could explore how demand for electricity and for natural gas would change under each of five assumed electrification pathways: “business as usual” with modest electrification, medium electrification (about 60 percent of homes are electrified), high electrification (about 80 percent of homes make the change), and medium and high electrification with “envelope improvements,” such as sealing up heat leaks and adding insulation.

The second part of the framework consists of a model that takes the demand results from the first model as inputs and “co-optimizes” the overall electricity and natural gas system to minimize annual investment and operating costs while adhering to any constraints, such as limits on emissions or on resource availability. The modeling framework thus enables the researchers to explore the impact of each electrification pathway on the infrastructure and operating costs of the two interacting sectors.

The New England case study: A challenge for electrification

As a case study, the researchers chose New England, a region where the weather is sometimes extremely cold and where burning natural gas to heat houses contributes significantly to overall emissions. “Critics will say that electrification is never going to happen [in New England]. It’s just too expensive,” comments Santoni-Colvin. But he notes that most studies focus on the electricity sector in isolation. The new framework considers the joint operation of the two sectors and then quantifies their respective costs and emissions. “We know that electrification will require large investments in the electricity infrastructure,” says Santoni-Colvin. “But what hasn’t been well quantified in the literature is the savings that we generate on the natural gas side by doing that — so, the system-level savings.”

Using their framework, the MIT team performed model runs aimed at an 80 percent reduction in building-sector emissions relative to 1990 levels — a target consistent with regional policy goals for 2050. The researchers defined parameters including details about building archetypes, the regional electric power system, existing and potential renewable generating systems, battery storage, availability of natural gas, and other key factors describing New England.

They then performed analyses assuming various scenarios with different mixes of home improvements. While most studies assume typical weather, they instead developed 20 projections of annual weather data based on historical weather patterns and adjusted for the effects of climate change through 2050. They then analyzed their five levels of electrification.

Relative to business-as-usual projections, results from the framework showed that high electrification of residential heating could more than double the demand for electricity during peak periods and increase overall electricity demand by close to 60 percent. Assuming that building-envelope improvements are deployed in parallel with electrification reduces the magnitude and weather sensitivity of peak loads and creates overall efficiency gains that reduce the combined demand for electricity plus natural gas for home heating by up to 30 percent relative to the present day. Notably, a combination of high electrification and envelope improvements resulted in the lowest average cost for the overall electric power-natural gas system in 2050.

Lessons learned

Replacing existing natural gas-burning furnaces and boilers with heat pumps reduces overall energy consumption. Santoni-Colvin calls it “something of an intuitive result” that could be expected because heat pumps are “just that much more efficient than old, fossil fuel-burning systems. But even so, we were surprised by the gains.”

Other unexpected results include the importance of homeowners making more traditional energy efficiency improvements, such as adding insulation and sealing air leaks — steps supported by recent rebate policies. Those changes are critical to reducing costs that would otherwise be incurred for upgrading the electricity grid to accommodate the increased demand. “You can’t just go wild dropping heat pumps into everybody’s houses if you’re not also considering other ways to reduce peak loads. So it really requires an ‘all of the above’ approach to get to the most cost-effective outcome,” says Santoni-Colvin.

Testing a range of weather outcomes also provided important insights. Demand for heating fuel is very weather-dependent, yet most studies are based on a limited set of weather data — often a “typical year.” The researchers found that electrification can lead to extended peak electric load events that can last for a few days during cold winters. Accordingly, the researchers conclude that there will be a continuing need for a “firm, dispatchable” source of electricity; that is, a power-generating system that can be relied on to produce power any time it’s needed — unlike solar and wind systems. As examples, they modeled some possible technologies, including power plants fired by a low-carbon fuel or by natural gas equipped with carbon capture equipment. But they point out that there’s no way of knowing what types of firm generators will be available in 2050. It could be a system that’s not yet mature, or perhaps doesn’t even exist today.

In presenting their findings, the researchers note several caveats. For one thing, their analyses don’t include the estimated cost to homeowners of installing heat pumps. While that cost is widely discussed and debated, that issue is outside the scope of their current project.

In addition, the study doesn’t specify what happens to existing natural gas pipelines. “Some homes are going to electrify and get off the gas system and not have to pay for it, leaving other homes with increasing rates because the gas system cost now has to be divided among fewer customers,” says Khorramfar. “That will inevitably raise equity questions that need to be addressed by policymakers.”

Finally, the researchers note that policies are needed to drive residential electrification. Current financial support for installation of heat pumps and steps to make homes more thermally efficient are a good start. But such incentives must be coupled with a new approach to planning energy infrastructure investments. Traditionally, electric power planning and natural gas planning are performed separately. However, to decarbonize residential heating, the two sectors should coordinate when planning future operations and infrastructure needs. Results from the MIT analysis indicate that such cooperation could significantly reduce both emissions and costs for residential heating — a change that would yield a much-needed step toward decarbonizing the buildings sector as a whole.

MIT’s Abdul Latif Jameel Water and Food Systems Lab (J-WAFS) has transformed the landscape of water and food research at MIT, driving faculty engagement and catalyzing new research and innovation in these critical areas. With philanthropic, corporate, and government support, J-WAFS’ strategic approach spans the entire research life cycle, from support for early-stage research to commercialization grants for more advanced projects.

Over the past decade, J-WAFS has invested approximately $25 million in direct research funding to support MIT faculty pursuing transformative research with the potential for significant impact. “Since awarding our first cohort of seed grants in 2015, it’s remarkable to look back and see that over 10 percent of the MIT faculty have benefited from J-WAFS funding,” observes J-WAFS Executive Director Renee J. Robins ’83. “Many of these professors hadn’t worked on water or food challenges before their first J-WAFS grant.” 

By fostering interdisciplinary collaborations and supporting high-risk, high-reward projects, J-WAFS has amplified the capacity of MIT faculty to pursue groundbreaking research that addresses some of the world’s most pressing challenges facing our water and food systems.

Drawing MIT faculty to water and food research

J-WAFS open calls for proposals enable faculty to explore bold ideas and develop impactful approaches to tackling critical water and food system challenges. Professor Patrick Doyle’s work in water purification exemplifies this impact. “Without J-WAFS, I would have never ventured into the field of water purification,” Doyle reflects. While previously focused on pharmaceutical manufacturing and drug delivery, exposure to J-WAFS-funded peers led him to apply his expertise in soft materials to water purification. “Both the funding and the J-WAFS community led me to be deeply engaged in understanding some of the key challenges in water purification and water security,” he explains.

Similarly, Professor Otto Cordero of the Department of Civil and Environmental Engineering (CEE) leveraged J-WAFS funding to pivot his research into aquaculture. Cordero explains that his first J-WAFS seed grant “has been extremely influential for my lab because it allowed me to take a step in a new direction, with no preliminary data in hand.” Cordero’s expertise is in microbial communities. He was previous unfamiliar with aquaculture, but he saw the relevance of microbial communities the health of farmed aquatic organisms.

Supporting early-career faculty

New assistant professors at MIT have particularly benefited from J-WAFS funding and support. J-WAFS has played a transformative role in shaping the careers and research trajectories of many new faculty members by encouraging them to explore novel research areas, and in many instances providing their first MIT research grant.

Professor Ariel Furst reflects on how pivotal J-WAFS’ investment has been in advancing her research. “This was one of the first grants I received after starting at MIT, and it has truly shaped the development of my group’s research program,” Furst explains. With J-WAFS’ backing, her lab has achieved breakthroughs in chemical detection and remediation technologies for water. “The support of J-WAFS has enabled us to develop the platform funded through this work beyond the initial applications to the general detection of environmental contaminants and degradation of those contaminants,” she elaborates. 

Karthish Manthiram, now a professor of chemical engineering and chemistry at Caltech, explains how J-WAFS’ early investment enabled him and other young faculty to pursue ambitious ideas. “J-WAFS took a big risk on us,” Manthiram reflects. His research on breaking the nitrogen triple bond to make ammonia for fertilizer was initially met with skepticism. However, J-WAFS’ seed funding allowed his lab to lay the groundwork for breakthroughs that later attracted significant National Science Foundation (NSF) support. “That early funding from J-WAFS has been pivotal to our long-term success,” he notes. 

These stories underscore the broad impact of J-WAFS’ support for early-career faculty, and its commitment to empowering them to address critical global challenges and innovate boldly.

Fueling follow-on funding 

J-WAFS seed grants enable faculty to explore nascent research areas, but external funding for continued work is usually necessary to achieve the full potential of these novel ideas. “It’s often hard to get funding for early stage or out-of-the-box ideas,” notes J-WAFS Director Professor John H. Lienhard V. “My hope, when I founded J-WAFS in 2014, was that seed grants would allow PIs [principal investigators] to prove out novel ideas so that they would be attractive for follow-on funding. And after 10 years, J-WAFS-funded research projects have brought more than $21 million in subsequent awards to MIT.”

Professor Retsef Levi led a seed study on how agricultural supply chains affect food safety, with a team of faculty spanning the MIT schools Engineering and Science as well as the MIT Sloan School of Management. The team parlayed their seed grant research into a multi-million-dollar follow-on initiative. Levi reflects, “The J-WAFS seed funding allowed us to establish the initial credibility of our team, which was key to our success in obtaining large funding from several other agencies.”

Dave Des Marais was an assistant professor in the Department of CEE when he received his first J-WAFS seed grant. The funding supported his research on how plant growth and physiology are controlled by genes and interact with the environment. The seed grant helped launch his lab’s work addressing enhancing climate change resilience in agricultural systems. The work led to his Faculty Early Career Development (CAREER) Award from the NSF, a prestigious honor for junior faculty members. Now an associate professor, Des Marais’ ongoing project to further investigate the mechanisms and consequences of genomic and environmental interactions is supported by the five-year, $1,490,000 NSF grant. “J-WAFS providing essential funding to get my new research underway,” comments Des Marais.

Stimulating interdisciplinary collaboration

Des Marais’ seed grant was also key to developing new collaborations. He explains, “the J-WAFS grant supported me to develop a collaboration with Professor Caroline Uhler in EECS/IDSS [the Department of Electrical Engineering and Computer Science/Institute for Data, Systems, and Society] that really shaped how I think about framing and testing hypotheses. One of the best things about J-WAFS is facilitating unexpected connections among MIT faculty with diverse yet complementary skill sets.”

Professors A. John Hart of the Department of Mechanical Engineering and Benedetto Marelli of CEE also launched a new interdisciplinary collaboration with J-WAFS funding. They partnered to join expertise in biomaterials, microfabrication, and manufacturing, to create printed silk-based colorimetric sensors that detect food spoilage. “The J-WAFS Seed Grant provided a unique opportunity for multidisciplinary collaboration,” Hart notes.

Professors Stephen Graves in the MIT Sloan School of Management and Bishwapriya Sanyal in the Department of Urban Studies and Planning (DUSP) partnered to pursue new research on agricultural supply chains. With field work in Senegal, their J-WAFS-supported project brought together international development specialists and operations management experts to study how small firms and government agencies influence access to and uptake of irrigation technology by poorer farmers. “We used J-WAFS to spur a collaboration that would have been improbable without this grant,” they explain. Being part of the J-WAFS community also introduced them to researchers in Professor Amos Winter’s lab in the Department of Mechanical Engineering working on irrigation technologies for low-resource settings. DUSP doctoral candidate Mark Brennan notes, “We got to share our understanding of how irrigation markets and irrigation supply chains work in developing economies, and then we got to contrast that with their understanding of how irrigation system models work.”

Timothy Swager, professor of chemistry, and Rohit Karnik, professor of mechanical engineering and J-WAFS associate director, collaborated on a sponsored research project supported by Xylem, Inc. through the J-WAFS Research Affiliate program. The cross-disciplinary research, which targeted the development of ultra-sensitive sensors for toxic PFAS chemicals, was conceived following a series of workshops hosted by J-WAFS. Swager and Karnik were two of the participants, and their involvement led to the collaborative proposal that Xylem funded. “J-WAFS funding allowed us to combine Swager lab’s expertise in sensing with my lab’s expertise in microfluidics to develop a cartridge for field-portable detection of PFAS,” says Karnik. “J-WAFS has enriched my research program in so many ways,” adds Swager, who is now working to commercialize the technology.

Driving global collaboration and impact

J-WAFS has also helped MIT faculty establish and advance international collaboration and impactful global research. By funding and supporting projects that connect MIT researchers with international partners, J-WAFS has not only advanced technological solutions, but also strengthened cross-cultural understanding and engagement.

Professor Matthew Shoulders leads the inaugural J-WAFS Grand Challenge project. In response to the first J-WAFS call for “Grand Challenge” proposals, Shoulders assembled an interdisciplinary team based at MIT to enhance and provide climate resilience to agriculture by improving the most inefficient aspect of photosynthesis, the notoriously-inefficient carbon dioxide-fixing plant enzyme RuBisCO. J-WAFS funded this high-risk/high-reward project following a competitive process that engaged external reviewers through a several rounds of iterative proposal development. The technical feedback to the team led them to researchers with complementary expertise from the Australian National University. “Our collaborative team of biochemists and synthetic biologists, computational biologists, and chemists is deeply integrated with plant biologists and field trial experts, yielding a robust feedback loop for enzyme engineering,” Shoulders says. “Together, this team will be able to make a concerted effort using the most modern, state-of-the-art techniques to engineer crop RuBisCO with an eye to helping make meaningful gains in securing a stable crop supply, hopefully with accompanying improvements in both food and water security.”

Professor Leon Glicksman and Research Engineer Eric Verploegen’s team designed a low-cost cooling chamber to preserve fruits and vegetables harvested by smallholder farmers with no access to cold chain storage. J-WAFS’ guidance motivated the team to prioritize practical considerations informed by local collaborators, ensuring market competitiveness. “As our new idea for a forced-air evaporative cooling chamber was taking shape, we continually checked that our solution was evolving in a direction that would be competitive in terms of cost, performance, and usability to existing commercial alternatives,” explains Verploegen, who is currently an MIT D-Lab affiliate. Following the team’s initial seed grant, the team secured a J-WAFS Solutions commercialization grant, which Verploegen say “further motivated us to establish partnerships with local organizations capable of commercializing the technology earlier in the project than we might have done otherwise.” The team has since shared an open-source design as part of its commercialization strategy to maximize accessibility and impact.

Bringing corporate sponsored research opportunities to MIT faculty

J-WAFS also plays a role in driving private partnerships, enabling collaborations that bridge industry and academia. Through its Research Affiliate Program, for example, J-WAFS provides opportunities for faculty to collaborate with industry on sponsored research, helping to convert scientific discoveries into licensable intellectual property (IP) that companies can turn into commercial products and services.

J-WAFS introduced professor of mechanical engineering Alex Slocum to a challenge presented by its research affiliate company, Xylem: how to design a more energy-efficient pump for fluctuating flows. With centrifugal pumps consuming an estimated 6 percent of U.S. electricity annually, Slocum and his then-graduate student Hilary Johnson SM '18, PhD '22 developed an innovative variable volute mechanism that reduces energy usage. “Xylem envisions this as the first in a new category of adaptive pump geometry,” comments Johnson. The research produced a pump prototype and related IP that Xylem is working on commercializing. Johnson notes that these outcomes “would not have been possible without J-WAFS support and facilitation of the Xylem industry partnership.” Slocum adds, “J-WAFS enabled Hilary to begin her work on pumps, and Xylem sponsored the research to bring her to this point … where she has an opportunity to do far more than the original project called for.”

Swager speaks highly of the impact of corporate research sponsorship through J-WAFS on his research and technology translation efforts. His PFAS project with Karnik described above was also supported by Xylem. “Xylem was an excellent sponsor of our research. Their engagement and feedback were instrumental in advancing our PFAS detection technology, now on the path to commercialization,” Swager says.

Looking forward

What J-WAFS has accomplished is more than a collection of research projects; a decade of impact demonstrates how J-WAFS’ approach has been transformative for many MIT faculty members. As Professor Mathias Kolle puts it, his engagement with J-WAFS “had a significant influence on how we think about our research and its broader impacts.” He adds that it “opened my eyes to the challenges in the field of water and food systems and the many different creative ideas that are explored by MIT.” 

This thriving ecosystem of innovation, collaboration, and academic growth around water and food research has not only helped faculty build interdisciplinary and international partnerships, but has also led to the commercialization of transformative technologies with real-world applications. C. Cem Taşan, the POSCO Associate Professor of Metallurgy who is leading a J-WAFS Solutions commercialization team that is about to launch a startup company, sums it up by noting, “Without J-WAFS, we wouldn’t be here at all.”  

As J-WAFS looks to the future, its continued commitment — supported by the generosity of its donors and partners — builds on a decade of success enabling MIT faculty to advance water and food research that addresses some of the world’s most pressing challenges.

Eight MIT researchers are among the 128 new members and 22 international members recently elected to the National Academy of Engineering (NAE) for 2025. Thirteen additional MIT alumni were also elected as new members.

One of the highest professional distinctions for engineers, membership in the NAE is given to individuals who have made outstanding contributions to “engineering research, practice, or education, including, where appropriate, significant contributions to the engineering literature” and to “the pioneering of new and developing fields of technology, making major advancements in traditional fields of engineering, or developing/implementing innovative approaches to engineering education.”

The eight MIT electees this year include:

Martin Zdenek Bazant, the E.G. Roos (1944) Chair Professor in the Department of Chemical Engineering, was honored for contributions to nonlinear electrochemical and electrokinetic phenomena, including induced charge electroosmosis, shock electrodialysis, capacitive desalination, and energy storage applications.

Moshe E. Ben-Akiva SM ’71, PhD ’73, the Edmund K. Turner Professor in the Department of Civil and Environmental Engineering, was honored for advances in transportation and infrastructure systems modeling and demand analysis. 

Charles L. Cooney SM ’67, PhD ’70, professor emeritus of the Department of Chemical Engineering, was honored for contributions to biochemical and pharmaceutical manufacturing that propelled the establishment and growth of the global biotechnology industry. 

Yoel Fink PhD ’00, a professor in the Department of Materials Science and Engineering and Department of Electrical Engineering and Computer Science (EECS), was honored for the design and production of structured photonic fibers, enabling surgeries and the invention of fabrics that sense and communicate. 

Tomás Lozano-Pérez ’73, SM ’77, PhD ’80, the School of Engineering Professor of Teaching Excellence in the Department of EECS and a principal investigator in the Computer Science and Artificial Intelligence Laboratory, was honored for contributions to robot motion planning and molecular design. 

Kristala L. Prather ’94, the Arthur Dehon Little Professor and head of the Department of Chemical Engineering, was honored for the development of innovative approaches to regulate metabolic flux in engineered microorganisms with applications to specialty chemicals production. 

Eric Swanson SM ’84, research affiliate at the Research Laboratory of Electronics and mentor for the MIT Deshpande Center for Technological Innovation, was honored for contributions and entrepreneurship in biomedical imaging and optical communications. 

Evelyn N. Wang ’00, MIT's vice president for climate and Ford Professor of Engineering in the Department of Mechanical Engineering, was honored for contributions to clean energy, water technology, and nanostructure-based phase change heat transfer, and for service to the nation.

“I am thrilled that eight MIT researchers, along with many others from our broader MIT community, have been elected to the National Academy of Engineering this year,” says Anantha P. Chandrakasan, dean of the School of Engineering, MIT’s chief innovation and strategy officer, and the Vannevar Bush Professor of Electrical Engineering and Computer Science. “This is a well-deserved recognition of their outstanding contributions to the field of engineering, and I extend my heartfelt congratulations to them all.”

Thirteen additional alumni were elected to the National Academy of Engineering this year. They are: Gregg T. Beckham SM ’04, PhD ’08; Douglas C. Cameron PhD ’87; Long-Qing Chen PhD ’90; Jennifer R. Cochran PhD ’01; Christopher Richard Doerr ’89, ’90, SM ’90, PhD ’95;  Justin Hanes PhD ’96; Elizabeth Ann Holm SM ’89; Denise C. Johnson SM ’97; Wayne R. Johnson ’68, SM ’68, ScD ’70; Concetta LaMarca '81; Maja J. Matarić SM ’90, PhD ’94; David V. Schaffer PhD ’98; and Lixia Zhang PhD ’89.

Cynthia Barnhart SM ’86, PhD ’88 will step down as MIT’s provost, effective July 1, President Sally Kornbluth announced today. Barnhart, who served as MIT’s chancellor for more than seven years before becoming provost in 2022, will return to the faculty following a sabbatical.

Barnhart led a variety of efforts to enhance academics and research at the Institute during her tenure as provost, which bridged a transition between two MIT presidents. She drew from deep-rooted experience in the MIT community, first as a graduate student and then as a faculty member for more than 30 years, serving in the Department of Civil and Environmental Engineering and in the MIT Sloan School of Management, with affiliations in the Operations Research Center and the Center for Transportation and Logistics.

Barnhart is only the second MIT administrator, following Julius Stratton, to serve as both chancellor and provost. She is also the first woman to serve in each of these roles.

“It has been a privilege to serve and to support our community’s efforts to lead in education, research, and impact in the world,” Barnhart says.

MIT’s provost is the Institute’s chief academic and budget officer, responsible for leading efforts to establish academic priorities, managing financial planning and research support, and overseeing MIT’s international engagements. The provost works closely with the president, school and college deans, vice provosts, executive vice president and treasurer (EVPT), faculty officers, and many other leaders to recruit and retain the best talent and then, as Barnhart puts it, “create the conditions for them to thrive and do their best work at MIT.”

“Cindy has been a wonderful partner in thinking and doing, and I will be forever grateful for having been able to tap her knowledge of the Institute’s people, culture, practices and institutional systems,” Kornbluth wrote in an email to the MIT community.

The next chapter

L. Rafael Reif named Barnhart provost as he was stepping down as MIT’s 17th president, citing her “values, skills, vision, and collaborative spirit.” Her appointment provided the Institute with continuity and helped to sustain momentum during the transition and the first years of Kornbluth’s presidency.

“A good provost is constantly solving problems over the widest range of scales, thinking at the level of systems and structures but also digging deep when needed. Cindy has brought discipline, commitment, and heart to this role, and it's been a privilege to work with her,” says Faculty Chair Mary Fuller.

As she proceeds with a long-planned sabbatical, Barnhart will focus on a project she has been working on as provost. The effort centers around creating a flexible, affordable educational experience and curriculum in order to dramatically increase the size of the nation’s science- and technology-based workforce.

Creating conditions for faculty to thrive

As chief budget officer, Barnhart worked closely with EVPT Glen Shor, Vice President for Finance Katie Hammer, and colleagues across the Institute to provide essential resources for the Institute’s education and research enterprises. She cites as points of pride implementing new central support for MIT’s under-recovery system, closing the NASA and U.S. National Science Foundation (NSF) fellowship tuition and stipend shortfalls, and expanding the number of Office of the Provost professorship chairs to 230, an increase of more than 20 percent.

“The review of the Institute’s budget process that we launched last year is critical to the Institute’s effective response to emerging financial constraints,” Barnhart says.

“It’s about providing our community with access to the tools needed to develop strategic, creative ways to deploy our resources so that, even in the face of budget challenges, we can help people do what they came here to do — discover, invent, innovate, and problem solve, all in service to the nation and the world,” she says.

Responding to calls for more faculty involvement in searches to identify faculty leaders in the Office of the Provost, Barnhart established best practices for search advisory committees. Over the course of her tenure, these faculty-led groups assisted with the appointments of Vice Provost for Faculty Paula Hammond, Vice Provost for Open Learning Dimitris Bertsimas, Vice Provost for International Activities Duane Boning, MIT Sloan School of Management Dean Rick Locke, and Interim CEO and Director of the Singapore-MIT Alliance for Research and Technology (SMART) Bruce Tidor. In addition, Barnhart convened a search committee to identify a new leader to steward MIT’s research enterprise, which informed President Kornbluth’s appointment of Vice President for Research Ian A. Waitz last year.

“MIT’s next provost is going to be working with an exceptional team,” says Barnhart. “The Provost’s Office is positioned to ensure the faculty have what they need to make big impacts in research and education.”

Barnhart took several steps to provide her leadership team and faculty more broadly with professional development and career advancement opportunities. She standardized appointment and reappointment terms, created 360-degree feedback mechanisms, and formalized reappointment review processes for deans and vice provosts. In partnership with Hammond, new programs were launched on establishing positive department climates, generating impactful research funding proposals, and fostering effective graduate student mentoring.

“Cindy has always cared greatly about the faculty experience, and this deep regard is evident in all that she has done,” Hammond says. “She has sought to understand how we might better build a supportive environment that fosters faculty success and has invested in meaningful programs and policies that help to address faculty needs while developing tools for faculty to accomplish their professional and leadership goals.”

Barnhart and Hammond also partnered with Fuller, the MIT Institutional Research team, and other colleagues to assess MIT’s progress on addressing the findings of two landmark reports: the 1999 Study on the Status of Women Faculty in Science at MIT and the 2010 Report on the Initiative for Faculty Race and Diversity.

Barnhart shared the group’s analysis and corresponding response plan with the entire faculty. In her message, Barnhart highlighted how “the original reports’ power sprang from the rigorous analysis the authors conducted and from how openly our community reflected on the problems they identified. For MIT to foster the diverse breadth of faculty excellence that is critical to our mission, we need that same collective embrace of data and transparency, dialogue and action again.”

Advancing 21st-century education and research

Barnhart is committed to making MIT’s education accessible and affordable to a much broader set of learners. With Bertsimas, Barnhart launched the next phase of MIT Open Learning, which involves ambitious plans to extend MIT’s commitment to providing global access to the Institute’s brand of education.

“With her good judgement, open mindedness, passion for quality education in the world, and love and deep knowledge of MIT, Cindy has been a great partner in reshaping the strategy for open learning,” Bertsimas says. “I look forward to continuing our partnership in the years to come.”

As computing has become increasingly integral to many disciplines, the creation of interdisciplinary computing courses through The Common Ground, degrees that blend computing with another field, and interdisciplinary computing faculty hires have expanded the forefront of MIT education and research. With Barnhart as a strong champion, the MIT Schwarzman College of Computing has been at the center of these efforts.

“Embracing the college’s efforts to broaden and deepen MIT’s world-leading strengths in interdisciplinary education and research is, simply put, in Barnhart’s DNA,” says Dan Huttenlocher, dean of the MIT Schwarzman College of Computing.

By design, the Institute’s strategic initiatives in climate, humanities, and life sciences also lean into this interdisciplinary approach. Barnhart worked alongside Kornbluth, Chief Innovation and Strategy Officer Anantha Chandrakasan, and many other faculty on the development of these efforts throughout her tenure.

“It has been a privilege working with Provost Barnhart and President Kornbluth to advance the Institute’s wide range of strategic initiatives,” says Chandrakasan. “With a sense of urgency that these initiatives demand, Provost Barnhart was instrumental in defining the vision for these missions, promoting broad engagement from the MIT community and beyond while paving critical pathways for seed funding and fundraising. It would have been impossible to launch these initiatives without her inspiring ideas, creative solutions, and incredible support.”

A systems thinker

After earning her PhD in transportation systems in 1988 at MIT, Barnhart joined the operations research faculty at the School of Industrial and Systems Engineering at Georgia Tech. She returned to MIT four years later in 1992 and has been at the Institute ever since. Her research, which she has continued throughout her time in leadership roles, focuses on the development of optimization models and methods for designing, planning, and operating transportation systems.

“I’m a systems thinker, an optimizer, and a problem solver,” Barnhart says. “That is one of the reasons I have enjoyed serving as provost, a role in which there certainly is no shortage of opportunity to apply my decision-making and problem-solving mindset.”

Barnhart became associate dean of the MIT School of Engineering in 2007 and served as acting dean in 2010-2011. As chancellor, she was responsible for “all things students” at MIT, including student life, undergraduate admissions, graduate student support, the first-year educational experience, and more. She also participated in strategic planning, faculty appointments, resource development, and campus planning as chancellor.

Barnhart has been an undergraduate adviser and has supervised graduate and undergraduate theses of students across the Institute, including in the departments of Civil and Environmental Engineering, Aeronautics and Astronautics, Mechanical Engineering, and Electrical Engineering and Computer Science; in the Engineering Systems Division; in the MIT Sloan School of Management; in the Operations Research Center; and in the Center for Transportation and Logistics. She has taught subjects jointly listed in these units on optimization and operations research, with applications to transportation operations, planning, and control.

Kornbluth will work with a group of faculty members drawn from each school and the college to help her in selecting the next provost. 

A new initiative will offer faculty in the MIT School of Humanities, Arts, and Social Sciences (SHASS) the opportunity to participate in a semester-long internal fellows program.

The SHASS Faculty Fellows program, administered by the MIT Human Insight Collaborative (MITHIC), will provide faculty with time to focus on their research, writing, or artistic production, and to receive collegial support for the same; to foster social and intellectual community within SHASS, including between faculty and students beyond the classroom; and provide informal opportunities to develop intergenerational professional mentorships.

“SHASS faculty have been eager for a supportive, vibrant internal community for the nearly 35 years I’ve been at MIT,” says Anne McCants, the Ann F. Friedlaender Professor of History, and Faculty Fellows Program committee chair. “By providing participants with UROPs [Undergraduate Research Opportunities Program projects] and other opportunities to interact with students, we’re demonstrating our commitment to fostering an environment in which faculty can recharge and sustain the high-quality teaching and service our community has come to expect and appreciate.”

The creation of the program was one of the recommendations included in a May 2024 SHASS Programming Initiative Report, an effort led by Keeril Makan, SHASS associate dean for strategic initiatives, and the Michael (1949) and Sonja Koerner Music Composition Professor.

The inaugural group of fellows for Spring 2026 includes:

• Héctor Beltrán, Class of 1957 Career Development Associate Professor, MIT Anthropology
• Volha Charnysh, Ford Career Development Associate Professor, Department of Political Science
• Kevin Dorst, assistant professor, MIT Philosophy
• Richard Nielsen, associate professor, Department of Political Science
• Emily Richmond Pollock, associate professor, MIT Music
• Jessica Ruffin, assistant professor, MIT Literature
• Robin Scheffler, associate professor, Program in Science, Technology, and Society

Tenure-line faculty are eligible to apply, with a maximum of 12 members selected per year, or roughly six participants per term.

Selected faculty will spend a semester outside the classroom while still holding time for sustained interaction with a small cohort of colleagues. Fellows can work with the dedicated students in UROP to advance their research projects while investing in a unique, cross-disciplinary set of conversations.

“I was honored to help design the Fellows Program and to serve on the review committee,” says Arthur Bahr, a professor in the Literature Section and a member of the Faculty Fellows Program Selection Committee. “I was fortunate to have wonderful mentors within Literature, but would have loved the opportunity to get to know and learn from colleagues in other fields, which the Fellows Program will offer.”

“What excites me about the Faculty Fellows Program — beyond the opportunity for faculty to connect with each other across disciplines and units — is that it will spotlight the excellence and centrality of the humanities, arts, and social sciences at MIT,” says Heather Paxson, SHASS associate dean for faculty, and the William R. Kenan, Jr. Professor of Anthropology. “I look forward to hearing about new ideas sparked, and new friendships made, through participation in the program.”

Organizers say the program signals that MIT takes its investment in the humanities, arts and social sciences as seriously as its peer institutions, most of which have internal fellows programs.

“Given the strong demand for something like this, getting the program up and running is an important signal to SHASS faculty that Dean [Agustín] Rayo hears their concerns and is committed to supporting this type of community development,” McCants notes.