For the first time, MIT chemists have synthesized a fungal compound known as verticillin A, which was discovered more than 50 years ago and has shown potential as an anticancer agent.

The compound has a complex structure that made it more difficult to synthesize than related compounds, even though it differed by only a couple of atoms.

“We have a much better appreciation for how those subtle structural changes can significantly increase the synthetic challenge,” says Mohammad Movassaghi, an MIT professor of chemistry. “Now we have the technology where we can not only access them for the first time, more than 50 years after they were isolated, but also we can make many designed variants, which can enable further detailed studies.”

In tests in human cancer cells, a derivative of verticillin A showed particular promise against a type of pediatric brain cancer called diffuse midline glioma. More tests will be needed to evaluate its potential for clinical use, the researchers say.

Movassaghi and Jun Qi, an associate professor of medicine at Dana-Farber Cancer Institute/Boston Children’s Cancer and Blood Disorders Center and Harvard Medical School, are the senior authors of the study, which appears today in the Journal of the American Chemical Society. Walker Knauss PhD ’24 is the lead author of the paper. Xiuqi Wang, a medicinal chemist and chemical biologist at Dana-Farber, and Mariella Filbin, research director in the Pediatric Neurology-Oncology Program at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, are also authors of the study.

A complex synthesis

Researchers first reported the isolation of verticillin A from fungi, which use it for protection against pathogens, in 1970. Verticillin A and related fungal compounds have drawn interest for their potential anticancer and antimicrobial activity, but their complexity has made them difficult to synthesize.

In 2009, Movassaghi’s lab reported the synthesis of (+)-11,11'-dideoxyverticillin A, a fungal compound similar to verticillin A. That molecule has 10 rings and eight stereogenic centers, or carbon atoms that have four different chemical groups attached to them. These groups have to be attached in a way that ensures they have the correct orientation, or stereochemistry, with respect to the rest of the molecule.

Once that synthesis was achieved, however, synthesis of verticillin A remained challenging, even though the only difference between verticillin A and (+)-11,11'-dideoxyverticillin A is the presence of two oxygen atoms.

“Those two oxygens greatly limit the window of opportunity that you have in terms of doing chemical transformations,” Movassaghi says. “It makes the compound so much more fragile, so much more sensitive, so that even though we had had years of methodological advances, the compound continued to pose a challenge for us.”

Both of the verticillin A compounds consist of two identical fragments that must be joined together to form a molecule called a dimer. To create (+)-11,11'-dideoxyverticillin A, the researchers had performed the dimerization reaction near the end of the synthesis, then added four critical carbon-sulfur bonds.

Yet when trying to synthesize verticillin A, the researchers found that waiting to add those carbon-sulfur bonds at the end did not result in the correct stereochemistry. As a result, the researchers had to rethink their approach and ended up creating a very different synthetic sequence.

“What we learned was the timing of the events is absolutely critical. We had to significantly change the order of the bond-forming events,” Movassaghi says.

The verticillin A synthesis begins with an amino acid derivative known as beta-hydroxytryptophan, and then step-by-step, the researchers add a variety of chemical functional groups, including alcohols, ketones, and amides, in a way that ensures the correct stereochemistry.

A functional group containing two carbon-sulfur bonds and a disulfide bond were introduced early on, to help control the stereochemistry of the molecule, but the sensitive disulfides had to be “masked” and protected as a pair of sulfides to prevent them from breakdown under subsequent chemical reactions. The disulfide-containing groups were then regenerated after the dimerization reaction.

“This particular dimerization really stands out in terms of the complexity of the substrates that we’re bringing together, which have such a dense array of functional groups and stereochemistry,” Movassaghi says.

The overall synthesis requires 16 steps from the beta-hydroxytryptophan starting material to verticillin A.

Killing cancer cells

Once the researchers had successfully completed the synthesis, they were also able to tweak it to generate derivates of verticillin A. Researchers at Dana-Farber then tested these compounds against several types of diffuse midline glioma (DMG), a rare brain tumor that has few treatment options.

The researchers found that the DMG cell lines most susceptible to these compounds were those that have high levels of a protein called EZHIP. This protein, which plays a role in the methylation of DNA, has been previously identified as a potential drug target for DMG.

“Identifying the potential targets of these compounds will play a critical role in further understanding their mechanism of action, and more importantly, will help optimize the compounds from the Movassaghi lab to be more target specific for novel therapy development,” Qi says.

The verticillin derivatives appear to interact with EZHIP in a way that increases DNA methylation, which induces the cancer cells to under programmed cell death. The compounds that were most successful at killing these cells were N-sulfonylated (+)-11,11'-dideoxyverticillin A and N-sulfonylated verticillin A. N-sulfonylation — the addition of a functional group containing sulfur and oxygen — makes the molecules more stable.

“The natural product itself is not the most potent, but it’s the natural product synthesis that brought us to a point where we can make these derivatives and study them,” Movassaghi says.

The Dana-Farber team is now working on further validating the mechanism of action of the verticillin derivatives, and they also hope to begin testing the compounds in animal models of pediatric brain cancers.

“Natural compounds have been valuable resources for drug discovery, and we will fully evaluate the therapeutic potential of these molecules by integrating our expertise in chemistry, chemical biology, cancer biology, and patient care. We have also profiled our lead molecules in more than 800 cancer cell lines, and will be able to understand their functions more broadly in other cancers,” Qi says.

The research was funded by the National Institute of General Medical Sciences, the Ependymoma Research Foundation, and the Curing Kids Cancer Foundation.

More than 600 undergraduate students crowded into the Stratton Student Center on Oct. 28, for MIT’s first-ever Institute-wide Undergraduate Research Opportunities Program (UROP) mixer.

“At MIT, we believe in the transformative power of learning by doing, and there’s no better example than UROP,” says MIT President Sally Kornbluth, who attended the mixer with Provost Anantha Chandrakasan and Chancellor Melissa Nobles. “The energy at the inaugural UROP mixer was exhilarating, and I’m delighted that students now have this easy way to explore different paths to the frontiers of research.”

The event gave students the chance to explore internships and undergraduate research opportunities — in fields ranging from artificial intelligence to the life sciences to the arts, and beyond — all in one place, with approximately 150 researchers from labs available to discuss the projects and answer questions in real time. The offices of the Chancellor and Provost co-hosted the event, which the UROP office helped coordinate. 

First-year student Isabell Luo recently began a UROP project in the Living Matter lab led by Professor Rafael Gómez-Bombarelli, where she is benchmarking machine-learned interatomic potentials that simulate chemical reactions at the molecular level and exploring fine-tuning strategies to improve their accuracy. She’s passionate about AI and machine learning, eco-friendly design, and entrepreneurship, and was attending the UROP mixer to find more “real-world” projects to work on.

“I’m trying to dip my toes into different areas, which is why I’m at the mixer,” said Luo. “On the internet it would be so hard to find the right opportunities. It’s nice to have a physical space and speak to people from so many disciplines.”

More than nine out of every 10 members of MIT’s class of 2025 took part in a UROP before graduating. In recent years, approximately 3,200 undergraduates have participated in a UROP project each year. To meet the strong demand for UROPs, the Institute will commit up to $1 million in funding this year to create more of them. The funding will come from MIT’s schools and Office of the Provost. 

“UROPs have become an indispensable part of the MIT undergraduate education, providing hands-on experience that really helps students learn new ways to problem-solve and innovate,” says Chandrakasan. “I was thrilled to see so many students at the mixer — it was a testament to their willingness to roll up their sleeves and get to work on really tough challenges.”

Arielle Berman, a postdoc in the Raman Lab, was looking to recruit an undergraduate researcher for a project on sensor integration for muscle actuators for biohybrid robots — robots that include living parts. She spoke about how her own research experience as an undergraduate had shaped her career.

“It’s a really important event because we’re able to expose undergraduates to research,” says Berman. “I’m the first PhD in my family, so I wasn’t aware that research existed, or could be a career. Working in a research lab as an undergraduate student changed my life trajectory, and I’m happy to pass it forward and help students have experiences they wouldn’t have otherwise.”

The event drew students with interests as varied as the projects available. For first-year Nate Black, who plans to major in mechanical engineering, “I just wanted something to develop my interest in 3D printing and additive manufacturing.” First-year Akpandu Ekezie, who expects to major in Course 6-5 (Electrical Engineering with Computing), was interested in photonic circuits. “I’m looking mainly for EE-related things that are more hands-on,” he explained. “I want to get more physical experience.”

Nobles has a message for students considering a UROP project: Just go for it. “There’s a UROP for every student, regardless of experience,” she says. “Find something that excites you and give it a try.” She encourages students who weren’t able to attend the mixer, as well as those who did attend but still have questions, to get in touch with the UROP office.

First-year students Ruby Mykkanen and Aditi Deshpande attended the mixer together. Both were searching for UROP projects they could work on during Independent Activities Period in January. Deshpande also noted that the mixer was helpful for understanding “what research is being done at MIT.”

Said Mykkanen, “It’s fun to have it all in one place!”

Imagine having a continuum soft robotic arm bend around a bunch of grapes or broccoli, adjusting its grip in real time as it lifts the object. Unlike traditional rigid robots that generally aim to avoid contact with the environment as much as possible and stay far away from humans for safety reasons, this arm senses subtle forces, stretching and flexing in ways that mimic more of the compliance of a human hand. Its every motion is calculated to avoid excessive force while achieving the task efficiently. In MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) and Laboratory for Information and Decisions Systems (LIDS) labs, these seemingly simple movements are the culmination of complex mathematics, careful engineering, and a vision for robots that can safely interact with humans and delicate objects.

Soft robots, with their deformable bodies, promise a future where machines move more seamlessly alongside people, assist in caregiving, or handle delicate items in industrial settings. Yet that very flexibility makes them difficult to control. Small bends or twists can produce unpredictable forces, raising the risk of damage or injury. This motivates the need for safe control strategies for soft robots. 

“Inspired by advances in safe control and formal methods for rigid robots, we aim to adapt these ideas to soft robotics — modeling their complex behavior and embracing, rather than avoiding, contact — to enable higher-performance designs (e.g., greater payload and precision) without sacrificing safety or embodied intelligence,” says lead senior author and MIT Assistant Professor Gioele Zardini, who is a principal investigator in LIDS and the Department of Civil and Environmental Engineering, and an affiliate faculty with the Institute for Data, Systems, and Society (IDSS). “This vision is shared by recent and parallel work from other groups.”

Safety first

The team developed a new framework that blends nonlinear control theory (controlling systems that involve highly complex dynamics) with advanced physical modeling techniques and efficient real-time optimization to produce what they call “contact-aware safety.” At the heart of the approach are high-order control barrier functions (HOCBFs) and high-order control Lyapunov functions (HOCLFs). HOCBFs define safe operating boundaries, ensuring the robot doesn’t exert unsafe forces. HOCLFs guide the robot efficiently toward its task objectives, balancing safety with performance.

“Essentially, we’re teaching the robot to know its own limits when interacting with the environment while still achieving its goals,” says MIT Department of Mechanical Engineering PhD student Kiwan Wong, the lead author of a new paper describing the framework. “The approach involves some complex derivation of soft robot dynamics, contact models, and control constraints, but the specification of control objectives and safety barriers is rather straightforward for the practitioner, and the outcomes are very tangible, as you see the robot moving smoothly, reacting to contact, and never causing unsafe situations.”

“Compared with traditional kinematic CBFs — where forward-invariant safe sets are hard to specify — the HOCBF framework simplifies barrier design, and its optimization formulation accounts for system dynamics (e.g., inertia), ensuring the soft robot stops early enough to avoid unsafe contact forces,” says Worcester Polytechnic Institute Assistant Professor and former CSAIL postdoc Wei Xiao.

“Since soft robots emerged, the field has highlighted their embodied intelligence and greater inherent safety relative to rigid robots, thanks to passive material and structural compliance. Yet their “cognitive” intelligence — especially safety systems — has lagged behind that of rigid serial-link manipulators,” says co-lead author Maximilian Stölzle, a research intern at Disney Research and formerly a Delft University of Technology PhD student and visiting researcher at MIT LIDS and CSAIL. “This work helps close that gap by adapting proven algorithms to soft robots and tailoring them for safe contact and soft-continuum dynamics.”

The LIDS and CSAIL team tested the system on a series of experiments designed to challenge the robot’s safety and adaptability. In one test, the arm pressed gently against a compliant surface, maintaining a precise force without overshooting. In another, it traced the contours of a curved object, adjusting its grip to avoid slippage. In yet another demonstration, the robot manipulated fragile items alongside a human operator, reacting in real time to unexpected nudges or shifts. “These experiments show that our framework is able to generalize to diverse tasks and objectives, and the robot can sense, adapt, and act in complex scenarios while always respecting clearly defined safety limits,” says Zardini.

Soft robots with contact-aware safety could be a real value-add in high-stakes places, of course. In health care, they could assist in surgeries, providing precise manipulation while reducing risk to patients. In industry, they might handle fragile goods without constant supervision. In domestic settings, robots could help with chores or caregiving tasks, interacting safely with children or the elderly — a key step toward making soft robots reliable partners in real-world environments. 

“Soft robots have incredible potential,” says co-lead senior author Daniela Rus, director of CSAIL and a professor in the Department of Electrical Engineering and Computer Science. “But ensuring safety and encoding motion tasks via relatively simple objectives has always been a central challenge. We wanted to create a system where the robot can remain flexible and responsive while mathematically guaranteeing it won’t exceed safe force limits.”

Combining soft robot models, differentiable simulation, and control theory

Underlying the control strategy is a differentiable implementation of something called the Piecewise Cosserat-Segment (PCS) dynamics model, which predicts how a soft robot deforms and where forces accumulate. This model allows the system to anticipate how the robot’s body will respond to actuation and complex interactions with the environment. “The aspect that I most like about this work is the blend of integration of new and old tools coming from different fields like advanced soft robot models, differentiable simulation, Lyapunov theory, convex optimization, and injury-severity–based safety constraints. All of this is nicely blended into a real-time controller fully grounded in first principles,” says co-author Cosimo Della Santina, who is an associate professor at Delft University of Technology. 

Complementing this is the Differentiable Conservative Separating Axis Theorem (DCSAT), which estimates distances between the soft robot and obstacles in the environment that can be approximated with a chain of convex polygons in a differentiable manner. “Earlier differentiable distance metrics for convex polygons either couldn’t compute penetration depth — essential for estimating contact forces — or yielded non-conservative estimates that could compromise safety,” says Wong. “Instead, the DCSAT metric returns strictly conservative, and therefore safe, estimates while simultaneously allowing for fast and differentiable computation.” Together, PCS and DCSAT give the robot a predictive sense of its environment for more proactive, safe interactions.

Looking ahead, the team plans to extend their methods to three-dimensional soft robots and explore integration with learning-based strategies. By combining contact-aware safety with adaptive learning, soft robots could handle even more complex, unpredictable environments. 

“This is what makes our work exciting,” says Rus. “You can see the robot behaving in a human-like, careful manner, but behind that grace is a rigorous control framework ensuring it never oversteps its bounds.”

“Soft robots are generally safer to interact with than rigid-bodied robots by design, due to the compliance and energy-absorbing properties of their bodies,” says University of Michigan Assistant Professor Daniel Bruder, who wasn’t involved in the research. “However, as soft robots become faster, stronger, and more capable, that may no longer be enough to ensure safety. This work takes a crucial step towards ensuring soft robots can operate safely by offering a method to limit contact forces across their entire bodies.”

The team’s work was supported, in part, by The Hong Kong Jockey Club Scholarships, the European Union’s Horizon Europe Program, Cultuurfonds Wetenschapsbeurzen, and the Rudge (1948) and Nancy Allen Chair. Their work was published earlier this month in the Institute of Electrical and Electronics Engineers’ Robotics and Automation Letters.

Researchers at MIT have demonstrated that wedge-shaped vortex generators attached to a ship’s hull can reduce drag by up to 7.5 percent, which reduces overall ship emissions and fuel expenses. The paper, “Net Drag Reduction in High Block Coefficient Ships and Vehicles Using Vortex Generators,” was presented at the Society of Naval Architects and Marine Engineers 2025 Maritime Convention in Norfolk, Virginia.

The work offers a promising path toward decarbonization, addressing the pressing need to meet the International Maritime Organization (IMO) goal to reduce carbon intensity of international shipping by at least 40 percent by 2030, compared to 2008 levels. Achieving such ambitious emissions reduction will require a coordinated approach, employing multiple methods, from redesigning ship hulls, propellers, and engines to using novel fuels and operational methods.

The researchers — José del Águila Ferrandis, Jack Kimmeth, and Michael Triantafyllou of MIT Sea Grant and the Department of Mechanical Engineering, along with Alfonso Parra Rubio and Neil Gershenfeld of the Center for Bits and Atoms — determined the optimized vortex generator shape and size using a combination of computational fluid dynamics (CFD) and experimental methods guided by AI optimization methods. 

The team first established parametric trends through extensive CFD analysis, and then tested multiple hulls through rapid prototyping to validate the results experimentally. Scale models of an axisymmetric hull with a bare tail, a tail with delta wing vortex generators, and a tail with wedge vortex generators were produced and tested. The team identified wedge-like vortex generators as the key shape that could achieve this level of drag reduction. 

Through flow visualization, the researchers could see that drag was reduced by delaying turbulent flow separation, helping water flow more smoothly along the ship’s hull, shrinking the wake behind the vessel. This also allows the propeller and rudder to work more efficiently in a uniform flow. “We document for the first time experimentally a reduction in fuel required by ships using vortex generators, relatively small structures in the shape of a wedge attached at a specific point of the ship’s hull,” explains Michael Triantafyllou, professor of mechanical engineering and director of MIT Sea Grant. 

Vortex generators have long been used in aircraft-wing design to maintain lift and delay stalling. This study is the first to show that the vortex generators can be applied for drag reduction in commercial ships.

The modular adaptability of the wedge vortex generators would allow integration into a broad range of hull forms, including bulk carriers and tankers, and the devices can synergize with, or even replace, existing technologies like pre-swirl stators (fixed fins mounted in front of propellers), improving overall system performance. As an example case, the researchers estimate that installing the vortex generators on a 300-meter Newcastlemax bulk carrier operating at 14.5 knots over a cross-Pacific route would result in significantly reduced emissions and approximately $750,000 in fuel savings per year.

The findings offer a practical, cost-effective solution that could be implemented efficiently across existing fleets. This study was supported through the CBA Consortium, working with Oldendorff Carriers, which operates about 700 bulk carriers around the world. An extension of this research is supported by the MIT Maritime Consortium, led by MIT professors Themis Sapsis and Fotini Christia. The Maritime Consortium was formed in 2025 to address critical gaps in the modernization of the commercial fleet through interdisciplinary research and collaboration across academia, industry, and regulatory agencies.

Norway is the world’s largest producer of farmed Atlantic salmon and a top exporter of seafood, while the United States remains the largest importer of these products, according to the Food and Agriculture Organization. Two MIT students recently traveled to Trondheim, Norway to explore the cutting-edge technologies being developed and deployed in offshore aquaculture. 

Beckett Devoe, a senior in artificial intelligence and decision-making, and Tony Tang, a junior in mechanical engineering, first worked with MIT Sea Grant through the Undergraduate Research Opportunities Program (UROP). They contributed to projects focusing on wave generator design and machine learning applications for analyzing oyster larvae health in hatcheries. While near-shore aquaculture is a well-established industry across Massachusetts and the United States, open-ocean farming is still a nascent field here, facing unique and complex challenges. 

To help better understand this emerging industry, MIT Sea Grant created a collaborative initiative, AquaCulture Shock, with funding from an Aquaculture Technologies and Education Travel Grant through the National Sea Grant College Program. Collaborating with the MIT-Scandinavia MISTI (MIT International Science and Technology Initiatives) program, MIT Sea Grant matched Devoe and Tang with aquaculture-related summer internships at SINTEF Ocean, one of the largest research institutes in Europe. 

“The opportunity to work on this hands-on aquaculture project, under a world-renowned research institution, in an area of the world known for its innovation in marine technology — this is what MISTI is all about,” says Madeline Smith, managing director for MIT-Scandinavia. “Not only are students gaining valuable experience in their fields of study, but they’re developing cultural understanding and skills that equip them to be future global leaders.” Both students worked within SINTEF Ocean’s Aquaculture Robotics and Autonomous Systems Laboratory (ACE-Robotic Lab), a facility designed to develop and test new aquaculture technologies. 

“Norway has this unique geography where it has all of these fjords,” says Sveinung Ohrem, research manager for the Aquaculture Robotics and Automation Group at SINTEF Ocean. “So you have a lot of sheltered waters, which makes it ideal to do sea-based aquaculture.” He estimates that there are about a thousand fish farms along Norway’s coast, and walks through some of the tools being used in the industry: decision-making systems to gather and visualize data for the farmers and operators; robots for inspection and cleaning; environmental sensors to measure oxygen, temperature, and currents; echosounders that send out acoustic signals to track where the fish are; and cameras to help estimate biomass and fine-tune feeding. “Feeding is a huge challenge,” he notes. “Feed is the largest cost, by far, so optimizing feeding leads to a very significant decrease in your cost.”

During the internship, Devoe focused on a project that uses AI for fish feeding optimization. “I try to look at the different features of the farm — so maybe how big the fish are, or how cold the water is ... and use that to try to give the farmers an optimal feeding amount for the best outcomes, while also saving money on feed,” he explains. “It was good to learn some more machine learning techniques and just get better at that on a real-world project.” 

In the same lab, Tang worked on the simulation of an underwater vehicle-manipulator system to navigate farms and repair damage on cage nets with a robotic arm. Ohrem says there are thousands of aquaculture robots operating in Norway today. “The scale is huge,” he says. “You can’t have 8,000 people controlling 8,000 robots — that’s not economically or practically feasible. So the level of autonomy in all of these robots needs to be increased.”

The collaboration between MIT and SINTEF Ocean began in 2023 when MIT Sea Grant hosted Eleni Kelasidi, a visiting research scientist from the ACE-Robotic Lab. Kelasidi collaborated with MIT Sea Grant director Michael Triantafyllou and professor of mechanical engineering Themistoklis Sapsis developing controllers, models, and underwater vehicles for aquaculture, while also investigating fish-machine interactions. 

“We have had a long and fruitful collaboration with the Norwegian University of Science and Technology (NTNU) and SINTEF, which continues with important efforts such as the aquaculture project with Dr. Kelasidi,” Triantafyllou says. “Norway is at the forefront of offshore aquaculture and MIT Sea Grant is investing in this field, so we anticipate great results from the collaboration.”

Kelasidi, who is now a professor at NTNU, also leads the Field Robotics Lab, focusing on developing resilient robotic systems to operate in very complex and harsh environments. “Aquaculture is one of the most challenging field domains we can demonstrate any autonomous solutions, because everything is moving,” she says. Kelasidi describes aquaculture as a deeply interdisciplinary field, requiring more students with backgrounds both in biology and technology. “We cannot develop technologies that are applied for industries where we don’t have biological components,” she explains, “and then apply them somewhere where we have a live fish or other live organisms.” 

Ohrem affirms that maintaining fish welfare is the primary driver for researchers and companies operating in aquaculture, especially as the industry continues to grow. “So the big question is,” he says, “how can you ensure that?” SINTEF Ocean has four research licenses for farming fish, which they operate through a collaboration with SalMar, the second-largest salmon farmer in the world. The students had the opportunity to visit one of the industrial-scale farms, Singsholmen, on the island of Hitra. The farm has 10 large, round net pens about 50 meters across that extend deep below the surface, each holding up to 200,000 salmon. “I got to physically touch the nets and see how the [robotic] arm might be able to fix the net,” says Tang. 

Kelasidi emphasizes that the information gained in the field cannot be learned from the office or lab. “That opens up and makes you realize, what is the scale of the challenges, or the scale of the facilities,” she says. She also highlights the importance of international and institutional collaboration to advance this field of research and develop more resilient robotic systems. “We need to try to target that problem, and let’s solve it together.”

MIT Sea Grant and the MIT-Scandinavia MISTI program are currently recruiting a new cohort of four MIT students to intern in Norway this summer with institutes advancing offshore farming technologies, including NTNU’s Field Robotics Lab in Trondheim. Students interested in autonomy, deep learning, simulation modeling, underwater robotic systems, and other aquaculture-related areas are encouraged to reach out to Lily Keyes at MIT Sea Grant.

Advancements in battery innovation are transforming both mobility and energy systems alike, according to Kurt Kelty, vice president of battery, propulsion, and sustainability at General Motors (GM). At the MIT Energy Initiative (MITEI) Fall Colloquium, Kelty explored how GM is bringing next-generation battery technologies from lab to commercialization, driving American battery innovation forward. The colloquium is part of the ongoing MITEI Presents: Advancing the Energy Transition speaker series.

At GM, Kelty’s team is primarily focused on three things: first, improving affordability to get more electric vehicles (EVs) on the road. “How do you drive down the cost?” Kelty asked the audience. “It's the batteries. The batteries make up about 30 percent of the cost of the vehicle.” Second, his team strives to improve battery performance, including charging speed and energy density. Third, they are working on localizing the supply chain. “We've got to build up our resilience and our independence here in North America, so we're not relying on materials coming from China,” Kelty explained.

To aid their efforts, resources are being poured into the virtualization space, significantly cutting down on time dedicated to research and development. Now, Kelty’s team can do modeling up front using artificial intelligence, reducing what previously would have taken months to a couple of days.

“If you want to modify … the nickel content ever so slightly, we can very quickly model: ‘OK, how’s that going to affect the energy density? The safety? How’s that going to affect the charge capability?’” said Kelty. “We can look at that at the cell level, then the pack level, then the vehicle level.”

Kelty revealed that they have found a solution that addresses affordability, accessibility, and commercialization: lithium manganese-rich (LMR) batteries. Previously, the industry looked to reduce costs by lowering the amount of cobalt in batteries by adding greater amounts of nickel. These high-nickel batteries are in most cars on the road in the United States due to their high range. LMR batteries, though, take things a step further by reducing the amount of nickel and adding more manganese, which drives the cost of batteries down even further while maintaining range.

Lithium-iron-phosphate (LFP) batteries are the chemistry of choice in China, known for low cost, high cycle life, and high safety. With LMR batteries, the cost is comparable to LFP with a range that is closer to high-nickel. “That’s what’s really a breakthrough,” said Kelty.

LMR batteries are not new, but there have been challenges to adopting them, according to Kelty. “People knew about it, but they didn’t know how to commercialize it. They didn’t know how to make it work in an EV,” he explained. Now that GM has figured out commercialization, they will be the first to market these batteries in their EVs in 2028.

Kelty also expressed excitement over the use of vehicle-to-grid technologies in the future. Using a bidirectional charger with a two-way flow of energy, EVs could charge, but also send power from their batteries back to the electrical grid. This would allow customers to charge “their vehicles at night when the electricity prices are really low, and they can discharge it during the day when electricity rates are really high,” he said.

In addition to working in the transportation sector, GM is exploring ways to extend their battery expertise into applications in grid-scale energy storage. “It’s a big market right now, but it’s growing very quickly because of the data center growth,” said Kelty.

When looking to the future of battery manufacturing and EVs in the United States, Kelty remains optimistic: “we’ve got the technology here to make it happen. We’ve always had the innovation here. Now, we’re getting more and more of the manufacturing. We’re getting that all together. We’ve got just tremendous opportunity here that I’m hopeful we’re going to be able to take advantage of and really build a massive battery industry here.”

This speaker series highlights energy experts and leaders at the forefront of the scientific, technological, and policy solutions needed to transform our energy systems. Visit MITEI’s Events page for more information on this and additional events.

“MIT hasn’t just prepared me for the future of work — it’s pushed me to study it. As AI systems become more capable, more of our online activity will be carried out by artificial agents. That raises big questions: How should we design these systems to understand our preferences? What happens when AI begins making many of our decisions?”

These are some of the questions MIT Sloan School of Management PhD candidate Benjamin Manning is researching. Part of his work investigates how to design and evaluate artificial intelligence agents that act on behalf of people, and how their behavior shapes markets and institutions. 

Previously, he received a master’s degree in public policy from the Harvard Kennedy School and a bachelor’s in mathematics from Washington University in St. Louis. After working as a research assistant, Manning knew he wanted to pursue an academic career.

“There’s no better place in the world to study economics and computer science than MIT,” he says. “Nobel and Turing award winners are everywhere, and the IT group lets me explore both fields freely. It was my top choice — when I was accepted, the decision was clear.” 

After receiving his PhD, Manning hopes to secure a faculty position at a business school and do the same type of work that MIT Sloan professors — his mentors — do every day.

“Even in my fourth year, it still feels surreal to be an MIT student. I don’t think that feeling will ever fade. My mom definitely won’t ever get over telling people about it.”

Of his MIT Sloan experience, Manning says he didn’t know it was possible to learn so much so quickly. “It’s no exaggeration to say I learned more in my first year as a PhD candidate than in all four years of undergrad. While the pace can be intense, wrestling with so many new ideas has been incredibly rewarding. It’s given me the tools to do novel research in economics and AI — something I never imagined I’d be capable of.”

As an economist studying AI simulations of humans, for Manning, the future of work not only means understanding how AI acts on our behalf, but also radically improving and accelerating social scientific discovery.

“Another part of my research agenda explores how well AI systems can simulate human responses. I envision a future where researchers test millions of behavioral simulations in minutes, rapidly prototyping experimental designs, and identifying promising research directions before investing in costly human studies. This isn’t about replacing human insight, but amplifying it: Scientists can focus on asking better questions, developing theory, and interpreting results while AI handles the computational heavy lifting.”

He’s excited by the prospect: “We are possibly moving toward a world where the pace of understanding may get much closer to the speed of economic change.”

Our muscles are nature’s actuators. The sinewy tissue is what generates the forces that make our bodies move. In recent years, engineers have used real muscle tissue to actuate “biohybrid robots” made from both living tissue and synthetic parts. By pairing lab-grown muscles with synthetic skeletons, researchers are engineering a menagerie of muscle-powered crawlers, walkers, swimmers, and grippers.

But for the most part, these designs are limited in the amount of motion and power they can produce. Now, MIT engineers are aiming to give bio-bots a power lift with artificial tendons.

In a study appearing today in the journal Advanced Science, the researchers developed artificial tendons made from tough and flexible hydrogel. They attached the rubber band-like tendons to either end of a small piece of lab-grown muscle, forming a “muscle-tendon unit.” Then they connected the ends of each artificial tendon to the fingers of a robotic gripper.

When they stimulated the central muscle to contract, the tendons pulled the gripper’s fingers together. The robot pinched its fingers together three times faster, and with 30 times greater force, compared with the same design without the connecting tendons.

The researchers envision the new muscle-tendon unit can be fit to a wide range of biohybrid robot designs, much like a universal engineering element.

“We are introducing artificial tendons as interchangeable connectors between muscle actuators and robotic skeletons,” says lead author Ritu Raman, an assistant professor of mechanical engineering (MechE) at MIT. “Such modularity could make it easier to design a wide range of robotic applications, from microscale surgical tools to adaptive, autonomous exploratory machines.”

The study’s MIT co-authors include graduate students Nicolas Castro, Maheera Bawa, Bastien Aymon, Sonika Kohli, and Angel Bu; undergraduate Annika Marschner; postdoc Ronald Heisser; alumni Sarah J. Wu ’19, SM ’21, PhD ’24 and Laura Rosado ’22, SM ’25; and MechE professors Martin Culpepper and Xuanhe Zhao.

Muscle’s gains

Raman and her colleagues at MIT are at the forefront of biohybrid robotics, a relatively new field that has emerged in the last decade. They focus on combining synthetic, structural robotic parts with living muscle tissue as natural actuators.

“Most actuators that engineers typically work with are really hard to make small,” Raman says. “Past a certain size, the basic physics doesn’t work. The nice thing about muscle is, each cell is an independent actuator that generates force and produces motion. So you could, in principle, make robots that are really small.”

Muscle actuators also come with other advantages, which Raman’s team has already demonstrated: The tissue can grow stronger as it works out, and can naturally heal when injured. For these reasons, Raman and others envision that muscly droids could one day be sent out to explore environments that are too remote or dangerous for humans. Such muscle-bound bots could build up their strength for unforeseen traverses or heal themselves when help is unavailable. Biohybrid bots could also serve as small, surgical assistants that perform delicate, microscale procedures inside the body.

All these future scenarios are motivating Raman and others to find ways to pair living muscles with synthetic skeletons. Designs to date have involved growing a band of muscle and attaching either end to a synthetic skeleton, similar to looping a rubber band around two posts. When the muscle is stimulated to contract, it can pull the parts of a skeleton together to generate a desired motion.

But Raman says this method produces a lot of wasted muscle that is used to attach the tissue to the skeleton rather than to make it move. And that connection isn’t always secure. Muscle is quite soft compared with skeletal structures, and the difference can cause muscle to tear or detach. What’s more, it is often only the contractions in the central part of the muscle that end up doing any work — an amount that’s relatively small and generates little force.

“We thought, how do we stop wasting muscle material, make it more modular so it can attach to anything, and make it work more efficiently?” Raman says. “The solution the body has come up with is to have tendons that are halfway in stiffness between muscle and bone, that allow you to bridge this mechanical mismatch between soft muscle and rigid skeleton. They’re like thin cables that wrap around joints efficiently.”

“Smartly connected”

In their new work, Raman and her colleagues designed artificial tendons to connect natural muscle tissue with a synthetic gripper skeleton. Their material of choice was hydrogel — a squishy yet sturdy polymer-based gel. Raman obtained hydrogel samples from her colleague and co-author Xuanhe Zhao, who has pioneered the development of hydrogels at MIT. Zhao’s group has derived recipes for hydrogels of varying toughness and stretch that can stick to many surfaces, including synthetic and biological materials.

To figure out how tough and stretchy artificial tendons should be in order to work in their gripper design, Raman’s team first modeled the design as a simple system of three types of springs, each representing the central muscle, the two connecting tendons, and the gripper skeleton. They assigned a certain stiffness to the muscle and skeleton, which were previously known, and used this to calculate the stiffness of the connecting tendons that would be required in order to move the gripper by a desired amount.

From this modeling, the team derived a recipe for hydrogel of a certain stiffness. Once the gel was made, the researchers carefully etched the gel into thin cables to form artificial tendons. They attached two tendons to either end of a small sample of muscle tissue, which they grew using lab-standard techniques. They then wrapped each tendon around a small post at the end of each finger of the robotic gripper — a skeleton design that was developed by MechE professor Martin Culpepper, an expert in designing and building precision machines.

When the team stimulated the muscle to contract, the tendons in turn pulled on the gripper to pinch its fingers together. Over multiple experiments, the researchers found that the muscle-tendon gripper worked three times faster and produced 30 times more force compared to when the gripper is actuated just with a band of muscle tissue (and without any artificial tendons). The new tendon-based design also was able to keep up this performance over 7,000 cycles, or muscle contractions.

Overall, Raman saw that the addition of artificial tendons increased the robot’s power-to-weight ratio by 11 times, meaning that the system required far less muscle to do just as much work.

“You just need a small piece of actuator that’s smartly connected to the skeleton,” Raman says. “Normally, if a muscle is really soft and attached to something with high resistance, it will just tear itself before moving anything. But if you attach it to something like a tendon that can resist tearing, it can really transmit its force through the tendon, and it can move a skeleton that it wouldn’t have been able to move otherwise.”

The team’s new muscle-tendon design successfully merges biology with robotics, says biomedical engineer Simone Schürle-Finke, associate professor of health sciences and technology at ETH Zürich.

“The tough-hydrogel tendons create a more physiological muscle–tendon–bone architecture, which greatly improves force transmission, durability, and modularity,” says Schürle-Finke, who was not involved with the study. “This moves the field toward biohybrid systems that can operate repeatably and eventually function outside the lab.”

With the new artificial tendons in place, Raman’s group is moving forward to develop other elements, such as skin-like protective casings, to enable muscle-powered robots in practical, real-world settings.

This research was supported, in part, by the U.S. Department of Defense Army Research Office, the MIT Research Support Committee, and the National Science Foundation.